Aromatase Inhibitors...Arimidex, Aromasin, Letrozole, which one really has least SE's

[sufan8911]

Hey guys,

Looking for experience with any of these ones above, currently on arimidex doc had me at 1mg a day (started off at .25 eod and then ed, doc doesent seem to think anything less than 1mg a day will lower my high levels) but even with smallest dosing Ive had nothing but INTENSE joint pain especially the knee I had problems with in past, and lower back. Also fatigue even tho I take it at night... I had/have low t, when I started this whole process I had 250 total t (250-1100) and an abysmal free t, coupled with estrogen of 100. I took clomid and then tamoxifen, estrogen went up to about 140..then 170 lol, and total t is staying around 420-460. Estrogen is supressing my t levels, Im 23, was never fat until my t took a nosedive a few years back so am now chubby and developing gyno (and just in general feel like ass) Looks like an Aromatase inhibitor (AI) is the best for me... but arimidex just sucked...Ive heard aromasin even tho steroidal has less effect on joints? Letrozole? Sorry for post I know there are prob other posts like this but Ive been searching internet for weeks looking for answers and noone can speak to joint pain / fatigue/ a little bit of depression. Any thoughts? Thanks. BTW all other BW is good, t4, t3, tsh, cortisol a little high but that is because of another medicine. Also have somewhat low LH and FSH.

 

[SolomonGrundy]

wrong section but ok

So right now you're crushed, almost no estrogen so your joints hurt back off to .5 EOD or .25 ED

so you dont take test shot ?

 

[JimiThing]

^^ Yes tell us your protocol if there is one besides just Aromatase inhibitor (AI) therapy....

 

[sufan8911]

sorry about the wrong section and thanks for reply, no not on test, had me on some for a while but it killed my lh fsh and he didnt want to do HCG so i had to get off of it, since im young he wants to try to kickstart my system naturally (clomid or tamoxifen, an AI), I was thinking my estrogen crashed as well, but I had these probs shortly after starting off with .25 eod, and theres no way with my estrogen being as high as it was that .25 eod lowered it that much in a few days... right? that was my thinking idk

 

[sufan8911]

was on testim, but off of that, now just taking Arimidex and took clomid for a couple weeks and then tamoxifen for a couple weeks, so that raised my estrogen to real high (170) but even before that I was sitting at around 100. Doc wants me at 1mg day of arimidex but even lower doses i can barely jog or run with my knee hurting so bad. Been trying glucosamine for joints but that does nothing

 

[SolomonGrundy]

get a new doc, your estrogen is probable under 20 easy right now. cut back , clomid should increase Test production

 

[sufan8911]

you think it can be under 20 even at .25 ed or eod? yeah clomid and tamoxifen seemed to have been doing the job in raising test but the high estrogen i think is keeping it from being as high as it can be, if I decide to go a diff route from arimidex..i heard aromasin was the next best? espec on joints, I heard letrozole had most SE's and was worse than arimidex with joint pain ? was thinking of a new doc as well lol, thanks

 

[JimiThing]

Well Aromasin will be more difficult to crash e2 levels on for sure, however blood work is really required to dial this in properly. Im not against a switch to stane as long as you can monitor where you are with proper blood work. I would definitely seek different medical attention than you current are under however.

 

[sufan8911]

yeah I usually get pretty regular blood work, I think I may try aromasin just cause even on lower doses arimidex killed me lol, it seems to me like the top two are arimidex and aromasin...letrozole seems to be the odd man out? And do you agree with me that lowering my estrogen with an Aromatase inhibitor (AI) while taking a serm like clomid will prob fix my low t? i had a good trial run with clomid so thats what Im thinking

 

[SolomonGrundy]

i did blood this week, 500 mg test E2 was 35, thats 12.5 mg aromasin daily , might add a second nightly dose the day after injections to get it to 20

 

[sufan8911]

and no SE's with the 12.5 a day of aromasin? my most recent bw was total estrogen 176, total t 488 (250-1100), free t 115.7 (35-155) estriadol (e2??) was 42. doc also seems to think my high E is throwing TSH and prolactin a little out of whack (because whenever my e is lower around 90-100 my tsh and prolactin are perfect, whenever its crazy high, my tsh and prolactin also rise, guess everythings connected)