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Ok personally I am not a big fan of nolva, however its a fact that nolva is never going to just up and go the hell away. So with this in mind have put together a few facts about nolva and things I feel should be taken into consideration when using nolva.
1. Nolva/clomid both raise shbg.
This is something I do not see a lot of people disusing so I I wanted to make it well know. Just do a web search on TAMOXIFEN,clomid or nolva raises shbg or any variation and you will get all the studies and prof you need.
Trait Anxiety and Tamoxifen Effects on Bone Mineral Density and Sex Hormone- Binding Globulin -- Cameron et al. 64 (4): 612 -- Psychosomatic Medicine
iHOP - Information Hyperlinked over Proteins [ SHBG ]
Sex Hormone Binding Globulin in Clinical Perspective; Acta Obstetricia et Gynecologica Scandinavica - 66(3)
ages 255-262 - Informa Healthcare
Wiley InterScience :: Session Cookies
2. Nolva lowers Igf-1 Again just a simple search on (TAMOXIFEN or nolva lowers IGF 1 and walla you got all the prof you need.
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
3. Nolva or clomid do not lower estrogen!!!!!!!! And when you come off of its not uncommon to have a estrogen rebound.
4. They can cause Major triglyceride and glucose problems and even to the point of Severe hypertriglyceridemia or also Pancreatitis
Severe hypertriglyceridemia caused by tamoxifen-tr... [Endocr J. 1997] - PubMed result
Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus - EM|consulte
SpringerLink - Journal Article
Capecitabine-Induced Severe Hypertriglyceridemia: Report of Two Cases -- Kurt et al. 40 (2): 328 -- The Annals of Pharmacotherapy
Elsevier: Article Locator
Estrogen and Triglycerides
http://annonc.oxfordjournals.org/cgi/reprint/11/8/1067.pdf
WikiGenes - Hypertriglyceridemia
So Yes I have heard it all before that clomid and nolva work to help recover HPTA. That is great and I am not arguing that fact. However This still does not negate these 4 simple facts ^^^^ and for the people who love to scream test results,test results test results. Well here Here ya go ^^^ test results, enjoy the:biggrin: . So Even people who love using nolva and clomid for post cycle therapy (pct) should be able to agree that there is room for improvement.
Enter Hcgenerate!!!!!!!!!!!!!
What is HCGenerate?
HCGenerate is a natural testosterone booster that stimulates the body's own production of testosterone. It is totally legal while being the strongest over the counter post cycle therapy (pct) on the market today!
What is it used for?
· Post cycle therapy
· Stimulating sexual arousal
· Prevention of testosterone shutdown
. Natural muscle building cycles
Benefits of HCGenerate:
· helps prevent erectile disfunction
· keeps muscle gains higher
· assists liver function
· promotes better mood and feeling of well being
· prevents rapid reductions in IGF
· increases DHEA and free testosterone
· improves HDL
· totally legal
· no injections
. lowers shbg
.to name a few, however, this is not an all inclusive list of benefits!
HCGenerate:Supplement facts
Serving size: 5 capsules x 30 servings per container.
Fadogia Agrestis.................1000
Fenugreek PE (50% testofen).....1000
3,4 Divanillyltetrahydrofuran....500
Bulgarian Tribulus Terrestre: 500mg
Vitamin E.......................200
LJ:100..........................100
Zinc............................7mg
The first Ingredient in Hcgenerate
Fadogia Agrestis.................1000
http://www.superhumanradio.com/research/Asian J Androl 2005 Fadogia agrestis.pdf
studies have show that it does in fact raise lh levels and testosterone levels. Not only this but be sure to check the feed back threads posted at the end so you can see its effects do work.
The second Ingredient
Fenugreek PE (50% testofen).....1000
This is a cool one because it has been shown to
1. Promote healthy glucose levels and healthy sugar metabolism By assisting the pancreas in production of insulin.
Fenugreek supports healthy blood sugar levels
Fenugreek enters modern medicine
A few more interesting facts about Fenugreek is that it has shown to mimic testosterone by binding to the testosterone receptor sites and creating "testosterone like activity"
Just like nolva can bind to different receptors and "act like" and even "exhibit" estrogen "like activity" yet not lower the bodies estrogen at all well doing so or even suppress estrogen production. So can other things like testofen bind to and "act like" and "exhibit" testosterone "like activity" with out having any effect on test production its self what so ever.
So this works very well during post cycle therapy (pct) when the bodies natural testosterone is low. Helping to prevent the lost of muscle that one gets when coming off of cycle.
The 3rd ingredient
3,4 Divanillyltetrahydrofuran....500
3,4 divan has shown in multiple studies to have the highest binding affinity for SHBG of all lignans investigated thus far,Thus is lowers shbg and increases free test, and we threw in a huge dose of it.
3,4 Divanillyltetrahydrofuran
3,4-Divanillyltetrahydrofuran; A Potent Testosterone Booster
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
3,4 Divanillyltetrahydrofuran also promote the secondary messenger nitric oxide (NO) by increasing its main enzyme eNOS (endothelial nitric oxide synthase). As NO is postulated to be one of the key triggers for muscle cell proliferation and growth while also promoting muscular pumps in the gym, this aspect of3,4 Divanillyltetrahydrofuran leads to fuller muscles that you can see and feel, thus providing significant mental motivation.
4th Bulgarian Tribulus Terrestre: 500mg
Debated for years now. Some swear by it and some say its junk. A few studies have show that it raises test levels and some of disproved this as well. Studies do however show that it Heightens sexual arousal. And I believe this is more do to its Ability to Up regulate androgen/sex hormone receptors in the brain. So in other words it makes them respond better.
ScienceDirect - Journal of Ethnopharmacology : Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain
5th added Ingredient
Vitamin E.......................200
Many studies have shown the Zinc suplamentation can have an positive effect on Igf.
Furthermore we have all seen studies showing V-e's protective effect on Leydig cell steroidogenesis
http://www.sciencedirect.com/science...bf2cc4ac924ab5
6th Add on is
LJ100
LJ100 Eurycoma longifolia extract
Study Indicates LJ100 Eurycoma longifolia extract Safely Promotes Anabolic Balance During Endurance Exercise :: News :: Natural and Nutritional Products Industry Center
About LJ 100®
LJ100® is a standardized, freeze-dried Eurycoma longifolia extract, containing 40% glycosaponins and 22% eurypeptides, a bioactive glycoprotein that is now clinically proven for its androgenic properties. LJ100® has undergone a patented BAT extraction process to capture 22% biologically active eurypeptides, proven in research to be responsible for increasing libido, improving sports performance, increasing fertility, and activating the enzymes that metabolize the various androgens.
Created by the original researchers at the Forest Research Institute of Malaysia (FRIM), University of Malaya, and Massachusetts Institute of Technology, LJ100® (22% bioactive eurypeptides) has shown - in human clinical trials - an ability to increase DHEA and free testosterone, decrease Sex Hormone Binding Globulin (SHBG), improve HDL, modulate cortisol, and increase IGF-1 level.
So its pretty apparent how Hcgenerate counteracts all Negative sides associated with the use of nolva and or clomid, and it the perfect complement for this post cycle therapy (pct) using these drugs. For anyone thinking about using or who has used clomid/nolva for post cycle therapy (pct) I highly recommend you take what I have said into account and add hcgenerate to the mix.
Why settle for the norm or just ok when you can go all the way and get the best of both worlds. IMO hcgenerat is the new "must have" for anyone who runs clomid or nolvadex.
http://www.needtobuildmuscle.net/store/Post-Cycle-Therapy-Support-Supplements/-HCGenerate-p45.html
1. Nolva/clomid both raise shbg.
This is something I do not see a lot of people disusing so I I wanted to make it well know. Just do a web search on TAMOXIFEN,clomid or nolva raises shbg or any variation and you will get all the studies and prof you need.
Trait Anxiety and Tamoxifen Effects on Bone Mineral Density and Sex Hormone- Binding Globulin -- Cameron et al. 64 (4): 612 -- Psychosomatic Medicine
iHOP - Information Hyperlinked over Proteins [ SHBG ]
Sex Hormone Binding Globulin in Clinical Perspective; Acta Obstetricia et Gynecologica Scandinavica - 66(3)
ages 255-262 - Informa HealthcareWiley InterScience :: Session Cookies
2. Nolva lowers Igf-1 Again just a simple search on (TAMOXIFEN or nolva lowers IGF 1 and walla you got all the prof you need.
In This Issue -- 82 (21): 1661 -- JNCI Journal of the National Cancer Institute
http://cancerres.aacrjournals.org/cgi/reprint/49/7/1882.pdf
Effect of low dose tamoxifen on the insulin-like growth factor system in healthy women
Comparison of Tamoxifen and Testosterone Propionate in Male Rats: Differential Prevention of Orchidectomy Effects on Sex Organs, Bone Mass, Growth, and the Growth Hormone-IGF-I Axis -- Fitts et al. 25 (4): 523 -- Journal of Andrology
3. Nolva or clomid do not lower estrogen!!!!!!!! And when you come off of its not uncommon to have a estrogen rebound.
4. They can cause Major triglyceride and glucose problems and even to the point of Severe hypertriglyceridemia or also Pancreatitis
Severe hypertriglyceridemia caused by tamoxifen-tr... [Endocr J. 1997] - PubMed result
Tamoxifen-induced hypertriglyceridemia in association with diabetes mellitus - EM|consulte
SpringerLink - Journal Article
Capecitabine-Induced Severe Hypertriglyceridemia: Report of Two Cases -- Kurt et al. 40 (2): 328 -- The Annals of Pharmacotherapy
Elsevier: Article Locator
Estrogen and Triglycerides
http://annonc.oxfordjournals.org/cgi/reprint/11/8/1067.pdf
WikiGenes - Hypertriglyceridemia
So Yes I have heard it all before that clomid and nolva work to help recover HPTA. That is great and I am not arguing that fact. However This still does not negate these 4 simple facts ^^^^ and for the people who love to scream test results,test results test results. Well here Here ya go ^^^ test results, enjoy the:biggrin: . So Even people who love using nolva and clomid for post cycle therapy (pct) should be able to agree that there is room for improvement.
Enter Hcgenerate!!!!!!!!!!!!!
What is HCGenerate?
HCGenerate is a natural testosterone booster that stimulates the body's own production of testosterone. It is totally legal while being the strongest over the counter post cycle therapy (pct) on the market today!
What is it used for?
· Post cycle therapy
· Stimulating sexual arousal
· Prevention of testosterone shutdown
. Natural muscle building cycles
Benefits of HCGenerate:
· helps prevent erectile disfunction
· keeps muscle gains higher
· assists liver function
· promotes better mood and feeling of well being
· prevents rapid reductions in IGF
· increases DHEA and free testosterone
· improves HDL
· totally legal
· no injections
. lowers shbg
.to name a few, however, this is not an all inclusive list of benefits!
HCGenerate:Supplement facts
Serving size: 5 capsules x 30 servings per container.
Fadogia Agrestis.................1000
Fenugreek PE (50% testofen).....1000
3,4 Divanillyltetrahydrofuran....500
Bulgarian Tribulus Terrestre: 500mg
Vitamin E.......................200
LJ:100..........................100
Zinc............................7mg
The first Ingredient in Hcgenerate
Fadogia Agrestis.................1000
http://www.superhumanradio.com/research/Asian J Androl 2005 Fadogia agrestis.pdf
studies have show that it does in fact raise lh levels and testosterone levels. Not only this but be sure to check the feed back threads posted at the end so you can see its effects do work.
The second Ingredient
Fenugreek PE (50% testofen).....1000
This is a cool one because it has been shown to
1. Promote healthy glucose levels and healthy sugar metabolism By assisting the pancreas in production of insulin.
Fenugreek supports healthy blood sugar levels
Fenugreek enters modern medicine
A few more interesting facts about Fenugreek is that it has shown to mimic testosterone by binding to the testosterone receptor sites and creating "testosterone like activity"
Just like nolva can bind to different receptors and "act like" and even "exhibit" estrogen "like activity" yet not lower the bodies estrogen at all well doing so or even suppress estrogen production. So can other things like testofen bind to and "act like" and "exhibit" testosterone "like activity" with out having any effect on test production its self what so ever.
So this works very well during post cycle therapy (pct) when the bodies natural testosterone is low. Helping to prevent the lost of muscle that one gets when coming off of cycle.
The 3rd ingredient
3,4 Divanillyltetrahydrofuran....500
3,4 divan has shown in multiple studies to have the highest binding affinity for SHBG of all lignans investigated thus far,Thus is lowers shbg and increases free test, and we threw in a huge dose of it.
3,4 Divanillyltetrahydrofuran
3,4-Divanillyltetrahydrofuran; A Potent Testosterone Booster
Interaction of lignans with human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Lignans bind to sex hormone-binding globulin (SHBG). The lignan with the highest binding affinity is (+/ )-3,4-divanillyltetrahydrofuran. In a double Stobbe condensation--without use of protecting groups--a wide variety of lignans with different substitution pattern in the aromatic and aliphatic part of the molecule was synthesized. These lignans were tested in a SHBG-binding assay which allowed to deduce the following relationship between structure and activity: 1) (+/-)-diastereoisomers are more active than meso compounds 2.) the 4-hydroxy-3-methoxy (guajacyl) substitution pattern in the aromatic part is most effective 3.) the activity increases with the decline in polarity of the aliphatic part of the molecule.
Lignans from the roots of Urtica dioica and their metabolites bind to human sex hormone binding globulin (SHBG).
Schottner M, Gansser D, Spiteller G.
Lehrstuhl Organische Chemie I, Universitat Bayreuth, Germany.
Polar extracts of the stinging nettle (Urtica dioica L.) roots contain the ligans (+)-neoolivil, (-) secoisolariciresinol, dehydrodiconiferyl alcohol, isolariciresinol, pinoresinol, and 3,4 divanillyltetrahydrofuran. These compounds were either isolated from Urtica roots, or obtained semisynthetically. Their affinity to human sex hormone binding globulin (SHBG) was tested in an in vitro assay. In addition, the main intestinal transformation products of plant lignans in humans, enterodiol and enterolactone, together with enterofuran were checked for their activity. All lignans except (-) pinoresinol developed a binding affinity to SHBG in the in vitro assay. The affinity of (-)-3,4 divanillyltetrahydrofuran was outstandingly high These findings are discussed with respect to potential beneficial effects of plant lignans on benign prostatic hyperplasia (BPH).
3,4 Divanillyltetrahydrofuran also promote the secondary messenger nitric oxide (NO) by increasing its main enzyme eNOS (endothelial nitric oxide synthase). As NO is postulated to be one of the key triggers for muscle cell proliferation and growth while also promoting muscular pumps in the gym, this aspect of3,4 Divanillyltetrahydrofuran leads to fuller muscles that you can see and feel, thus providing significant mental motivation.
4th Bulgarian Tribulus Terrestre: 500mg
Debated for years now. Some swear by it and some say its junk. A few studies have show that it raises test levels and some of disproved this as well. Studies do however show that it Heightens sexual arousal. And I believe this is more do to its Ability to Up regulate androgen/sex hormone receptors in the brain. So in other words it makes them respond better.
ScienceDirect - Journal of Ethnopharmacology : Effect of Tribulus terrestris on nicotinamide adenine dinucleotide phosphate-diaphorase activity and androgen receptors in rat brain
5th added Ingredient
Vitamin E.......................200
Many studies have shown the Zinc suplamentation can have an positive effect on Igf.
Furthermore we have all seen studies showing V-e's protective effect on Leydig cell steroidogenesis
http://www.sciencedirect.com/science...bf2cc4ac924ab5
6th Add on is
LJ100
LJ100 Eurycoma longifolia extract
Study Indicates LJ100 Eurycoma longifolia extract Safely Promotes Anabolic Balance During Endurance Exercise :: News :: Natural and Nutritional Products Industry Center
About LJ 100®
LJ100® is a standardized, freeze-dried Eurycoma longifolia extract, containing 40% glycosaponins and 22% eurypeptides, a bioactive glycoprotein that is now clinically proven for its androgenic properties. LJ100® has undergone a patented BAT extraction process to capture 22% biologically active eurypeptides, proven in research to be responsible for increasing libido, improving sports performance, increasing fertility, and activating the enzymes that metabolize the various androgens.
Created by the original researchers at the Forest Research Institute of Malaysia (FRIM), University of Malaya, and Massachusetts Institute of Technology, LJ100® (22% bioactive eurypeptides) has shown - in human clinical trials - an ability to increase DHEA and free testosterone, decrease Sex Hormone Binding Globulin (SHBG), improve HDL, modulate cortisol, and increase IGF-1 level.
So its pretty apparent how Hcgenerate counteracts all Negative sides associated with the use of nolva and or clomid, and it the perfect complement for this post cycle therapy (pct) using these drugs. For anyone thinking about using or who has used clomid/nolva for post cycle therapy (pct) I highly recommend you take what I have said into account and add hcgenerate to the mix.
Why settle for the norm or just ok when you can go all the way and get the best of both worlds. IMO hcgenerat is the new "must have" for anyone who runs clomid or nolvadex.
http://www.needtobuildmuscle.net/store/Post-Cycle-Therapy-Support-Supplements/-HCGenerate-p45.html
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