Sensitive to lower Estradiol................................

[Alpin]

Ever since lowering my T dose from 70 mg E3D to 60 mg E3D, it's obvious E2 has come down on it's own. Reason I lowered T from 70 mg is because I was at 1270 ng/dl trough.....FYI.
I'm not retaining water, BP ain't high e.t.c.
Still take my HCG E3D at 500 i.u. I use to take 0.25 mg ADEX E4D when at 70 mg E3D of T and seen my E2 at 36.5 pg/ml(regular panel)
Started slicing the quarter tabs of 0.25 mg ADEX in half 2 weeks ago!!
So the dose for ADEX now would be 0.125 mg. I thought this was a very low and safe dose.
I am on a gram of HCG per week (roughly) and two separate jabs of T at 60 mg a piece.
I lowered my E2 too much today. Started feeling shakey, nervous, face went white, heart pounding and no appetite at all from 6 pm and on this afternoon. I took it at quarter to five this afternoon.
I'm thinking my body doesn't really need ADEX or it is not creating too much excess Estradiol with my current protocol.
I'm sure the E3D dose of HCG washes out estradiol wise and there is not much E2 accumulation with that dose.
Went to gym and worked out for 2.5 hrs tonight!!!
and finally relaxed now....had to pop some klonopin.
My joints aren't in pain but I can hear them making slight grinding sounds as I climb/go down a flight of stairs tonight....

When I was on E4D ADEX at 0.25 mg (as listed on top) I never had a problem with anxiety and the T dose was much higher.
My body probably doesn't do well to lower E2.
One other logical explanation is.....ADEX has a longer half life and EOD dosing might be too much, even if the dose is 1/8th of an ADEX tab!!!!
I've leaned out as well since last fall....
anyone have a explanation ?
I've heard some guys can't tolerate ADEX at all on TRT....
It's not like I'm doing concentrated doses of T injections where E2 is going to come up through the roof....
I shoot 60 mg E3D...
????

 

[JOWS7]

That's a lot of assumptions. Sounds like anxiety which I'm betting you have since a bottle of Klonopin was nearby.

 

[Alpin]

I was doing a lot better on E4D of it.
Lowered my dose of paxil and been on this lower dose for a year now.
I was fine yesterday and this afternoon....

 

[JOWS7]

Until you have labs in front of you, you shouldn't assume your E2 is low relative to your previous protocol. Your current dose of 0.125mg E3D is a lower dose than your previous dosage. You cannot state unequivocally that your E2 is now lower despite reducing your T dosage from 70 mg to 60 mg. Again, you are assuming way too much.

I'll assume something here as well: you're seeking some type of argument for your newfound and unwanted anxiety for some comfort.

 

[jomamma007]

Honestly without labs it's all speculation. But even with a total T around 1100, .25mg arimidex would crash my estrogen to 10(regular panel) from over 50(7-42.6).
Personally, I cannot tolerate any ai's on trt without bringing estrogen too low. Just took Aromasin on monday and every day after estrogens been going down, since I haven't injected yet. Skins drying up, weights going down(can't hold any water), tons of problems.

Anywho why don't you lower your hcg dosage to 250iu 2x per week, even 200iu and drop the ai completely? Very few guys need that high a dose. I'd even lower your dosage to give you a 8-900 test level. A 1270 trough is way to high. If you lower both test and hcg dosage you should be able to forgo the ai altogether and not have to deal with the ups and downs of high and low estrogen. Don't think an extra 200 points from 800 to 1000 is going to do squat other then cause estrogen problems. Once your in the upper 1/3 of the range, you wont feel a difference between a few hundred points.

 

[louman]

I was doing a lot better on E4D of it.
Lowered my dose of paxil and been on this lower dose for a year now.
I was fine yesterday and this afternoon....

How do u like Paxil? I was on zoloft bit hadro get off after a month. Was throwing up, no sex drive, ED, and hard to get going in the itst half of dY very zombie like.

 

[Alpin]

Honestly without labs it's all speculation. But even with a total T around 1100, .25mg arimidex would crash my estrogen to 10(regular panel) from over 50(7-42.6).
Personally, I cannot tolerate any ai's on trt without bringing estrogen too low. Just took Aromasin on monday and every day after estrogens been going down, since I haven't injected yet. Skins drying up, weights going down(can't hold any water), tons of problems.

Anywho why don't you lower your hcg dosage to 250iu 2x per week, even 200iu and drop the ai completely? Very few guys need that high a dose. I'd even lower your dosage to give you a 8-900 test level. A 1270 trough is way to high. If you lower both test and hcg dosage you should be able to forgo the ai altogether and not have to deal with the ups and downs of high and low estrogen. Don't think an extra 200 points from 800 to 1000 is going to do squat other then cause estrogen problems. Once your in the upper 1/3 of the range, you wont feel a difference between a few hundred points.

I'm thinking this is my problem....
I absolutely crashed my E2 when first hoping on TRT in October with 0.25 mg ADEX EOD....worse than last night.
Backed off the stuff for a week and then started E4D on it and everything improved. Split up the T shots as well.
ADEX has to have a longer half life than EOD...imo. I've never had anxiety problems with E4D dosing....
that's why I split the 0.25 mg in half to get the 0.125 mg dose!!!
Ideally this 0.125 mg should be run E3D....but that may be too strong as well.
I can't be aromatizing that much with E3D shots of 60 mg....EOD dosing of HCG raises more E2 than E3D....
I wish I could run labs but the doc I go to only gives them once every 18 months....
My GP was the one who ran a lot of labs, but we had a fallout with all this low T....
he refused to treat it or acknowledge it as a problem. long story.

 

[Alpin]

Can anyone tell me how far from an IM shot of HCG or T will Estradiol spike ?

 

[Alpin]

How do u like Paxil? .

it's ok

 

[Alpin]

Honestly without labs it's all speculation. But even with a total T around 1100, .25mg arimidex would crash my estrogen to 10(regular panel) from over 50(7-42.6).
Personally, I cannot tolerate any ai's on trt without bringing estrogen too low. Just took Aromasin on monday and every day after estrogens been going down, since I haven't injected yet. Skins drying up, weights going down(can't hold any water), tons of problems.

I assume you have run thorough labs to verify all this ?
wow that is low E2. Was that the day after taking the 0.25 mg ADEX you were at 10 pg/ml ?
that would be 36 pmol/l in my lab here....
They can't measure anything less than 46 pmol/l
So, yeah I'd def. say you crashed your E2
So what are you doing now to control E2 ?