Why do I need to pee so much?

[ButtersStoch]

Hi, this forum seems pretty well informed & this may relate to TRT, so thanks in advance for taking an interest in helping. Here is some background information(it will take a little bit, but it's worth it in terms of helping)

Right now I'm urinating at least 25x per day & sometimes it's difficulty to get the pee going. I have told multiple doctors about this & even seen a urologist(who seems pretty good) several times.

I'm 31 years old, Male & have cycled anabolics on & off for at least 5 years. I'm on TRT & that was before using any anabolics(by an endo, not self administered). I'm also on Suboxone. As for the cause of Low levels, I dont know, but the closest thing I can think of is that I have been on 25+ psychiatric medications & also had electro convulsive therapy.

I've had this pee issue with slowly increasing frequency for 2-3 years. Since I was on a medication called Ketamine(for depression) & a top symptom of that drug is urinary frequency etc, it was always assumed that this was causing it. About 3 months ago, I got off the Ketamine. Since than I'm peeing a bit more often, rather than far less.

So it seems like Testosterone is the obvious reason, but I'm not sure & here is why. When I went to the urologist, they put a camera up my bladder & checked my pee. She also did a prostate exam & my PSA was checked. My bladder was healthy, I didn't have a UTI, my PSA was fine & my Prostate was normal size.


Another piece of information that may help is this: I tried Stanazolol, Dianabol, Anavar & Trenbolone in the past year(for 3 weeks, 3 days, 3 days & 1 week, respectively). Each time these bady upped the symptoms by at least double & I quickly stopped. The symptoms would persist for about 2-3 times the duration of the drug taken(3 days on would take a 10+ days to start receding).

Interestingly, I had tried Dianabol & Trenbolone for much longer periods about 3 years ago, with no pee symptoms. Also, Im cycling Testosterone at a higher than TRT dosage in the past 2 months.(However, I've had similar symptoms when using the normal TRT dose).

I have told doctors everything except the last 2 months using Test. My psychiatrist prescribed a tricyclic drug called imipramine to help with urinary symptoms & I just dropped the script off. He is very good & thought it might not be testosterone, but part of a systemic illness(since I've had depression, anxiety, chronic fatigue, insomnia etc)

Since the more powerful androgens caused it to flare up so fast(Dianabol, anavar etc) I thought it could be related, but 2-3 days isnt enough time to cause hypertrophy in the prostate. Everything I've researched about androgens/testosterone causing people to pee, seems to all go back prostate though.

What do you think it might be? If this has given you more questions feel free to ask. I tried to be 100% authentic, honest & comprehensive as possible, but I think I have to go pee now!

Thanks, Butters

 

[Megatron28]

Can you post your most recent blood work? TT, E2, CBC and Metbolic Profile. I would like to see how your hormones and kidneys look.

 

[juced_porkchop]

with or without trt, it could be prostate, have you gotten your prostate checked? i have the feeling no... go check that

also maybe this is of interest to you>
https://www.youtube.com/watch?v=Z0JPunoP6Io&index=20&list=PLS1Q20P0IXg3V5lbx7DhBq1AIJZzvwI0f
https://www.youtube.com/playlist?list=PLS1Q20P0IXg3V5lbx7DhBq1AIJZzvwI0f

 

[ButtersStoch]

Can you post your most recent blood work? TT, E2, CBC and Metbolic Profile. I would like to see how your hormones and kidneys look.

Yes, Im on a mobile Apple device though, PC will be much faster.

To Porkchop, my doctor gave me a thorough prostate exam. They also put a camera up my bladder(this makes a prostate exam feel good comparatively). She said my bladder is very healthy & my prostate is normal sized.(it's in original post)

I didn't ask her about irritation, but it wasn't mentioned. Another thing the Suboxone, although its rare...I've read ppl having a similar issue on forums involving that drug.

 

[cybrsage]

Do you drink a lot of water? I pee a LOT, but I also drink about a gallon of water a day. That means I have to pee out roughly that much to maintain the balance.

 

[halfwit]

I know you've had it examined (I'd imagine a digital), and a PSA - but I would give cialis a try. Prostatitis (inflammation of the prostate) is not always easy to detect, but the symptoms you're experiencing ring a bell for me.

At least talk to your doc about it. Especially if you have estradiol problems, which is common in poorly run trt protocols or AAS cycles.

My .02c

 

[ButtersStoch]

Ok here is the bloodwork, they don't show things like Total Test, Free Test, Estradiol. Unless, you physically go to the medical records department, sign for it & have them print it out. Good news is, I remember 2 out of 3 of them. Total Testosterone being 990 ng/dl(June 13th)which was just under their top level. My Free Testosterone was almost 3x the top level. I have no clue what E2 is, they didn't test it.

Also ALT, AST, Prolactin were a little high. My Endo didn't think it was high enough to actually cause any sort of serious symptoms, just a little high. She was fine with the numbers on Free Test & Total Test. At the time of the test, I was still on Ketamine. All the doctors(& myself) thought that was the reason for me peeing so often.

My old Endocrinologist had me on a 50% lower dosage & my Test was between 300-400ng/dl. He was focused on diabetic obesity, seemed creepy & was generally anti-TRT, so I switched & they upped the dose(I didn't ask them, I just wanted a new one). They current one tested for alot more things, but not Estradiol.

Total Protein Serum
Date
June 13, 2014 05:40 p.m. PDT
Result
6.5 g/dL
Normal: 6.2 g/dL - 8.1 g/dL

Potassium Serum
Date
June 13, 2014 05:40 p.m. PDT
Result
4.4 mmol/L
Normal: 3.6 mmol/L - 5.3 mmol/L

Urea Nitrogen
Date
June 13, 2014 05:40 p.m. PDT
Result
27 mg/dL (High)
Normal: 9 mg/dL - 25 mg/dL

AST (SGOT)
Date
June 13, 2014 05:40 p.m. PDT
Result
47 U/L (High)
Normal: 10 U/L - 40 U/L

ALT (SGPT)
Date
June 13, 2014 05:40 p.m. PDT
Result
82 U/L (High)
Normal: <= 55 U/L

Thyroid Stimulating Hormone
Date
June 13, 2014 05:40 p.m. PDT
Result
1.17 mIU/L
Normal: 0.35 mIU/L - 4.94 mIU/L

Sodium Level
Date
June 13, 2014 05:40 p.m. PDT
Result
141 mmol/L
Normal: 136 mmol/L - 146 mmol/L

PSA - Total
Date
June 13, 2014 05:40 p.m. PDT
Result
0.54 ng/mL
Normal: <= 2.50 ng/mL

Glucose Random
Date
June 13, 2014 05:40 p.m. PDT
Result
90 mg/dL
Normal: 75 mg/dL - 139 mg/dL

Thyroxine (T4) Free
Date
June 13, 2014 05:40 p.m. PDT
Result
0.91 ng/dL
Normal: 0.70 ng/dL - 1.48 ng/dL

Direct Bilirubin
Date
June 13, 2014 05:40 p.m. PDT
Result
0.2 mg/dL
Normal: 0.1 mg/dL - 0.5 mg/dL

CREATININE
Date
June 13, 2014 05:40 p.m. PDT
Result
1.18 mg/dL
Normal: 0.72 mg/dL - 1.25 mg/dL

Chloride Level
Date
June 13, 2014 05:40 p.m. PDT
Result
102 mmol/L
Normal: 100 mmol/L - 112 mmol/L

Carbon Dioxide Content (CO2)
Date
June 13, 2014 05:40 p.m. PDT
Result
30 mmol/L
Normal: 22 mmol/L - 31 mmol/L

Calcium Level
Date
June 13, 2014 05:40 p.m. PDT
Result
9.7 mg/dL
Normal: 8.7 mg/dL - 10.4 mg/dL

Bilirubin Total Level
Date
June 13, 2014 05:40 p.m. PDT
Result
0.4 mg/dL
Normal: 0.2 mg/dL - 1.2 mg/dL

Anion Gap, Blood
Date
June 13, 2014 05:40 p.m. PDT
Result
9 mmol/L
Normal: 6 mmol/L - 14 mmol/L

Alkaline Phosphatase
Date
June 13, 2014 05:40 p.m. PDT
Result
46 U/L
Normal: 40 U/L - 150 U/L

Albumin Level
Date
June 13, 2014 05:40 p.m. PDT
Result
4.1 g/dL
Normal: 3.5 g/dL - 5.0 g/dL

Prolactin Level, Serum
Date
June 13, 2014 05:18 p.m. PDT
Result
17.0 ng/mL (High)
Normal: 2.8 ng/mL - 15.6 ng/mL

Cortisol Level, Random
Date
June 13, 2014 05:09 p.m. PDT
Result
9.4 mcg/dL

Luteinizing Hormone Level, LH
Date
May 12, 2014 07:07 p.m. PDT
Result
< 0.5 mIU/mL (Low)
Normal: 0.6 mIU/mL - 12.1 mIU/mL

Here's from November, 2013:

AST (SGOT)
Date
Nov. 21, 2013 06:18 p.m. PST
Result
40 U/L
Normal: 10 U/L - 40 U/L

ALT (SGPT)
Date
Nov. 21, 2013 06:18 p.m. PST
Result
46 U/L
Normal: <= 55 U/L

PSA - Total
Date
Nov. 21, 2013 06:18 p.m. PST
Result
0.28 ng/mL
Normal: <= 2.50 ng/mL

Once again, I did have my prostate examined & it was normal size & I didn't have a UTI(Urinary Tract Infection). The prostate exam & bladder exam were done by my Urologist(she is not the same doctor as the Endocrinologist, who did the above test). I have told both of them about it I haven't had an appointment with either since going off the Ketamine. So they are probably still under the impression that is it.

I told my psychiatrist about 2 days ago, he put me on imipramine(which I'm starting tonight, for the pee thing). He is not a typical psychiatrist & he does understand hormones pretty well.

 

[MBB]

Based off your bloodwork (the top one is the most recent I assume, but I did just breeze over it) it looks like you could have an underlying issues with your kidneys and/or liver. Both of which can increase urinary frequency. What's the urgency like? Do you get the urge to pee suddenly and desperately? If so I'd definitely be leaning toward the kidney/liver area (I speak as someone with experience). Does your urine have an odour? Is there any pain when urinating. Unfortunately I can't be more specific as to whether it is a kidney or a liver issue as the two can often overlap, or one can exacerbate the other.

 

[ButtersStoch]

Based off your bloodwork (the top one is the most recent I assume, but I did just breeze over it) it looks like you could have an underlying issues with your kidneys and/or liver. Both of which can increase urinary frequency. What's the urgency like? Do you get the urge to pee suddenly and desperately? If so I'd definitely be leaning toward the kidney/liver area (I speak as someone with experience). Does your urine have an odour? Is there any pain when urinating. Unfortunately I can't be more specific as to whether it is a kidney or a liver issue as the two can often overlap, or one can exacerbate the other.

Usually not *suddenly* & definitely not desperately(unless I drink alot of fluids in a short period & wait a few hours). Once I empty my bladder, I feel the urge to go slowly rising within 15-20 minutes..until it becomes somewhat uncomfortable. I can't really tell if it has an odor, maybe. I got a plastic thing to pee into from the hospital(so you don't have to go to the bathroom every time) & if I don't empty it, it does start to smell(although if you left 500ml of pee sitting around awhile, wouldn't it be normal to smell after awhile?).

It is *not* painful at all, just difficult to get started. It's more like an itch that you need to eventually scratch, than an acute "pain". Also, there is no burning.

I actually can't wet myself. It's basically impossible.

Not saying it's not this, but I don't think I have most of these symptoms.

 

[Megatron28]

Here are my thoughts:

Creatinine looks good. Did you get eGFR?

AST/ALT are high: I would take 1000mg of NAC daily. You can get this over the counter. I get mine on Amazon.

Prolactin was a little high: I would talk to your doc about that. What was it at before you started TRT? Did you ever have an MRI of your pituitary done?

What was your estradiol at?

 

[ButtersStoch]

Here are my thoughts:

Creatinine looks good. Did you get eGFR?

AST/ALT are high: I would take 1000mg of NAC daily. You can get this over the counter. I get mine on Amazon.

Prolactin was a little high: I would talk to your doc about that. What was it at before you started TRT? Did you ever have an MRI of your pituitary done?

What was your estradiol at?

Hi, Megatron.
I didn't get eGFR or Estradiol. I agree, that it would be good to get my liver/kidney values lower. They fluctuate, sometimes they are high, sometimes in range. Are there studies that show NAC helps?

My Prolactin was never tested before TRT. This doctor was the first to test it & she brought it up with me. However, the bloodwork before this one had it at around 26 ng/pl & the endo said she would wait to test it again, before doing a MRI of the pituitary. If it was still high she would order the MRI. Since it improved by almost 10 points she decided not to.

I had taken Nandrolone & Risperidone(100-200mg per week, 1mg off & on) when it was high & in the 2nd test, I didnt use either. Risperidone is known to elevate Prolactin(I think Nandrolone can too). I told her this & that I went off. She decided I didn't need one, because it dropped a lot after I stopped taking them.

Thanks Megatron,

Butters

 

[Megatron28]

Are there studies on NAC and the liver. I would presume so. Look them up. Pretty much everyone here will tell you it helps your liver. It is what they give people in the hospital for Tylenol poisoning. I have used it personally and it worked for me.

Yes, Nandrolone can definitely increase Prolactin values if estradiol is high. You shouldn't neglect to leave facts like that out. Nandrolone can also affect your kidneys. Did you not use a dopamine agonist while running Nandrolone?

Always. Always check estradiol while using exogenous testosterone. You have been around f here long enough to know that.

 

[ButtersStoch]

Are there studies on NAC and the liver. I would presume so. Look them up. Pretty much everyone here will tell you it helps your liver. It is what they give people in the hospital for Tylenol poisoning. I have used it personally and it worked for me.

Yes, Nandrolone can definitely increase Prolactin values if estradiol is high. You shouldn't neglect to leave facts like that out. Nandrolone can also affect your kidneys. Did you not use a dopamine agonist while running Nandrolone?

Always. Always check estradiol while using exogenous testosterone. You have been around f here long enough to know that.

Hey Megatron
I wasn't using a dopamine agonist & my estradiol has never been checked in my memory. Ive tried to include everything I can remember. I had ECT(electro convulsive therapy) for 31 session & they caused a *lot* of memory damage(retrograde & anterograde amnesia).

I don't select what they test for, but I can ask her to test Estradiol next time.

Thanks Megatron