when on steroids e.g sus 250 and deca does your sperm count go to 0,because i had a test b4 takin roids and my count was 6 million which the docter saud was ok butg would like to see it a bit beter well i had started on the juice so i woz like shit!! I put my sample in at the end of my 3 week post cycle therapy (pct) of clomid and it came back at 1 million which isnt good enough 2 get my bird pregnant so obviously they new i had been on roid could some one help and tell me when my sperm will be back 2 normal i finished my post cycle therapy (pct) last week
seaman count
- Thread starter Galla
- Start date
jarbulldog
bulldog god
I love to know the answer to this as well
could i take proviron a week after finishin post cycle therapy (pct) i took clomid for 3 weeks could i start takng clomid again would that help to build my sperm up
E
estray
Guest
Take some HCG.
even a week after finishing my post cycle therapy (pct) iz that ok?
E
estray
Guest
Oh, I missed that. In that case i wouldnt. Proviron would probably be a better choice like Trev said.
bluefawnpitbull
bluefawnpitbull
All my friends having kids...most former or current juicers. This is what I tell them, well, the smarter ones:
Leydig cells in the testis produce testosterone, sertoli cells produce sperm. Leydig cells respond to LH which is what HCG will mimick-the "beta subunit" of the HCG molecule fits into the LH receptor and the body does not know the difference. Correcting the LH with HCG is the first step.
If you are really serious about having a kid, you got to get intratestiticular testosterone up through elevating LH. The easiest way to do this is with a good 500-1000iu dose of Human Chorionic Gonadotropin (HCG), and for this purpose, you may need more. The reason is that the LH stimulates the leydig cells to secrete testosterone and the sertoli cells that produce sperm need a high intratesticular (within the testis) level of testosterone to produce sperm at their most efficient rate. In Sportsmedicine we say the sertoli cells need to be "bathed in a good concentration of testosterone".
LH comes from the pituitary and this Hpothalamic-Pituitary-Testicular Axis (HPTA) that you hear about is "refracted". You have temporary negative feedback to your pituitary from the sauce which shuts off the LH signal. When this happens (usually begins 2 weeks after even a low dose injection of AAS), the leydig cells begin to shrink from lack of stimulation. And if all you used was a little clomid, you may have increased your natural LH some, but not enough.
If you have noticeable shrinkage, this is more significant than the length of your recent cycle. The leydig cells make up for a good portion of testicular mass. So, if your nuts are shrunken, your leydig cells are shot.
Noticeable shrinkage or not, the best way to fix the issue is to take Human Chorionic Gonadotropin (HCG), but stay on your clomid until your "bird" gets pregnant. The clomid will aid recovery of the HPTA (which will slowly repair the FSH and LH), the HCG will immediately stimulate the leydig cells, and you will elevate the local/intratesticular testosterone to a greater extent so that your sertoli cells can more quickly begin producing their pre-cycle volume of sperm.
Good luck and God Bless.
P.S. as far as the proviron, the only thing it will do is aid your sex drive to do the "baby making". It is an androgenic component substite for the male. It has a good chance at aiding erection (clinical side effects include priapasm-prolonged erection), but if you have no problems in that department, you have no clinical use for proviron at the moment as far as fertility is concerned.
Now, that is the medical side talking, proviron will will not interfere regimen described above. It is just not going to do the trick by itself. It may actually help because the gun will be loaded, and may very well increase your desire to use it. Plus, it is a DHT derivative which acts as an anti-estrogen and can keep the physique a little harder and drier. Technically, anything that lowers estrogen in the male body has a shot at increasing testosterone by removing the negative feedback on the pituitary. Its just that pro-v is not used for this purpose, clinically clomid or nolvadex is much more proven for this purpose.
Leydig cells in the testis produce testosterone, sertoli cells produce sperm. Leydig cells respond to LH which is what HCG will mimick-the "beta subunit" of the HCG molecule fits into the LH receptor and the body does not know the difference. Correcting the LH with HCG is the first step.
If you are really serious about having a kid, you got to get intratestiticular testosterone up through elevating LH. The easiest way to do this is with a good 500-1000iu dose of Human Chorionic Gonadotropin (HCG), and for this purpose, you may need more. The reason is that the LH stimulates the leydig cells to secrete testosterone and the sertoli cells that produce sperm need a high intratesticular (within the testis) level of testosterone to produce sperm at their most efficient rate. In Sportsmedicine we say the sertoli cells need to be "bathed in a good concentration of testosterone".
LH comes from the pituitary and this Hpothalamic-Pituitary-Testicular Axis (HPTA) that you hear about is "refracted". You have temporary negative feedback to your pituitary from the sauce which shuts off the LH signal. When this happens (usually begins 2 weeks after even a low dose injection of AAS), the leydig cells begin to shrink from lack of stimulation. And if all you used was a little clomid, you may have increased your natural LH some, but not enough.
If you have noticeable shrinkage, this is more significant than the length of your recent cycle. The leydig cells make up for a good portion of testicular mass. So, if your nuts are shrunken, your leydig cells are shot.
Noticeable shrinkage or not, the best way to fix the issue is to take Human Chorionic Gonadotropin (HCG), but stay on your clomid until your "bird" gets pregnant. The clomid will aid recovery of the HPTA (which will slowly repair the FSH and LH), the HCG will immediately stimulate the leydig cells, and you will elevate the local/intratesticular testosterone to a greater extent so that your sertoli cells can more quickly begin producing their pre-cycle volume of sperm.
Good luck and God Bless.
P.S. as far as the proviron, the only thing it will do is aid your sex drive to do the "baby making". It is an androgenic component substite for the male. It has a good chance at aiding erection (clinical side effects include priapasm-prolonged erection), but if you have no problems in that department, you have no clinical use for proviron at the moment as far as fertility is concerned.
Now, that is the medical side talking, proviron will will not interfere regimen described above. It is just not going to do the trick by itself. It may actually help because the gun will be loaded, and may very well increase your desire to use it. Plus, it is a DHT derivative which acts as an anti-estrogen and can keep the physique a little harder and drier. Technically, anything that lowers estrogen in the male body has a shot at increasing testosterone by removing the negative feedback on the pituitary. Its just that pro-v is not used for this purpose, clinically clomid or nolvadex is much more proven for this purpose.
Thanx for that good info mate,so u think the best thing to do is start on the clomid again and hav a shot of hcg even a week after my pct??
bluefawnpitbull
bluefawnpitbull
Yes, absolutely, if you are truly serious about being fertile. Do you have concern about throwing off your post cycle therapy (pct)? If anything, your test level is probably not recovered and a few good rounds of HCG with clomid will help.
The goal with post cycle therapy (pct) is always to normalize testosterone physiology and production as much as possible to the state that it was in...before the cycle. Part of that physiology, is, the pre-cycle production of sperm.
Also, an "on label use" of HCG and clomid is to aid fertility in the male. I wasn't making things up. The mechanisms explained in the last post are physiologically based. If your sperm is that low, and you do not use recovery drugs to hasten the production, you may wait a long time to conceive. The HPTA recovers very slowly on its own or if it is left in a state of incomplete stimulation (not enough jump start from your post cycle therapy (pct) regimen).
It all depends on how serious of a goal that is (conception), I guess.
There are other recovery drugs like hMG that you can use for fertility if HCG and clomid do not work. But I really do believe that you just need to raise your natural testosterone and gonadotropins (LH, FSH).
The goal with post cycle therapy (pct) is always to normalize testosterone physiology and production as much as possible to the state that it was in...before the cycle. Part of that physiology, is, the pre-cycle production of sperm.
Also, an "on label use" of HCG and clomid is to aid fertility in the male. I wasn't making things up. The mechanisms explained in the last post are physiologically based. If your sperm is that low, and you do not use recovery drugs to hasten the production, you may wait a long time to conceive. The HPTA recovers very slowly on its own or if it is left in a state of incomplete stimulation (not enough jump start from your post cycle therapy (pct) regimen).
It all depends on how serious of a goal that is (conception), I guess.
There are other recovery drugs like hMG that you can use for fertility if HCG and clomid do not work. But I really do believe that you just need to raise your natural testosterone and gonadotropins (LH, FSH).
bluefawnpitbull
bluefawnpitbull
Agreed Trevdog, here is what I found when searching relevance on Pubmed.
Interesting. Summary is that Proviron is minimally effective for increasing LH and FSH, and thus minimum for sperm production increase. Some of these studies are pretty old, but, then again, so is Pro-v.
One thing I am psyched about is that Pro-V can be taken with gonadotropins. I was under the impression that due to its exclusive and high androgenic nature as a DHT derivative, it would result in negative feedback on the pituitary (despite the anti-estrogenic and aromatase binding effect it has).
I love this drug and have always used low dose with gonadotropins for HPTA recovery. I always thought on paper it made recovery less effecitve but kept my sex drive up and kept two types of muscles HARD during the recovery phase when systemic androgens are low. Plus this drug has been a valuable adjunct when shredding for me back in competing days. Check out these abstracts and thank you for pointing out looking further into the sperm production function. I'm sure this info can help many of us during post cycle therapy (pct) to keep sex drive up, lower muscle function 'active' without interfering with the recovery drugs we are taking.
1: Int J Gynaecol Obstet. 1988 Feb;26(1):121-8.
The effect of mesterolone on sperm count, on serum follicle stimulating hormone,
luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic
men.
Varma TR, Patel RH.
Department of Obstetrics & Gynaecology, St. George's Hospital Medical School
London, U.K.
Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20
million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal
analysis were assayed 3 times and serum follicle stimulating hormone (FSH)
luteinizing hormone (LH) and plasma testosterone were assayed once before
treatment and repeated at 3, 6, 9 and 12 months after the initiation of
treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma
testosterone, 85 patients (34%) had low serum FSH, LH and low plasma
testosterone. One hundred seventy-five patients (70%) had moderate oligospermia
(count 5 to less than 20 million/ml) and 75 patients (30%) had severe
oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic
patients showed significant improvement in the sperm density, total sperm count
and motility following mesterolone therapy whereas only 12% showed improvement in
the severe oligospermic group. Mesterolone had no depressing effect on low or
normal serum FSH and LH levels but had depressing effect on 25% if the levels
were elevated. There was no significant adverse effect on testosterone levels or
on liver function. One hundred fifteen (46%) pregnancies resulted following the
treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy.
Mesterolone was found to be more useful in patients with a sperm count ranging
between 5 and 20 million/ml. Those with severe oligospermia (count less than 5
million) do not seem to benefit from this therapy.
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Female
Follicle Stimulating Hormone/blood*
Humans
Luteinizing Hormone/blood*
Male
Mesterolone/pharmacology*
Middle Aged
Oligospermia/blood
Oligospermia/drug therapy*
Pregnancy
Semen/drug effects
Sperm Count/drug effects*
Sperm Motility/drug effects
Testosterone/blood*
Time Factors
Substances:
Mesterolone
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 2892728 [PubMed - indexed for MEDLINE]
2: Clin Endocrinol (Oxf). 1977 May;6(5):339-45.
The hormone response to a synthetic androgen (mesterolone) in oligospermia.
Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD.
Forty subfertile men with oligospermia were treated with a synthetic androgen
(Mesterolone). The effect of the drug was evaluated by measuring serum
testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and
analysing the semen before and after treatment. The results demonstrated that in
twenty-three patients treated for 6-9 months there was a significant decrease in
serum testosterone (P less than 0.01); the means +/- SEM before and after
treatment were 17.05 +/- 0.95 and 14.7 +/- 0.95 (nmol/l serum) respectively.
There was a pronounced increase in serum LH (P less than 0.01), the values being
2.73 +/- 0.26 and 3.61 +/- 0.3 (u/l) respectively. However, no significant
difference was found in serum FSH before and after treatment. The sperm
concentration showed a variable response to treatment. In twenty-one patients
there was either no change or worsening in the sperm concentration, whereas in
nineteen patients an improvement was observed. The analysis of variance of sperm
concentration and motility for the periods before and after treatment, for all
the patients, showed no significant difference in the sperm concentration F1.145
= 2.82 (P=0.1).
Mesh Terms:
Dihydrotestosterone/analogs & derivatives*
Follicle Stimulating Hormone/blood
Humans
Luteinizing Hormone/blood
Male
Mesterolone/therapeutic use*
Oligospermia/blood
Oligospermia/drug therapy*
Semen/drug effects
Testosterone/blood
Substances:
Mesterolone
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 872444 [PubMed - indexed for MEDLINE]
3: Int J Fertil. 1987 Jul-Aug;32(4):306-8.
The effects of mesterolone on sperm count in idiopathic oligospermia.
Bhathena RK, Jassawalla MJ, Patel DN.
Forty subfertile men with idiopathic oligospermia were randomly treated with
mesterolone or with placebo for more than 4 months. Seminal analysis was
performed thrice before treatment, and twice after 16 weeks of treatment. There
was a significant increase of semen volume (P less than .05), mean sperm
concentration (P less than .01), and mean total sperm count per ejaculate (P less
than .01) with mesterolone therapy. Sperm motility and morphological
characteristics were not modified by mesterolone therapy. Mesterolone was found
to be effective in improving the sperm concentration in mild and moderate rather
than in severe idiopathic oligospermia.
Publication Types:
Clinical Trial
Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Humans
Male
Mesterolone/therapeutic use*
Oligospermia/drug therapy*
Random Allocation
Semen/analysis
Sperm Count/drug effects*
Time Factors
Substances:
Mesterolone
Dihydrotestosterone
PMID: 2887529 [PubMed - indexed for MEDLINE]
4: Fertil Steril. 1991 Mar;55(3):603-7.
Placebo-controlled trial of high-dose Mesterolone treatment of idiopathic male
infertility.
Gerris J, Comhaire F, Hellemans P, Peeters K, Schoonjans F.
Department of Obstetrics and Gynecology, Middleheim General Hospital, Antwerp,
Belgium.
The possible effect of Mesterolone (Schering N.V., Brussels, Belgium) (1
alpha-methyl-5-alpha-androstane-17 beta-ol-3-one) on semen quality and fertility
of men with idiopathic oligoasthenospermia and/or teratozoospermia has been
evaluated in a double-blind trial. The study included 52 patients who were
treated during 12 months with either 150 mg/d of Mesterolone or placebo. The
overall pregnancy rate was similar in the Mesterolone-treated cases (26%) and in
the placebo control cases (48%), although a significant increase in motility and
in the proportion of spermatozoa with normal morphology was recorded in the
Mesterolone-treated cases. Because similar semen improvement also occurred in the
placebo controls, our findings cast doubt on the possible usefulness of high-dose
Mesterolone treatment of idiopathic male infertility.
Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Mesh Terms:
Administration, Oral
Dihydrotestosterone/blood
Double-Blind Method
Estradiol/blood
Follicle Stimulating Hormone/blood
Humans
Infertility, Male/drug therapy*
Luteinizing Hormone/blood
Male
Mesterolone/pharmacology*
Semen/drug effects
Sperm Count/drug effects
Sperm Motility/drug effects
Testosterone/blood
Time Factors
Substances:
Mesterolone
Estradiol
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 1900485 [PubMed - indexed for MEDLINE]
5: Eur Urol. 1977;3(5):292-4.
Combined mesterolon-clomiphene citrate therapy for treatment of oligospermia.
Bandhauer K, Meili HU.
42 subfertile patients with normal levels of plasma testerone (26 subnormal,
suffering from oligospermia) have been treated with a combination of clomiphene
citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period
of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a
significant improvement of the sperm count in 16. In 7, however, whilst the sperm
count improved the qualitative results were unsatisfactory as many sperms were
immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be
considered unfavourable but does not constitute a counter-indication to the
combined therapy. No hazardous complications were observed.
Mesh Terms:
Cell Count
Clomiphene/administration & dosage*
Clomiphene/therapeutic use
Dihydrotestosterone/analogs & derivatives*
Drug Therapy, Combination
Female
Follicle Stimulating Hormone/blood
Humans
Luteinizing Hormone/blood
Male
Mesterolone/administration & dosage*
Mesterolone/therapeutic use
Oligospermia/blood
Oligospermia/drug therapy*
Pregnancy
Spermatogenesis
Spermatozoa
Substances:
Mesterolone
Dihydrotestosterone
Luteinizing Hormone
Follicle Stimulating Hormone
Clomiphene
PMID: 913461 [PubMed - indexed for MEDLINE]
6: Int Urol Nephrol. 1978;10(3):251-6.
Mesterolone treatment of patients with pathospermia.
Szöllösi J, Falkay GY, Sas M.
The response to Mesterolone, in doses of 25 mg/day, was examined in 42
pathospermic patients. Treatment lasted for 100 days. The pronounced response to
the Mesterolone treatment was observed in hypozoo- and oligozoospermia with low
initial fructose content in the ejaculate. Fructose content attained its normal
range after the treatment. During the therapeutic period 11 wives became
pregnant. The authors conclude that Mesterolone does not influence plasma FSH, LH
and testosterone levels, it has only peripheral effects.
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Follicle Stimulating Hormone/blood
Fructose/analysis
Humans
Luteinizing Hormone/blood
Male
Mesterolone/administration & dosage
Mesterolone/therapeutic use*
Oligospermia/drug therapy*
Spermatozoa/analysis
Testosterone/blood
Substances:
Mesterolone
Fructose
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 689818 [PubMed - indexed for MEDLINE]
Interesting. Summary is that Proviron is minimally effective for increasing LH and FSH, and thus minimum for sperm production increase. Some of these studies are pretty old, but, then again, so is Pro-v.
One thing I am psyched about is that Pro-V can be taken with gonadotropins. I was under the impression that due to its exclusive and high androgenic nature as a DHT derivative, it would result in negative feedback on the pituitary (despite the anti-estrogenic and aromatase binding effect it has).
I love this drug and have always used low dose with gonadotropins for HPTA recovery. I always thought on paper it made recovery less effecitve but kept my sex drive up and kept two types of muscles HARD during the recovery phase when systemic androgens are low. Plus this drug has been a valuable adjunct when shredding for me back in competing days. Check out these abstracts and thank you for pointing out looking further into the sperm production function. I'm sure this info can help many of us during post cycle therapy (pct) to keep sex drive up, lower muscle function 'active' without interfering with the recovery drugs we are taking.
1: Int J Gynaecol Obstet. 1988 Feb;26(1):121-8.
The effect of mesterolone on sperm count, on serum follicle stimulating hormone,
luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic
men.
Varma TR, Patel RH.
Department of Obstetrics & Gynaecology, St. George's Hospital Medical School
London, U.K.
Two hundred fifty subfertile men with idiopathic oligospermia (count less than 20
million/ml) were treated with mesterolone (100-150 mg/day) for 12 months. Seminal
analysis were assayed 3 times and serum follicle stimulating hormone (FSH)
luteinizing hormone (LH) and plasma testosterone were assayed once before
treatment and repeated at 3, 6, 9 and 12 months after the initiation of
treatment. One hundred ten patients (44%) had normal serum FSH, LH and plasma
testosterone, 85 patients (34%) had low serum FSH, LH and low plasma
testosterone. One hundred seventy-five patients (70%) had moderate oligospermia
(count 5 to less than 20 million/ml) and 75 patients (30%) had severe
oligospermia (count less than 5 million/ml). Seventy-five moderately oligospermic
patients showed significant improvement in the sperm density, total sperm count
and motility following mesterolone therapy whereas only 12% showed improvement in
the severe oligospermic group. Mesterolone had no depressing effect on low or
normal serum FSH and LH levels but had depressing effect on 25% if the levels
were elevated. There was no significant adverse effect on testosterone levels or
on liver function. One hundred fifteen (46%) pregnancies resulted following the
treatment, 9 of 115 (7.8%) aborted and 2 (1.7%) had ectopic pregnancy.
Mesterolone was found to be more useful in patients with a sperm count ranging
between 5 and 20 million/ml. Those with severe oligospermia (count less than 5
million) do not seem to benefit from this therapy.
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Female
Follicle Stimulating Hormone/blood*
Humans
Luteinizing Hormone/blood*
Male
Mesterolone/pharmacology*
Middle Aged
Oligospermia/blood
Oligospermia/drug therapy*
Pregnancy
Semen/drug effects
Sperm Count/drug effects*
Sperm Motility/drug effects
Testosterone/blood*
Time Factors
Substances:
Mesterolone
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 2892728 [PubMed - indexed for MEDLINE]
2: Clin Endocrinol (Oxf). 1977 May;6(5):339-45.
The hormone response to a synthetic androgen (mesterolone) in oligospermia.
Jackaman FR, Ansell ID, Ghanadian R, McLoughlin PV, Lewis JG, Chisholm GD.
Forty subfertile men with oligospermia were treated with a synthetic androgen
(Mesterolone). The effect of the drug was evaluated by measuring serum
testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH) and
analysing the semen before and after treatment. The results demonstrated that in
twenty-three patients treated for 6-9 months there was a significant decrease in
serum testosterone (P less than 0.01); the means +/- SEM before and after
treatment were 17.05 +/- 0.95 and 14.7 +/- 0.95 (nmol/l serum) respectively.
There was a pronounced increase in serum LH (P less than 0.01), the values being
2.73 +/- 0.26 and 3.61 +/- 0.3 (u/l) respectively. However, no significant
difference was found in serum FSH before and after treatment. The sperm
concentration showed a variable response to treatment. In twenty-one patients
there was either no change or worsening in the sperm concentration, whereas in
nineteen patients an improvement was observed. The analysis of variance of sperm
concentration and motility for the periods before and after treatment, for all
the patients, showed no significant difference in the sperm concentration F1.145
= 2.82 (P=0.1).
Mesh Terms:
Dihydrotestosterone/analogs & derivatives*
Follicle Stimulating Hormone/blood
Humans
Luteinizing Hormone/blood
Male
Mesterolone/therapeutic use*
Oligospermia/blood
Oligospermia/drug therapy*
Semen/drug effects
Testosterone/blood
Substances:
Mesterolone
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 872444 [PubMed - indexed for MEDLINE]
3: Int J Fertil. 1987 Jul-Aug;32(4):306-8.
The effects of mesterolone on sperm count in idiopathic oligospermia.
Bhathena RK, Jassawalla MJ, Patel DN.
Forty subfertile men with idiopathic oligospermia were randomly treated with
mesterolone or with placebo for more than 4 months. Seminal analysis was
performed thrice before treatment, and twice after 16 weeks of treatment. There
was a significant increase of semen volume (P less than .05), mean sperm
concentration (P less than .01), and mean total sperm count per ejaculate (P less
than .01) with mesterolone therapy. Sperm motility and morphological
characteristics were not modified by mesterolone therapy. Mesterolone was found
to be effective in improving the sperm concentration in mild and moderate rather
than in severe idiopathic oligospermia.
Publication Types:
Clinical Trial
Comparative Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Humans
Male
Mesterolone/therapeutic use*
Oligospermia/drug therapy*
Random Allocation
Semen/analysis
Sperm Count/drug effects*
Time Factors
Substances:
Mesterolone
Dihydrotestosterone
PMID: 2887529 [PubMed - indexed for MEDLINE]
4: Fertil Steril. 1991 Mar;55(3):603-7.
Placebo-controlled trial of high-dose Mesterolone treatment of idiopathic male
infertility.
Gerris J, Comhaire F, Hellemans P, Peeters K, Schoonjans F.
Department of Obstetrics and Gynecology, Middleheim General Hospital, Antwerp,
Belgium.
The possible effect of Mesterolone (Schering N.V., Brussels, Belgium) (1
alpha-methyl-5-alpha-androstane-17 beta-ol-3-one) on semen quality and fertility
of men with idiopathic oligoasthenospermia and/or teratozoospermia has been
evaluated in a double-blind trial. The study included 52 patients who were
treated during 12 months with either 150 mg/d of Mesterolone or placebo. The
overall pregnancy rate was similar in the Mesterolone-treated cases (26%) and in
the placebo control cases (48%), although a significant increase in motility and
in the proportion of spermatozoa with normal morphology was recorded in the
Mesterolone-treated cases. Because similar semen improvement also occurred in the
placebo controls, our findings cast doubt on the possible usefulness of high-dose
Mesterolone treatment of idiopathic male infertility.
Publication Types:
Clinical Trial
Multicenter Study
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Mesh Terms:
Administration, Oral
Dihydrotestosterone/blood
Double-Blind Method
Estradiol/blood
Follicle Stimulating Hormone/blood
Humans
Infertility, Male/drug therapy*
Luteinizing Hormone/blood
Male
Mesterolone/pharmacology*
Semen/drug effects
Sperm Count/drug effects
Sperm Motility/drug effects
Testosterone/blood
Time Factors
Substances:
Mesterolone
Estradiol
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 1900485 [PubMed - indexed for MEDLINE]
5: Eur Urol. 1977;3(5):292-4.
Combined mesterolon-clomiphene citrate therapy for treatment of oligospermia.
Bandhauer K, Meili HU.
42 subfertile patients with normal levels of plasma testerone (26 subnormal,
suffering from oligospermia) have been treated with a combination of clomiphene
citrate (50 mg Clomid daily) and mesterolon (50 mg Proviron daily) over a period
of at least 3-6 months. The treatment resulted in pregnancy in 6 cases and in a
significant improvement of the sperm count in 16. In 7, however, whilst the sperm
count improved the qualitative results were unsatisfactory as many sperms were
immature. Restricted spermatogenesis and a sperm count below 5 million/ml must be
considered unfavourable but does not constitute a counter-indication to the
combined therapy. No hazardous complications were observed.
Mesh Terms:
Cell Count
Clomiphene/administration & dosage*
Clomiphene/therapeutic use
Dihydrotestosterone/analogs & derivatives*
Drug Therapy, Combination
Female
Follicle Stimulating Hormone/blood
Humans
Luteinizing Hormone/blood
Male
Mesterolone/administration & dosage*
Mesterolone/therapeutic use
Oligospermia/blood
Oligospermia/drug therapy*
Pregnancy
Spermatogenesis
Spermatozoa
Substances:
Mesterolone
Dihydrotestosterone
Luteinizing Hormone
Follicle Stimulating Hormone
Clomiphene
PMID: 913461 [PubMed - indexed for MEDLINE]
6: Int Urol Nephrol. 1978;10(3):251-6.
Mesterolone treatment of patients with pathospermia.
Szöllösi J, Falkay GY, Sas M.
The response to Mesterolone, in doses of 25 mg/day, was examined in 42
pathospermic patients. Treatment lasted for 100 days. The pronounced response to
the Mesterolone treatment was observed in hypozoo- and oligozoospermia with low
initial fructose content in the ejaculate. Fructose content attained its normal
range after the treatment. During the therapeutic period 11 wives became
pregnant. The authors conclude that Mesterolone does not influence plasma FSH, LH
and testosterone levels, it has only peripheral effects.
Mesh Terms:
Adult
Dihydrotestosterone/analogs & derivatives*
Follicle Stimulating Hormone/blood
Fructose/analysis
Humans
Luteinizing Hormone/blood
Male
Mesterolone/administration & dosage
Mesterolone/therapeutic use*
Oligospermia/drug therapy*
Spermatozoa/analysis
Testosterone/blood
Substances:
Mesterolone
Fructose
Dihydrotestosterone
Testosterone
Luteinizing Hormone
Follicle Stimulating Hormone
PMID: 689818 [PubMed - indexed for MEDLINE]
bluefawnpitbull
bluefawnpitbull
For sure. But if placebo group results = drug group results....By definition, drug has no efficacy. Drug doesn't work. Its all good. Just really obvious that prov is not a preferred drug for the specific purpose of rasing sperm count.
bluefawnpitbull
bluefawnpitbull
Gotcha brother, my mistake. Like the placebo pro-v comment...lol
