Anyone got experience with IGF1-LR3 ?
- Thread starter Trust_
- Start date
Toshiro
New member
Dosage usually goes from 25mcg - 100mcg is considered typical. I had run it at 25mcg every day for a little over a month. Pinned sub-q also. Some do IM but worked fine for me this way.
It helped at that low dose with some soft tissue healing / slight strength increase / very minor muscle increase. I didn't have much sides at all. Maybe some slight bloat, but I'm sensitive to even just a little bit of salt.
I also made sure I ate steadily all day to keep the blood sugar even since LR3 is long acting. Half life 24hours I think. I think at 25mcg a 1mg vial will last for the whole cycle. Hope this helps!
Take care,
T.
It helped at that low dose with some soft tissue healing / slight strength increase / very minor muscle increase. I didn't have much sides at all. Maybe some slight bloat, but I'm sensitive to even just a little bit of salt.
I also made sure I ate steadily all day to keep the blood sugar even since LR3 is long acting. Half life 24hours I think. I think at 25mcg a 1mg vial will last for the whole cycle. Hope this helps!
Take care,
T.
Trust_
New member
Thank you Toshiro!
I will try 50 mcg/d and see how it goes.
Should post workout injections be preferred or it dont mater.?
What should i expect from the igf1-lr3?
Should igf1-lr3 be taking during cycle? Any interaction with HGH? Just curious as how gear, hgh, igf1-lr3 inter relates with each other. Any synergetic effects?
thanks guys
I will try 50 mcg/d and see how it goes.
Should post workout injections be preferred or it dont mater.?
What should i expect from the igf1-lr3?
Should igf1-lr3 be taking during cycle? Any interaction with HGH? Just curious as how gear, hgh, igf1-lr3 inter relates with each other. Any synergetic effects?
thanks guys
Kazmir
New member
Igf1 is best used in conjunction with gear, as well as with HGH. When we inject HGH the major benefit in growth is the release of IGF that hgh promotes. Now using gear, igf, hgh you are maximizing the effects needed for muscular growth and hyperplasia. For best results you are going to want to run it 80-100mcgs per day post workout shot bilaterally into the muscle group you just trained. Meaning if you trained biceps you would shoot 40mcgs into each bi post workout. Basically into the muscle group you are looking for the most growth if you train 2 different muscles in a session. It is normally ran in cycles of 20 -30 days with equivalent time off.
That's way people I know use it at least.
That's way people I know use it at least.
Southernfish
New member
Trust, whats happenin man?!
Ive run two cycles if IGF LR3, I did 50 days on, 50 off, 50 back on again. Both times i was on cycle, Test and other compounds.
The first of the two cycles I ran 60mcg and injected IM bi laterally post workout in the muscle group i had just trained. The second cycle was 100mcg injected IM immediately upon wakening followed immediately by BCAAs then right into breakfast. The later of which i did provided FAR better results, with less side effects, the first run i had really bad nausea and was extremely tired (common side effects). The pumps in the gym were like nothing Ive ever felt, almost unbearable, veins popping out everywhere, and pump would last the majority of the day. I noticed much harder fuller muscles, and a much better mind muscle connection in the gym.
Theres no set in stone rule of injection time, its kind of a see what works best for you type thing, so maybe try a few different things out. You only need one injection per day with LR3 as it has an active life of 30hrs.
Ive run two cycles if IGF LR3, I did 50 days on, 50 off, 50 back on again. Both times i was on cycle, Test and other compounds.
The first of the two cycles I ran 60mcg and injected IM bi laterally post workout in the muscle group i had just trained. The second cycle was 100mcg injected IM immediately upon wakening followed immediately by BCAAs then right into breakfast. The later of which i did provided FAR better results, with less side effects, the first run i had really bad nausea and was extremely tired (common side effects). The pumps in the gym were like nothing Ive ever felt, almost unbearable, veins popping out everywhere, and pump would last the majority of the day. I noticed much harder fuller muscles, and a much better mind muscle connection in the gym.
Theres no set in stone rule of injection time, its kind of a see what works best for you type thing, so maybe try a few different things out. You only need one injection per day with LR3 as it has an active life of 30hrs.
Last edited:
Toshiro
New member
50mcg is a good start. May want to stat lower just to see how you react to it. Since LR3 is long acting I personally don't think it matters when you take it as long as it is consistent. I would venture to guess you may get some minor healing from it. That may help boost your strength a little. For me it was like overhead press was 352 and went up maybe 20-30lbs. So it helps some for my goals of strength ... did that yield super amazing results for muscle mass or anything like that ... uhh no. LOL
I used it with no AAS and had good results. Just FYI on that part. From my limited understanding IGF is what comes out of your body making HGH. So I used GHRP/GHRP + IGF it sort of is like saying 2+2 should = 4 but by taking IGF direct it WILL = 4 no doubt. Basically not giving your body a chance to make IGF on it's own. Think of clomid to boost test vs just taking test. If I'm wrong someone please correct me.
Not sure what it would do with HGH. Probably be ok and the same as other GH inducing peptides. Just keep in mind to eat carbs steadily since IGF can mess with blood sugar. For me being a strength kind of guy I eat all the time and stomach is never empty so it wasn't a problem.
Therealkozmo
Mr. Micropenis
How did it go trust? I am interested in running this compound on my pet gorilla
cybrsage
New member
I found this info about IGF:
TL;DR
IGF does not help build bigger muscles in adults. Its only effects are to increase the rate of healing and to reduce glucose in the bloodstream.
Snippets from a much longer and more in depth explaination:
What purpose, then, does IGF1 serve?
Obviously it serves many purposes. I would not presume to definitively answer this question. However, it does appear clear from experimental data that the proliferative role of IGF1 is limited to developmental growth and to regenerative repair. IGF1 is necessary for proper development and repair following injury. Young, developing mammals not only need IGF1 for proper development, but overexpression leads to increased growth. The same does not happen in adults overexpressing IGF1. From a transgenic study published in 2010: ***8220;In conclusion, these data show that adult non-growing skeletal muscles are refractory to hypertrophy in response to the elevated IGF-1. By contrast, growing muscles respond by activating signalling downstream from the IGF-1 receptor (demonstrated by phosphorylation of Akt, p70S6K) to increase protein accretion by the myofibres. Thus, the IGF-1-mediated hypertrophy evident in adult transgenic muscles results from enhanced increase in muscle mass mainly during the postnatal growth phase.***8221; (ref)
Am I wasting my time and money on IGF1?
Yes. Anecdotes are not scientific evidence, no matter how loudly they are proclaimed. The previously accepted theory on the role of IGF1 in muscle hypertrophy has been reversed. Many are apparently slow to get the message. This should not come as a surprise to readers of this forum. I merely wanted to give a concise review of some of the recent, relevant literature. All currently available scientific evidence based on in vivo studies indicates that IGF1 plays no role in normal, exercise-induced muscle hypertrophy.
I believe that a lot of the observed results is simply a matter of dosing. I'll provide two ways of looking at this:
1) If you understand the reference ranges for physiologic IGF-1, and then you look at the expected volume of distribution of IGF-1, you can come up with a reasonable lower limit for whole body IGF-1 for a single replacement dosage. (Remember that IGF-1 has a relatively short half-life).
Labcorp reference range for IGF-1: Peaks at 15yo (127-554), and for a 36-40yo (83-233)
This frames things a little better. Reference ranges are given in ng/mL. How many mL do you have? A lower limit to the volume of distribution for an adult male would be about 5L. it's probably higher than this because charged particles also get carried by binding proteins (IGFBP3 and albumin for example). Remember your blood volume is lower than your whole body water volume, so this should give us a very overly-conservative lower floor for volume of distribution. 5L is 5000. Multiply that by 233 ng/mL and you would get a replacement dosage to get yourself to the upper limit of normal for a 36-40 year old adult male. This would have to be dosed multiple times a day given the short half life. 233 ng * 5000 mL = 1165000 ng whole body IGF-1. This is equal to approximately 1.2 mg.
So to create a notable physiologic effect, you would likely have to dose IGF-1 at multiple daily doses of at least 1.2mg.
2) Here's the second way of looking at it: Look at the reference range for the 15 year old. It's roughly 2-3 times higher than the adult example I provided. Now, let's look at therapeutic IGF-1 which is prescribed for GH deficiency. The pharmaceutical used is Increlex, which is just recombinant human IGF-1. No adult dosing information is provided, because it is not indicated for adults. Pediatric dosing for > 2years old is 0.04 - 0.12 mg/kg subcutaneously twice daily. A maximum of 0.24 mg/kg is suggested. (Note that these are milligrams, not micrograms). A 100kg bodybuilder would be taking 4 mg twice a day to be at the lower limit of therapeutic for a child. Looking at the reference ranges given above, this is probably not an overestimate of what an adult would need to change his or her physiology to a level that would be noticeable.
3) Here is a human study worth checking out where they gave adult diabetics GH and IGF-1 simultaneously. The administered 0.45 IU and 0.9 IU of GH, and coadministered 15 and 30 micrograms per kilogram per day IGF-1. The higher dose is equivalent to 3000 ug or 3mg per day for a 100kg man.
Their conclusion using lean bodymass, bodyfat, and subcutaneous fat as markers?
Combined GH and IGF-I treatment resulted in positive but rather small effects and might be a treatment option in a few selected patients.
My conclusion is that even 3mg per day of IGF-1 will likely not have significant effects. You would likely need to administer 20+ mg of IGF-1 to get a supraphysiologic effect, and would also likely gain the most benefit if it were combined with GH. Do a quick cost benefit analysis on this one and you might reach the same conclusion that I have.
The best we might be able to do affordably with IGF-1 is get some localized effects such as healing.
Datbtrue
TL;DR
IGF does not help build bigger muscles in adults. Its only effects are to increase the rate of healing and to reduce glucose in the bloodstream.
Snippets from a much longer and more in depth explaination:
What purpose, then, does IGF1 serve?
Obviously it serves many purposes. I would not presume to definitively answer this question. However, it does appear clear from experimental data that the proliferative role of IGF1 is limited to developmental growth and to regenerative repair. IGF1 is necessary for proper development and repair following injury. Young, developing mammals not only need IGF1 for proper development, but overexpression leads to increased growth. The same does not happen in adults overexpressing IGF1. From a transgenic study published in 2010: ***8220;In conclusion, these data show that adult non-growing skeletal muscles are refractory to hypertrophy in response to the elevated IGF-1. By contrast, growing muscles respond by activating signalling downstream from the IGF-1 receptor (demonstrated by phosphorylation of Akt, p70S6K) to increase protein accretion by the myofibres. Thus, the IGF-1-mediated hypertrophy evident in adult transgenic muscles results from enhanced increase in muscle mass mainly during the postnatal growth phase.***8221; (ref)
Am I wasting my time and money on IGF1?
Yes. Anecdotes are not scientific evidence, no matter how loudly they are proclaimed. The previously accepted theory on the role of IGF1 in muscle hypertrophy has been reversed. Many are apparently slow to get the message. This should not come as a surprise to readers of this forum. I merely wanted to give a concise review of some of the recent, relevant literature. All currently available scientific evidence based on in vivo studies indicates that IGF1 plays no role in normal, exercise-induced muscle hypertrophy.
I believe that a lot of the observed results is simply a matter of dosing. I'll provide two ways of looking at this:
1) If you understand the reference ranges for physiologic IGF-1, and then you look at the expected volume of distribution of IGF-1, you can come up with a reasonable lower limit for whole body IGF-1 for a single replacement dosage. (Remember that IGF-1 has a relatively short half-life).
Labcorp reference range for IGF-1: Peaks at 15yo (127-554), and for a 36-40yo (83-233)
This frames things a little better. Reference ranges are given in ng/mL. How many mL do you have? A lower limit to the volume of distribution for an adult male would be about 5L. it's probably higher than this because charged particles also get carried by binding proteins (IGFBP3 and albumin for example). Remember your blood volume is lower than your whole body water volume, so this should give us a very overly-conservative lower floor for volume of distribution. 5L is 5000. Multiply that by 233 ng/mL and you would get a replacement dosage to get yourself to the upper limit of normal for a 36-40 year old adult male. This would have to be dosed multiple times a day given the short half life. 233 ng * 5000 mL = 1165000 ng whole body IGF-1. This is equal to approximately 1.2 mg.
So to create a notable physiologic effect, you would likely have to dose IGF-1 at multiple daily doses of at least 1.2mg.
2) Here's the second way of looking at it: Look at the reference range for the 15 year old. It's roughly 2-3 times higher than the adult example I provided. Now, let's look at therapeutic IGF-1 which is prescribed for GH deficiency. The pharmaceutical used is Increlex, which is just recombinant human IGF-1. No adult dosing information is provided, because it is not indicated for adults. Pediatric dosing for > 2years old is 0.04 - 0.12 mg/kg subcutaneously twice daily. A maximum of 0.24 mg/kg is suggested. (Note that these are milligrams, not micrograms). A 100kg bodybuilder would be taking 4 mg twice a day to be at the lower limit of therapeutic for a child. Looking at the reference ranges given above, this is probably not an overestimate of what an adult would need to change his or her physiology to a level that would be noticeable.
3) Here is a human study worth checking out where they gave adult diabetics GH and IGF-1 simultaneously. The administered 0.45 IU and 0.9 IU of GH, and coadministered 15 and 30 micrograms per kilogram per day IGF-1. The higher dose is equivalent to 3000 ug or 3mg per day for a 100kg man.
Their conclusion using lean bodymass, bodyfat, and subcutaneous fat as markers?
Combined GH and IGF-I treatment resulted in positive but rather small effects and might be a treatment option in a few selected patients.
My conclusion is that even 3mg per day of IGF-1 will likely not have significant effects. You would likely need to administer 20+ mg of IGF-1 to get a supraphysiologic effect, and would also likely gain the most benefit if it were combined with GH. Do a quick cost benefit analysis on this one and you might reach the same conclusion that I have.
The best we might be able to do affordably with IGF-1 is get some localized effects such as healing.
Datbtrue
Southernfish
New member
Interesting, although I don't buy all of what is said in that article. Why are they talking about IGF increasing hypertrophy when in fact like JIMI has stated it increases hyperplastic (the growth of new muscle cells, and even other cells as well)? That's why when taken, just like GH (remember gains from GH are due to increased levels of IGF), for extended periods of time there have been cases, as well, we can all see its happened to many bodybuilders, where joints, bones, organs, and of course muscles have grown to an abnormal size. Especially the intestines, because this is where most of the IGF receptors are located, thus causing the distended stomach.
Another thing, is it seems they are throwing all inj. IGF into the same category. IGF1DES DOES have a short active life, but what about LR3, this IGF has an active life of 30hrs which isnt really short enough to need multiple injections per day.
Lastly, It seems as though this article was written based on a opinion, and although we are all entitled to one, I don't thing there is much to run with on this one. I have ran IGFLR3 twice before, I cant speak of DES as I have never run that, but the doses they are talking about are absolutely ridiculous. I have seen tremendous benefits in terms of strength, growth, muscle fullness, and pumps that are so mind blowing its almost hard to take, and they last all day, off of 100mcg inj. IM once per day in the morning
angrycaveman
New member
if it's real it's great. Good pumps. First time I got accused of using roids while using it during pct. But it will give you sun spots which sucks ass. It will give you lean hard muscles.
Southernfish
New member
It will NOT in deffinetly cause sun spot, this is the first time ive ever heard of this. I never had an issue with this. Dont forget side effects from anything vary from person to person. Nothing is written in stone.
angrycaveman
New member
I agree maybe it was just me or the source. But I really did like it.
