Hey guys, for all of you that have tried oral and injectible winstrol, is there really that big of a difference. Lets say I take 50mg a day of oral compared to 50mg injectible, would I need to take lets say 75mg orals comparable to 50mg injectibles, since the liver lessens the value.
Winstrol Users!!!!!!
- Thread starter kacoe
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StoneColdNTO
Administrator
Got this off of Brock Strasser's column on T - Mag
Q: There's this huge debate raging over whether or not you can "drink" your Winny-V. I know that because stanozolol is 17-AA'ed, I can use it orally. However, how much more or less effective is oral stanozolol over injected stanozolol? I hear that you need about twice as much stanozolol orally as you would injected to see similar results. How was this figure of doubling the dose orally determined?
A: There isn't a lot of great pharmacokinetic data in humans comparing oral to parenteral (injectable) stanozolol. So that idea of "if you use X amount by injection you need twice as much orally" is anecdotal and speculative at best. The best I could find is a study comparing the two methods of administration in dogs. My comments come after the abstract:
The effect of stanozolol on 15-nitrogen retention in the dog
Can J Vet Res 2000 Oct;64(4):246-8 (ISSN: 0830-9000)
Olson ME; Morck DW; Quinn KB [Find other articles with these Authors] Animal Health Unit and Gastrointestinal Sciences, University of Calgary, Alberta.
The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined.
Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.
Okay, so the oral dose was 28mg/week and the injected dose was 25mg/week. And the injected dose was far better at increasing nitrogen retention (67.0% versus 50.3%). This makes it about 33.2% better (roughly speaking), so if I extrapolate, it means to see the same effects as 25mg of injected stanozolol per week, you'd need to take about 38mg of it orally.
This isn't quite "twice the injected dose" and is, in fact, closer to 50% (52% or so actually). So if you assume the dog model is correct, or nearly so in other mammals like humans, you'd need about 50% more stanozolol orally than you would if you injected it. So if you used 50mg of injected Winstrol every other day, it would be a safe bet to assume 37.5mg of stanozolol used orally every day would provide a similar effect.
__________________
Q: There's this huge debate raging over whether or not you can "drink" your Winny-V. I know that because stanozolol is 17-AA'ed, I can use it orally. However, how much more or less effective is oral stanozolol over injected stanozolol? I hear that you need about twice as much stanozolol orally as you would injected to see similar results. How was this figure of doubling the dose orally determined?
A: There isn't a lot of great pharmacokinetic data in humans comparing oral to parenteral (injectable) stanozolol. So that idea of "if you use X amount by injection you need twice as much orally" is anecdotal and speculative at best. The best I could find is a study comparing the two methods of administration in dogs. My comments come after the abstract:
The effect of stanozolol on 15-nitrogen retention in the dog
Can J Vet Res 2000 Oct;64(4):246-8 (ISSN: 0830-9000)
Olson ME; Morck DW; Quinn KB [Find other articles with these Authors] Animal Health Unit and Gastrointestinal Sciences, University of Calgary, Alberta.
The objective of the study was to determine the influence of either oral or intramuscular administration of stanozolol on nitrogen retention in dogs by using a non-invasive 15N-amino acid tracer technique. Ten healthy, intact, adult male sled dogs received either stanozolol tablets, 2 mg/dog PO, q12h, for 25 days (Group 1, n = 5) or an intramuscular injection of 25 mg of stanozolol on Days 7, 14, 21, and 28 (Group 2, n = 5). A 15N amino acid (5.27 mmol) was infused intravenously into each dog on Day 0 (before stanozolol treatment) and on Day 31 (after stanozolol treatment). Urine was collected by catheterization from each animal 3 times daily for 3 consecutive days. The 15N-urea enrichment in urine was determined by high-resolution mass spectrometry and the total amount of urea in the urine was determined.
Both oral and injectable stanozolol resulted in significant (P < 0.05) increases in amino acid nitrogen retention compared to pretreatment values. Oral stanozolol increased nitrogen retention from 29.2 +/- 8.2% to 50.3 +/- 9.2%, while stanozolol injection increased nitrogen retention from 26.6 +/- 9.9% to 67.0 +/- 7.5%. The response to intramuscular administration was significantly greater than the response to the oral dosing regime. Stanozolol increases amino acid nitrogen retention in dogs, as has been previously observed in rats. This action of stanozolol may be beneficial in dogs under stress of surgical trauma and chronic disease.
Okay, so the oral dose was 28mg/week and the injected dose was 25mg/week. And the injected dose was far better at increasing nitrogen retention (67.0% versus 50.3%). This makes it about 33.2% better (roughly speaking), so if I extrapolate, it means to see the same effects as 25mg of injected stanozolol per week, you'd need to take about 38mg of it orally.
This isn't quite "twice the injected dose" and is, in fact, closer to 50% (52% or so actually). So if you assume the dog model is correct, or nearly so in other mammals like humans, you'd need about 50% more stanozolol orally than you would if you injected it. So if you used 50mg of injected Winstrol every other day, it would be a safe bet to assume 37.5mg of stanozolol used orally every day would provide a similar effect.
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bleachcola
New member
That doesn't make sense. If you "need about 50% more stanozolol orally than you would if you injected it" then why would they recommend you take a smaller amount of Winstrol (winny) orally (37.5mg) to get an equivalent dose of injected Winstrol (winny) (50mg)? Or am I just reading this wrong?
I think what they are saying is that if you take 50mg orals then 37.5mg is actually activated after it passes through your liver. Since Winstrol injectible has no ester, it is straight 50mg or something really close to it. Thanks Stone cold, your post helped me figure most of my oral vs. inject issues.
StoneColdNTO
Administrator
bleachcola said:
Yes, you are reading it wrong.
So if you used 50mg of injected Winstrol every other day, it would be a safe bet to assume 37.5mg of stanozolol used orally every day would provide a similar effect.
bleachcola
New member
StoneColdNTO said:
Ah, that explains it. I just assumed that real men shot Winstrol (winny) on a daily basis.
bleachcola
New member
Mulligan said:
Perhaps that is why I asked for clarification. In the meantime, go hang yourself for being a little immature faggot. My two year old nephew can structure better criticism than you.
jarbulldog
bulldog god
but this goes to the question of wheter you should split the doses of oral Winstrol (winny) throught out the day or just take it all once. Because in dbol I can not tell a difference.
Beast_19_301
Mc deal meal special
so i can inject winstrol eod at 70mg....good to know i didn't wanna inject ed. Just started it right now actually also with some clen
bleachcola
New member
Mulligan said:Oh Shit, you did not understand something. HOLY FUCKIN SHIT
Yeah, there are plenty of things I can't understand. Like why a man your age who works out can't bench 315.
