I have done a lot or reading on B12 and I have found it is given to anemics for vitamin B12 deficiency, Chronic fatigue syndrome (CFS) but I have not read any reason for its use in anabolics. So my question is why people take it on cycle what’s the reason, benefit, are there any of you that have taken? I think this is a misunderstood drug and needs to be made clear….any input, articles, anything?
B12 benefits
- Thread starter jenergy
- Start date
nekronom
New member
It gives me a great pump. Taking the amps for injection (3000mg) twice a week the first two weeks, then once a week for some weeks. I always felt a great pump. And there are no sides. But I prefer it after a cycle, when you feel that you "miss" something, then B12, crea, sometimes ephe. But I am intersted in reading the pro-advices, too.
StoneColdNTO
Administrator
Unless you are B12 deficient, it has to be the most over-rated supplement out there.
jarbulldog
bulldog god
i agree with stonecold that it is completely overrated. i do though take 1500mcg of b-12 twice a day but i take caps and hjave read that the difference between cap and injectrion is almost none
latinking24
New member
ok first off caps are useless...your body cant digest and use B12 in pill form..you lose 90% of it...it has to be injected...and at least 1,000mcgs a day...i dont know what nephrom is talking about but please nobody listen to him it is complete ignorance....you cant take just 1000 mcgs and expect it to do anything...it takes at least a month of straight use for you to notice anything...you cant take over 1000mcgs a day because you will just piss it out.....allot of people will see nothing at all from b12..some will see awsome energy appetite and immunity functions....it really depends on the person....
StoneColdNTO
Administrator
latinking24 said:
Sorry but this study tends to disagree with you, and I certainly and strongly disagree with your dosing of at least 1000mcg/day. If you are going to take injectable b12, I'd suggest 1000mcg EOD for the first two weeks, then 1000mcg very week or two after that.
Clin Ther. 2003 Dec;25(12):3124-34.
Oral versus intramuscular cobalamin treatment in megaloblastic anemia: a single-center, prospective, randomized, open-label study.
Bolaman Z, Kadikoylu G, Yukselen V, Yavasoglu I, Barutca S, Senturk T.
Department of Internal Medicine, Division of Hematology, Adnan Menderes University Medical School, Aydin, Turkey. zahitb@yahoo.com
BACKGROUND: Cobalamin (vitamin B12) deficiency, the most common cause of megaloblastic anemia, is treated with intramuscular (IM) cobalamin. It has been suggested by some investigators that oral (p.o.) cobalamin treatment may be as effective in the treatment of this condition, with the advantages of ease of administration and lower cost. OBJECTIVE: This study assessed the effects and cost of p.o. versus i.m. cobalamin treatment in patients with megaloblastic anemia due to cobalamin deficiency. METHODS: This was a 90-day, prospective, randomized, open-label study conducted at the Division of Hematology, Department of Internal Medicine, Adnan Menderes University Research and Practice Hospital (Aydin, Turkey). Patients aged > or =16 years with megaloblastic anemia due to cobalamin deficiency were randomized to receive 1000-microg cobalamin p.o. once daily for 10 days (p.o. group) or 1000-microg cobalamin i.m. once daily for 10 days (i.m. group). After 10 days, both treatments were administered once a week for 4 weeks, and after that, once a month for life. Patients were assessed for the presence of reticulocytosis between treatment days 5 and 10 until it was detected. Therapeutic effectiveness was assessed by measuring hematologic parameters on days 0, 10, 30, and 90 and serum vitamin B12 concentration on days 0 and 90. The Mini-Mental State Examination was used before and after the B12 therapy for cognitive function assessment and 125-Hz diapozone was used for vibration threshold testing. Neurologic sensory assessment, including soft-touch and pinprick examinations, was used to identify neuropathy at baseline and study end. Tolerability was assessed using laboratory tests and patient interview. Cost was assessed using the cost of the study drug and of the injection. RESULTS: Sixty patients completed the study 26 in the p.o. group (16 men, 10 women; mean [SD] age, 60 [15] years) and 34 in the i.m. group (17 men, 17 women; mean [SD] age, 64 [10] years). Reticulocytosis was observed in all patients. In the p.o. group, at days 30 and 90, all hematologic parameters changed significantly versus day 0 (mean hemoglobin levels increased [both P<0.001]; mean corpuscular volume decreased [both P<0.001]; mean white blood cell count increased [day 30, P<0.01; day 90, P<0.001]; and mean platelet count increased [both P<0.001]). The mean serum vitamin B12 concentration increased significantly from day 0 to 90 (P<0.001). These hematologic parameters and the recovery patterns were similar between the 2 groups. Neurologic findings included sensitive peripheral neuropathy in 9 patients (15.0%), alteration of cognitive function (loss of memory, impaired concentration) in 7 patients (11.7%), and loss of sense of vibration in 5 patients (8.3%). Neurologic improvement was detected in 7 of 9 patients (77.8%) in the p.o. group and 9 of 12 patients (75.0%) in the i.m. group at day 30. CONCLUSIONS: In this study of patients with megaloblastic anemia due to cobalamin deficiency, p.o. cobalamin treatment was as effective as i.m. cobalamin treatment. P.o. treatment also was better tolerated and less expensive compared with IM treatment. However, because of the small sample size and the short term of this study, further long-term studies are needed to determine the efficacy of p.o. cobalamin treatment.
StoneColdNTO
Administrator
jenergy said:
Correct......
latinking24
New member
i dont care what the study says...from personal experience i think a competitive athlete needs it every day for it to be effective....this random dosing may work for regular people...
StoneColdNTO
Administrator
latinking24 said:
Did you even bother to read the study, cause it had nothing to do with dosing schedule, it was about comparing Oral versus intramuscular B12 use.
jarbulldog
bulldog god
so basiccally stonecold you are saying that the results from oral and injection are about the same?
