Still swimming in breast cancer results on Google but found this for letro.
"""Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the
cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in
all tissues. Treatment of women with letrozole significantly lowers serum estrone, estradiol
and estrone sulfate and has not been shown to significantly affect adrenal corticosteroid
synthesis, aldosterone synthesis, or synthesis of thyroid hormones.
Letrozole is rapidly and completely absorbed from the gastrointestinal tract and absorption is
not affected by food. It is metabolized slowly to an inactive metabolite whose glucuronide
conjugate is excreted renally, representing the major clearance pathway. About 90% of
radiolabeled letrozole is recovered in urine. Letrozole***8217;s terminal elimination half-life is about
2 days and steady-state plasma concentration after daily 2.5 mg dosing is reached in 2-6
weeks. Plasma concentrations at steady state are 1.5 to 2 times higher than predicted from the
concentrations measured after a single dose, indicating a slight non-linearity in the
pharmacokinetics of letrozole upon daily administration of 2.5 mg. These steady-state levels
are maintained over extended periods, however, and continuous accumulation of letrozole
does not occur. Letrozole is weakly protein bound and has a large volume of distribution
(approximately 1.9 L/kg)."""
the link goes straight to a pdf so I didnt copy and paste it. It's a .gov so should be legit info.
My medications elevate P450 enzymes so its action in
good read on letrozole thanks for sharing!