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Selective Androgen Receptor Modulator (SARM) Treatment Prevents Bone Loss and Reduces Body Fat in Ovariectomized Rats
Mostly about BMD, but it covers effects on muscles, LH, LFH, talks about DHT, and there are a ton of links.
this is chalk full of DATA about s4
Results
We found that S-4 treatment maintained whole body and trabecular BMD, cortical content, and increased bone strength while decreasing body fat in these animals.
Conclusions
The data presented herein show the protective skeletal effects of S-4. Our previous reports have shown the tissue selectivity and muscle anabolic activity of S-4. Together these data suggest that S-4 could reduce the incidence of fracture via two different mechanisms (i.e., via direct effects in bone and reducing the incidence of falls through increased muscle strength). This approach to fracture reduction would be advantageous over current therapies in these patients which are primarily antiresorptive in nature.
also, very interesting when thinking about S4's affect on injuries:
DEXA, pQCT, and biomechanical strength testing on excised bones further validated the whole body DEXA results and support our hypothesis that SARMs inhibit bone loss. The L5–L6 BMD and the distal femur trabecular BMD data suggest that S-4 is a modest inhibitor of trabecular bone loss. We showed that the 0.5, 1.0, and 3.0 mg/day doses of S-4 were able to significantly increase BMD in the L5–L6 region and both 1.0 and 3.0 mg/day dose groups exhibited higher BMD in the distal femur.
DHT and S-4 significantly increased the maximum load required to break the femur compared to OVX controls. Further, S-4-treated groups showed a non-significant increase over DHT-treated controls. The effects of S-4 treatment on cortical bone were similar to those reported by Hanada et al. (26) during their evaluation of the anabolic effects of S-40503, in a rat model of osteoporosis. They concluded that S-40503 was anabolic in cortical bone (30 mg/kg dose).
S-4 is more potent than S-40503 in bone and levator ani muscle and more tissue selective (i.e., S-4 fully restored levator ani muscle weight at a dose that only restored the prostate to 34% of intact
Mostly about BMD, but it covers effects on muscles, LH, LFH, talks about DHT, and there are a ton of links.
this is chalk full of DATA about s4
Results
We found that S-4 treatment maintained whole body and trabecular BMD, cortical content, and increased bone strength while decreasing body fat in these animals.
Conclusions
The data presented herein show the protective skeletal effects of S-4. Our previous reports have shown the tissue selectivity and muscle anabolic activity of S-4. Together these data suggest that S-4 could reduce the incidence of fracture via two different mechanisms (i.e., via direct effects in bone and reducing the incidence of falls through increased muscle strength). This approach to fracture reduction would be advantageous over current therapies in these patients which are primarily antiresorptive in nature.
also, very interesting when thinking about S4's affect on injuries:
DEXA, pQCT, and biomechanical strength testing on excised bones further validated the whole body DEXA results and support our hypothesis that SARMs inhibit bone loss. The L5–L6 BMD and the distal femur trabecular BMD data suggest that S-4 is a modest inhibitor of trabecular bone loss. We showed that the 0.5, 1.0, and 3.0 mg/day doses of S-4 were able to significantly increase BMD in the L5–L6 region and both 1.0 and 3.0 mg/day dose groups exhibited higher BMD in the distal femur.
DHT and S-4 significantly increased the maximum load required to break the femur compared to OVX controls. Further, S-4-treated groups showed a non-significant increase over DHT-treated controls. The effects of S-4 treatment on cortical bone were similar to those reported by Hanada et al. (26) during their evaluation of the anabolic effects of S-40503, in a rat model of osteoporosis. They concluded that S-40503 was anabolic in cortical bone (30 mg/kg dose).
S-4 is more potent than S-40503 in bone and levator ani muscle and more tissue selective (i.e., S-4 fully restored levator ani muscle weight at a dose that only restored the prostate to 34% of intact
