nothing personal man, just don't have the time, maybe later today. there are 2 separate studies I'm referring too. i am pretty sure one is by Lipschultz.
I believe this might be the study you are referencing - almost twenty years old.
J Clin Endocrinol Metab. 1985 Nov;61(5):926-32.
Self-priming effect of luteinizing hormone-human chorionic gonadotropin (hCG) upon the biphasic testicular response to exogenous hCG. I. Serum testosterone profile.
Ulloa-Aguirre A, Mendez JP, Diaz-Sánchez V, Altamirano A, Pérez-Palacios G.
Abstract
The present study was conducted to investigate whether the early (2-8 h) testicular response to a single dose of exogenous hCG depends on previous exposure to LH activity. Four different groups of subjects were studied: 1) four normal adult men [Tanner stage-G5 (T-G5)] and one late pubertal subject (T-G4); 2) normal prepubertal (T-G1) and early- and midpubertal boys (T-G2 and T-G3) (n = 4-6 each); 3) five patients with hypogonadotropic hypogonadism (HH); and 4) two patients with the complete form of the androgen insensitivity syndrome. Each subject received an im injection of hCG (40 IU/kg) on day 1 and blood samples were drawn before and 1-8, 24, 48, and 72 h after injection. At 96 h, a second dose of hCG was given (80 IU/kg) and blood samples were obtained at the same times as after the first hCG dose. Serum testosterone (T) was measured by RIA. The first dose of hCG evoked a biphasic response of serum T in groups T-G2 to T-G5 as well as in the two patients with the complete form of the androgen insensitivity syndrome. The early peak was at 2-7 h, whereas the late T peak was at 48-72 h after injection. In T-G1 children and in patients with HH, the early response did not occur [T-G1, from 129 +/- 43 (SEM) to 288 +/- 127 pg/ml (P greater than 0.05); HH, 79 +/- 18 to 107 +/- 12 (P greater than 0.05) pg/ml], and the late peak was attenuated as compared with the pubertal boys. There were not significant differences in the responses of the T-G1 and the HH groups. After the second dose, all groups had biphasic T responses, although they varied in magnitude. These results demonstrate that previous exposure to LH activity is an obligatory prerequisite for the early peak of the hCG-mediated biphasic testicular response, and that a single dose of hCG has a priming effect that is sufficient to ensure a biphasic response to a second dose of hCG given 96 h later.
As I interpret it, after your first shot of hCG , you get a peak within 2-7 hours. Then you get another peak 48-72 hours later from that
same shot. This is where the "biphasic" comes in. So you seem to be saying that it's a waste to inject again anytime before this 72 hour period is up; that you're throwing away your hCG if you do so. This seems to make sense BUT, what is absent here is any data to disprove the fact that if you DO inject again before that time, there could be FURTHER stimulus to the testes and a
greater spike in T production. Further, the second bump in this study was a weaker one in all cases. There are many things at play that do not necessarily contradict each other and which offers no proof that multiple doses of hCG per week would not be beneficial.
I'll try to find if Lipschultz has anything else to say about this.
*By the way, this study came in the way of help from another forum.
Based on what I see here, I don't think was a good idea to make such a blanket statement above without providing all the facts. Opinions are fine but unless they are stated as such, they can be terribly misleading.
