THE-DET-OAK
IncreasedMyT @ ULV
Shooting HCG more than once a week is a waste?
The following is an interesting study done on humans by the endocrinology society. What im getting from it is since HCG peaks T 2 times after a single injection that it is pointless to shoot more than once a week. So a single shot of 1000iu once per week should do the job. Im sorry i dont have the full study, you have to pay for it.
what do you guys think? BTW this study was done earlier this year.
This was posted by mars1970 on another forum.
Here's the abstract from the pay per view article taken from my sticky on another forum.
Here is the science behind this protocol:
An in vivo injection or an episode of LH secretion induced by GnRH, results in stimulation of the side-chain cleavage enzyme with the subsequent release of testosterone within 30-60 minutes of LH stimulation. The acute response to an injection of LH is dramatic in some species such as the rat and the ram but is much more attenuated in the human. This testosterone response lasts approximately 24-48 hours. If human chorionic gonadotrophin is used as an LH substitute, the kinetics of the initial stimulation are similar to LH but a second peak of testosterone secretion is evidence with hCG and occurs 48-72 hours after the initial injection. This biphasic pattern has been attributed to the observation that between 24 and 48 hours after an LH or hCG injection, the Leydig cells are refractory to further stimulation by either hormone. The second phase of testosterone secretion after hCG but not LH is associated with the longer half-life of hCG in comparison to LH. The hCG levels persist in the circulation and, following recovery from the refractoriness, testosterone levels increase. This observation has significant clinical importance since, in many men, a single weekly injection of hCG will suffice to maintain optimum testosterone responses rather than the frequent practice of giving injections of hCG two to three times per week.
It is advisable to start this protocol around week 3-4 in the cycle, thereby running it for around 6-8wks.
The following is an interesting study done on humans by the endocrinology society. What im getting from it is since HCG peaks T 2 times after a single injection that it is pointless to shoot more than once a week. So a single shot of 1000iu once per week should do the job. Im sorry i dont have the full study, you have to pay for it.
what do you guys think? BTW this study was done earlier this year.
This was posted by mars1970 on another forum.
Here's the abstract from the pay per view article taken from my sticky on another forum.
Here is the science behind this protocol:
An in vivo injection or an episode of LH secretion induced by GnRH, results in stimulation of the side-chain cleavage enzyme with the subsequent release of testosterone within 30-60 minutes of LH stimulation. The acute response to an injection of LH is dramatic in some species such as the rat and the ram but is much more attenuated in the human. This testosterone response lasts approximately 24-48 hours. If human chorionic gonadotrophin is used as an LH substitute, the kinetics of the initial stimulation are similar to LH but a second peak of testosterone secretion is evidence with hCG and occurs 48-72 hours after the initial injection. This biphasic pattern has been attributed to the observation that between 24 and 48 hours after an LH or hCG injection, the Leydig cells are refractory to further stimulation by either hormone. The second phase of testosterone secretion after hCG but not LH is associated with the longer half-life of hCG in comparison to LH. The hCG levels persist in the circulation and, following recovery from the refractoriness, testosterone levels increase. This observation has significant clinical importance since, in many men, a single weekly injection of hCG will suffice to maintain optimum testosterone responses rather than the frequent practice of giving injections of hCG two to three times per week.
It is advisable to start this protocol around week 3-4 in the cycle, thereby running it for around 6-8wks.
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