BROMOCRIPTINE: Why has it lost its appeal?

[macro]

progesterone is essential for healthy sex drive. Deca effects on libido are due to the fact that it suppresses natural progesterone and its affect at the receptor is significantly different.

Progesterone= good
progestins= more often than not BAD.


Bromo's sides are harsh because of its ratio of D receptor affinity, and why people prefer cabergoline

selegiline is quite effective and neuroprotective as well (mao-b metabolites of dopamine are neurotoxic)

 

[Drveejay11]

selegiline is quite effective and neuroprotective as well (mao-b metabolites of dopamine are neurotoxic)

Sure would have been NICE to have this stuff around when I partied in college


Administered at low doses, selegiline is neuroprotective against possible damage to the serotonergic fine axon terminals caused by overconsumption of the popular drug MDMA (Ecstasy). Several competing theories exist to explain MDMA-induced neurotoxicity. One theory blames the deamination by MAO-B of excessive dopamine taken up by the membrane-bound transporter into the depleted serotonin terminals. This abnormal uptake follows MDMA-induced reversal of the serotonin reuptake pump. In the absence of MAO-B inhibition, deamination by MAO-B of excess dopamine taken up into the serotonergic axon terminals is liable to generate a glut of toxic free radicals. These highly reactive compounds cause membrane lipid peroxidation and consequent fine terminal degeneration. Selegiline prevents such serotonergic damage, in theory at any rate.




NOW you tell me!!!

LOL

 

[franmidi]

Great postings in this thread! I know it's against posting rules, but when such things as TMG are so well documented and discussed, it would be very helpful if some supported links could be introduced to find the product.

I try looking through Google and other search engines before posting, but when those searches come up empty, where else can someone turn for information other than "people in the know" that seem to make up this board?

Thanks!

 

[Drveejay11]

Great postings in this thread! I know it's against posting rules, but when such things as TMG are so well documented and discussed, it would be very helpful if some supported links could be introduced to find the product.

I try looking through Google and other search engines before posting, but when those searches come up empty, where else can someone turn for information other than "people in the know" that seem to make up this board?

Thanks!

By the way: TMG is an over-the-counter LEGAL supplement and NOT an AS. I was a lil confused by your post so I just wanted to clarify that in the event you were confused.

 

[Nelson Montana]

Great postings in this thread! I know it's against posting rules, but when such things as TMG are so well documented and discussed, it would be very helpful if some supported links could be introduced to find the product.

I try looking through Google and other search engines before posting, but when those searches come up empty, where else can someone turn for information other than "people in the know" that seem to make up this board?

Thanks!

TMG is legal but but readily available but you can get it from vitaminshoppe.com It's also part of the SHBG lowering supplement "Unleashed" from protein factory . com

 

[Drveejay11]

TMG is legal but but readily available but you can get it from vitaminshoppe.com It's also part of the SHBG lowering supplement "Unleashed" from protein factory . com

SHAMELESS

 

[Roger]

Bromo versus Dostinex:

Firstly I am not a bodybuilder... just in bed with flu and bored.. so reading up on all sorts of stuff and since the xxx section is down.. had a look at the other stuff in this forum..
I have used both Dostinx and Bromocyptine but for the real reason namely that my Prolactin was slighlty on the high side. .. Done several tests always the same. (unless I do a brain scan they can't explain why...)

Both lower Prolactin. So now since my prolactin was too high and Bromo defn. made me honier-- like in immediately the next morning ..also when I took double the prescibed does I could orgasm 3 times in a row and felt like 18 again. (I was 30 at the time)

Only .. and other have also mentioned this .. after a few weeks .. it stops working.. o.k. the Prolactin level are still low but I could not orgasm more or better than before.

Dostinex works less impressive but the effect stays longer.. I also tend to gain a bit of strength when on Dostinex...Now for most guys who's Prolactin is already normal.. no idea..how it will change it.. but better orgasms were reported for bromo...

What is TMG and SAM-e? Have there been studies on it?
I am interested since I still take Dostinex and although I have found a cheaper source from Swizerland.. it is still relatively expensive.

 

[R1pilot]

Great info on the TMG, but what if you are willing to spend the little extra cash and go with the SAM-e? What would be a good dosage?

 

[putin]

Wasn't aware of B-6 lowering Prolactin. Hmm....interesting.

Here's the TMG info Tex:

The benefits of TMG (Tri-methyl-glycine)
Note Sunnie contains TMG!

Betaine TMG (not to be confused with Betaine HCL) works along with Vitamin B6, folic acid and Vitamin B12 to augment the formation of SAMe, an amino acid in the brain. Amino acids are proteins.

What are some of the benefits of TMG?

TMG (Betaine Anhydrous) is a methyl donor with the following applications in human nutrition:

Anti-depression: By raising level of beneficial SAM (S-Adenosyl-Methionine).

Dose range: 500-1,500 mg daily

Body building: In the animal husbandry field, TMG is used to decrease fat and increase meat yield. While human studies have just started, a 200 pound individual with 20% body fat can expect to lose as much as 5 pounds of fat and gain as much as 12 pounds of muscle.

Dose range: 500-2,000 mg daily

Cardiac protection: Conversion of homocysteine to Methionine.

Dose range: 500-1,000 mg daily

General Health Preventative: As part of a formula for maintaining good health or disease prevention.

Dose range: 500-1,000 mg daily

Glutathione Elevation: In several different studies, TMG has been shown to increase hepatic Glutathione, the body's most important antioxidant.

Dose range: 500-1,500 mg daily

Homocysteine Lowering: Specific for that purpose. The supplement of choice for lowering homocystenuria,

Dose range: 500-1,000 mg daily.
As used by clinicians and hospitals with patient monitoring -up to 3 grams daily

Liver Disorders: As a part of liver-healing and protection formulas. Increases SAM levels in the liver, enables the liver to metabolize fat and protect against many challenges such as alcohol induced cirrhosis. TMG will also decrease bilirubin, alkaline phosphotase, and several other liver enzymes related to a large variety of liver disorders. Significant liver benefits have been shown in 20 studies.

Dose range: 500-1,500 mg. daily.

Longevity Formulations: As a part of a life extension formula. TMG has shown ability to protect interrogate of cellular DNA through methyl donation.

Dose range: 500-1,000 mg daily.

Methyl Donor Formulations: Along with B12, Folic acid, and Choline.

Dose range: 500-1,500 mg. daily.

Performance: Due to it's bi-polar nature, helps osmotic pressure in cells. For example it is used in salmon farming to protect fish against the problems of changing salt content. In humans, TMG maintains normal cellular electrolyte concentrations despite water and electrolyte losses during exercise. TMG also helps metabolize fats, which allows the body to burn fat rather than protein or muscle during exercise. The result is less cramping, increased endurance, and better utilization of fat stores,

Dose range: 1,000-2,000 mg daily.

Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans.

Olthof MR, van Vliet T, Verhoef P, Zock PL, Katan MB.

Wageningen Centre for Food Sciences, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands. margreet.olthof@wur.nl

BACKGROUND: Betaine (trimethylglycine) lowers plasma homocysteine, a possible risk factor for cardiovascular disease. However, studies in renal patients and in obese individuals who are on a weight-loss diet suggest that betaine supplementation raises blood cholesterol; data in healthy individuals are lacking. Such an effect on cholesterol would counteract any favourable effect on homocysteine. We therefore investigated the effect of betaine, of its precursor choline in the form of phosphatidylcholine, and of the classical homocysteine-lowering vitamin folic acid on blood lipid concentrations in healthy humans. METHODS AND FINDINGS: We measured blood lipids in four placebo-controlled, randomised intervention studies that examined the effect of betaine (three studies, n = 151), folic acid (two studies, n = 75), and phosphatidylcholine (one study, n = 26) on plasma homocysteine concentrations. We combined blood lipid data from the individual studies and calculated a weighted mean change in blood lipid concentrations relative to placebo. Betaine supplementation (6 g/d) for 6 wk increased blood LDL cholesterol concentrations by 0.36 mmol/l (95% confidence interval: 0.25-0.46), and triacylglycerol concentrations by 0.14 mmol/l (0.04-0.23) relative to placebo. The ratio of total to HDL cholesterol increased by 0.23 (0.14-0.32). Concentrations of HDL cholesterol were not affected. Doses of betaine lower than 6 g/d also raised LDL cholesterol, but these changes were not statistically significant. Further, the effect of betaine on LDL cholesterol was already evident after 2 wk of intervention. Phosphatidylcholine supplementation (providing approximately 2.6 g/d of choline) for 2 wk increased triacylglycerol concentrations by 0.14 mmol/l (0.06-0.21), but did not affect cholesterol concentrations. Folic acid supplementation (0.8 mg/d) had no effect on lipid concentrations. CONCLUSIONS: Betaine supplementation increased blood LDL cholesterol and triacylglycerol concentrations in healthy humans, which agrees with the limited previous data. The adverse effects on blood lipids may undo the potential benefits for cardiovascular health of betaine supplementation through homocysteine lowering. In our study phosphatidylcholine supplementation slightly increased triacylglycerol concentrations in healthy humans. Previous studies of phosphatidylcholine and blood lipids showed no clear effect. Thus the effect of phosphatidylcholine supplementation on blood lipids remains inconclusive, but is probably not large. Folic acid supplementation does not seem to affect blood lipids and therefore remains the preferred treatment for lowering of blood homocysteine concentrations.


I would say the risk outweighs the benefit.

 

[trailrider]

Thanks all for this info, but it leaves me with several questions, one being, what are the side effects of bromo that everyone keeps mentioning?

 

[Razorsharp]

Not sure if this bit of info has been mentioned but Bromo also does an outstanding job of RAISING leptin levels. THis is crucial when on a cutting diet and cravings are an issue.