supergirl
New member
I was able, with the help of ZEN42 better understand the relationship between transdermals and tren....
The primary concern for a transdermal to be effective is the molecular weight of a molecule. Trenbolone's molecular weight is 270, Trenbolone Acetate is 312. To compare with other molecules used in transdermal applications... progesterone is 314 (birth control) and finastride is 373 (propecia).
Here's one study...
J Pharm Pharmacol 2000 Apr;52(4):369-75
Skin permeation of testosterone and its ester derivatives in rats.
Kim MK, Lee CH, Kim DD.
College of Pharmacy, Pusan National University, South Korea.
To establish the optimum conditions for improving the transdermal delivery of testosterone, we studied the relationship between the lipophilicity of testosterone ester derivatives and the rat skin permeation rate of testosterone. We performed a rat skin permeation study of testosterone and its commercially available ester derivatives, testosterone hemisuccinate, testosterone propionate and testosterone-17beta-cypionate, using an ethanol/water co-solvent system. The aqueous solubility and rat skin permeation rate of each drug, saturated in various compositions of an ethanol/water system, was determined at 37 degrees C. The aqueous solubility of testosterone and its ester derivatives increased exponentially as the volume fraction of ethanol increased up to 100% (v/v). The stability of testosterone propionate in both the skin homogenate and the extract was investigated to observe the enzymatic degradation during the skin permeation process. Testosterone propionate was found to b
e stable in the isotonic buffer solution and in the epidermis-side extract for 10h at 37 degrees C. However, in the skin homogenate and the dermis-side extract testosterone propionate rapidly degraded producing testosterone, implying that testosterone propionate rapidly degraded to testosterone during the skin permeation process. The steady-state permeation rates of testosterone in the ethanol/water systems increased exponentially as the volume fraction of ethanol increased, reaching the maximum value (2.69+/-0.69 microg cm(-2)h(-1)) at 70% (v/v) ethanol in water, and then decreasing with further increases in the ethanol volume fraction. However, in the skin permeation study with testosterone esters saturated in 70% (v/v) ethanol in water system, testosterone esters were hardly detected in the receptor solution, probably due to the rapid degradation to testosterone during the skin permeation process. Moreover, a parabolic relationship was observed between the permeation rate
of testosterone and the log P values of ester derivatives. Maximum flux was achieved at a log P value of around 3 which corresponded to that of testosterone (log P = 3.4). The results showed that the skin permeation rate of testosterone and its ester derivatives was maximized when these compounds were saturated in a 70% ethanolic solution. It was also found that a log P value of around 3 is suitable for the skin permeation of testosterone related compounds.
PMID: 10813545
What this study shows several things:
1. That 70% alcohol works as a transdermal.
2. The esterfied steroids work as transdermals. (Test Cyp has molecular weight of 412).
3. The ester appears to have been stripped by the skin (more later).
4. Note the reference of log(p). Log(p) is a critical element. (TA's log(p) is about 3.4)
Regarding the ester being stripped (non-technical term). Hormones are broken down in the body by enzymes. This done by organs. 17AA oral steroids are broken down by the cytocrome p450 enzyme (if I recall correctly) in the kidneys. This is why they are so hard on the kidneys. Trenbolone is known to be broken down by the kidneys and the liver. It may also be broken down by other organs also. To the best of my knowledge, they don't know which enzyme is responsible. There is no evidence that TA is hard on the renal system. So it's not suprising to hear that the ester is broken down by the skin. Skin is an organ!
So you know...once it enters the body, the body strips the ester in Trenbolone Acetate leaving Trenbolone. This is then metabolized into many different metabolites, only three of any real quantity. One of those metabolites is believed to be the main anabolic component of TA. The body then removes these metabolites relatively quickly out of the body. I believe almost all evidence of TA is gone within three weeks.
*****
Here is a critical line from one medical abstract that shows a gel's bioavailability of 61% (I've seen higher).
Maturitas 1999 Jun 21;32(2):103-13
Absorption and bioavailability of oestradiol from a gel, a patch and a tablet.
...The bioavailability of oestradiol from the gel was 61% as compared with the tablet...
So anybody who says only 10% bioavailability doesn't know what they are talking about.
*****
i hope this has helped some of you better understand the way tren can work with a transdermal or any compound with a molecular weight viable for a transdermal...
Luv super
The primary concern for a transdermal to be effective is the molecular weight of a molecule. Trenbolone's molecular weight is 270, Trenbolone Acetate is 312. To compare with other molecules used in transdermal applications... progesterone is 314 (birth control) and finastride is 373 (propecia).
Here's one study...
J Pharm Pharmacol 2000 Apr;52(4):369-75
Skin permeation of testosterone and its ester derivatives in rats.
Kim MK, Lee CH, Kim DD.
College of Pharmacy, Pusan National University, South Korea.
To establish the optimum conditions for improving the transdermal delivery of testosterone, we studied the relationship between the lipophilicity of testosterone ester derivatives and the rat skin permeation rate of testosterone. We performed a rat skin permeation study of testosterone and its commercially available ester derivatives, testosterone hemisuccinate, testosterone propionate and testosterone-17beta-cypionate, using an ethanol/water co-solvent system. The aqueous solubility and rat skin permeation rate of each drug, saturated in various compositions of an ethanol/water system, was determined at 37 degrees C. The aqueous solubility of testosterone and its ester derivatives increased exponentially as the volume fraction of ethanol increased up to 100% (v/v). The stability of testosterone propionate in both the skin homogenate and the extract was investigated to observe the enzymatic degradation during the skin permeation process. Testosterone propionate was found to b
e stable in the isotonic buffer solution and in the epidermis-side extract for 10h at 37 degrees C. However, in the skin homogenate and the dermis-side extract testosterone propionate rapidly degraded producing testosterone, implying that testosterone propionate rapidly degraded to testosterone during the skin permeation process. The steady-state permeation rates of testosterone in the ethanol/water systems increased exponentially as the volume fraction of ethanol increased, reaching the maximum value (2.69+/-0.69 microg cm(-2)h(-1)) at 70% (v/v) ethanol in water, and then decreasing with further increases in the ethanol volume fraction. However, in the skin permeation study with testosterone esters saturated in 70% (v/v) ethanol in water system, testosterone esters were hardly detected in the receptor solution, probably due to the rapid degradation to testosterone during the skin permeation process. Moreover, a parabolic relationship was observed between the permeation rate
of testosterone and the log P values of ester derivatives. Maximum flux was achieved at a log P value of around 3 which corresponded to that of testosterone (log P = 3.4). The results showed that the skin permeation rate of testosterone and its ester derivatives was maximized when these compounds were saturated in a 70% ethanolic solution. It was also found that a log P value of around 3 is suitable for the skin permeation of testosterone related compounds.
PMID: 10813545
What this study shows several things:
1. That 70% alcohol works as a transdermal.
2. The esterfied steroids work as transdermals. (Test Cyp has molecular weight of 412).
3. The ester appears to have been stripped by the skin (more later).
4. Note the reference of log(p). Log(p) is a critical element. (TA's log(p) is about 3.4)
Regarding the ester being stripped (non-technical term). Hormones are broken down in the body by enzymes. This done by organs. 17AA oral steroids are broken down by the cytocrome p450 enzyme (if I recall correctly) in the kidneys. This is why they are so hard on the kidneys. Trenbolone is known to be broken down by the kidneys and the liver. It may also be broken down by other organs also. To the best of my knowledge, they don't know which enzyme is responsible. There is no evidence that TA is hard on the renal system. So it's not suprising to hear that the ester is broken down by the skin. Skin is an organ!
So you know...once it enters the body, the body strips the ester in Trenbolone Acetate leaving Trenbolone. This is then metabolized into many different metabolites, only three of any real quantity. One of those metabolites is believed to be the main anabolic component of TA. The body then removes these metabolites relatively quickly out of the body. I believe almost all evidence of TA is gone within three weeks.
*****
Here is a critical line from one medical abstract that shows a gel's bioavailability of 61% (I've seen higher).
Maturitas 1999 Jun 21;32(2):103-13
Absorption and bioavailability of oestradiol from a gel, a patch and a tablet.
...The bioavailability of oestradiol from the gel was 61% as compared with the tablet...
So anybody who says only 10% bioavailability doesn't know what they are talking about.
*****
i hope this has helped some of you better understand the way tren can work with a transdermal or any compound with a molecular weight viable for a transdermal...
Luv super
good to have you here!!!
