DIM vs Arimidex while on TRT

[tlow2013]

Does DIM help stop the downgrading of androgen receptors the way Arimidex does?

 

[IMT staff]

DIM helps you get rid of more estrogen, it does not slow the conversion of T to E like an Aromatase inhibitor (AI) would.

 

[tlow2013]

But by getting rid of it does that stop it from binding to the receptors?

 

[halfwit]

But by getting rid of it does that stop it from binding to the receptors?

From what I understand DIM flushes out the excess "free-floating" estrogens in your blood stream, which can bind to your androgen receptors. If you're aromatizing a great deal; that only helps the symptoms, not the problem itself. I can see using both if you're sitting with higher estradiol levels, but I don't believe DIM has any effect on SHBG, nor as mentioned above can it prevent this aromatization from taking place. I honestly know relatively few facts about receptor downregulation/desensitization/overloading as there are many conflicting studies on the subject.

 

[JimiThing]

I dont think "downgrading"or "downregulation"are the proper terms to explain what really happens. There really is no such phenomenon as in the presence of excess androgens the life span of AR's increases and so does the production of new AR's - so it does not occur. DIM helps the body metabolize estrogen Id suspect by somehow impacting the cyp enzyme/s responsible for the metabolism of removal of e2. Ai's reduce aromatase lowering the aromitiztion of test to estrogen. By using an Aromatase inhibitor (AI) there will be less estrogen present, by using DIM the estrogen present will be metabolized or removed more quickly/efficiently. One thing you have to wonder is since the same cyp enzymes responsible for the metabolism of estrogen are also responsible for the metabolism of testosterone is tha is there a corresponding reduction in test as well or is that even of any clinical significance given you are supplementing with exogenous testosterone. Dont know if that helps at all .... lol

 

[tlow2013]

Thanks for the responses, I'm going to give it a shot for a couple weeks and see if my high E2 symptoms disappear. My Endo will not give me an Aromatase inhibitor (AI) so I figured this might be a good start to trying to feel better on TRT. My SHBG is on the low side too so if DIM doesn't impact it that will make it a more attractive alternative instead of an Aromatase inhibitor (AI). If my insurance covers Human Chorionic Gonadotropin (HCG) I'm switching to it temporarily to try to determine if I'm primary or secondary but I will be going back on T after about 2 months as long as the Human Chorionic Gonadotropin (HCG) gets my levels up if not I will be back on T within a couple of weeks.

 

[tlow2013]

I guess the question to ask then is does DIM cut down on estradiol binding to the androgen receptors by getting it out of your system faster?