Megatron28
Moderator
Also, from what I understand, aromasin is the only ai you can take effectively with nolvadex. Arimidex and nolvadex have contraindications and subsequently lower the blood levels of one or the other making one or the other less effective. Vets-please chime in on this as I'm nearly certain I read that in a previous thread.
You can go online and look up drug interactions.
Interactions between your selected drugs
tamoxifen and; anastrozole
Applies to: tamoxifen, Arimidex (anastrozole)
GENERALLY AVOID: Coadministration with tamoxifen may decrease the plasma concentrations of anastrozole. The mechanism of interaction has not been described. In one clinical trial, coadministration of tamoxifen (20 mg/day) and anastrozole (1 mg/day) in breast cancer patients resulted in decreased anastrozole plasma concentration by 27% compared to administration of anastrozole alone. In addition, at a median follow-up of 33 months, the combination did not demonstrate any efficacy benefit over tamoxifen therapy alone in all patients as well as in the hormone receptor-positive subpopulation, and this treatment arm was discontinued from the trial. The pharmacokinetics of tamoxifen and its pharmacologically active N-desmethyl metabolite were not affected.
MANAGEMENT: Concomitant use of tamoxifen and anastrozole should be avoided.