I have always been under the impression, that using steroids will more thna make-up for igf-1 lowering when using a little arimidex or femera. Arimidex being the worse of the two as far as igf-1 lowering, but it seems i was mistaken. IGF-1 is a very intregal part of the reason why steroids work so well. Heres a study on femera I read on CEM this morning, remeber, arimidex is worse than femera as far as lowering IGF-1.
"The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged" (1)
(1) Eur J Endocrinol 2002 Mar;146(3):339-46
The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.
Wickman S, Saukkonen T, Dunkel L.
"The concentrations of 17beta-oestradiol, IGF-I and IGF-binding protein-3 increased during testosterone-plus-placebo treatment, but during testosterone-plus-letrozole treatment the concentrations remained unchanged" (1)
(1) Eur J Endocrinol 2002 Mar;146(3):339-46
The role of sex steroids in the regulation of insulin sensitivity and serum lipid concentrations during male puberty: a prospective study with a P450-aromatase inhibitor.
Wickman S, Saukkonen T, Dunkel L.