Adding a methyl group to a steroid

[Clamp]

Step 3: You must conduct the reaction in an inert gas/air free environment. Grignard reagents are extremely sensitive moisture. You must use tetrahydrofuran (diethyl ether may be problematic as it can be used to make other illegal products that LE is more inclined to follow). I wouldn't go the Grignard route. An Sn2 reaction after proper preparation would likely give a lower yield, but it would be an easier home brew. It would require less know how and more readily available reagents. Grignard can be explosive. So, ATF alert there.

Step 4: Removal of a protecting group with commercially available products typically ends with shitty yields. The best chemists get 75%. Most protecting groups can be eliminated via acids or oxidation (which you cant use for this prep)

I am not trying to be an ass. I know I may have come off that way, but stereospecific addition of CH3 is difficult for a home brew. Plus, you wouldn't know what you had unless you knew everything about the finished product--melting points, solubility, and a hundred other things. You would need to use IR spectroscopy or an NMR to determine for sure.

It is such a dangerous compound, and getting to the point of having a dangerous compound could be hazardous as well...physically, and legally. I am not trying to be your dad, but I don't see the value in it. Not that your values are mine, but while it is doable, is it worth it? There wont be a trumpet and cloud splitting sunlight shining on the finished product--it will just be some residue that you won't likely know its constituency.

I cannot help any further, but wish you the best of luck.

Thanks for the help. I can figure out the end product as I have access to some pretty neat lab equipment and all the specifics on it are online and easily findable. I can run chromatography to sort everything out after I've brewed it up as well. Solvents shouldn't be an issue either as I have free access to whatever I need (so long as I give a decent explanation).

I'm doing this more out of the fact that I can, or think I can, than price or necessity. I am not going to be using a large amount of it and tbh I'm not worried about the law as I am already breaking it just by using steroids. Also, steroid laws are based on quantity possessed and as
I'll only be converting a few grams I'd have more legal problems if they found my homebrew test sitting in the other room. Thanks for worrying about me but Ill be fine. Once again, thanks for your help.

 

[joliver]

Thanks for the help. I can figure out the end product as I have access to some pretty neat lab equipment and all the specifics on it are online and easily findable. I can run chromatography to sort everything out after I've brewed it up as well. Solvents shouldn't be an issue either as I have free access to whatever I need (so long as I give a decent explanation).

I'm doing this more out of the fact that I can, or think I can, than price or necessity. I am not going to be using a large amount of it and tbh I'm not worried about the law as I am already breaking it just by using steroids. Also, steroid laws are based on quantity possessed and as
I'll only be converting a few grams I'd have more legal problems if they found my homebrew test sitting in the other room. Thanks for worrying about me but Ill be fine. Once again, thanks for your help.

You know, I like that logic. Doing it because you want to know you can. Admirable. Best answer for the "why" in this case....

 

[Clamp]

Exactly. You never know what you can accomplish until you try.

 

[kataklysum]

I hear ya. It's definitely not cheap. Hopefully someone can answer your question.