Does post cycle therapy (pct) really work? Yes it does!

Millertime

Millertime

Dedication=Respect
Does pct really work? Yes it does!

Guys I have been on and off for years but the older I get I'm looking to do things right. I get blood and test checked every year. 3 yrs ago I was at 347 total test, last year I was 274 total. This is with a lazy half ass pct. So the dr prescribed hrt. I blasted and cruized for another year then decided to really do a proper pct. Did the exact protocal to a T. Waited 12 full weeks from my last hit of test prop. Again I have been using for years then on for a entire year. Went and got things checked and my total test was 471! I'm amazed and kinda happy because I'm looking to have kids within the next few years and didn't want any issues that could come with hrt. So guys my advice to you is get tested regularly, don't be a cheap ass and not buy the right gear for pct.
 
I started pct 3 days after my last test prop shot. Then did the pct protocal for a total of six weeks. Then got my testosterone checked 6 weeks after I stopped my clomid and nolvadex. Total time after my last test shot was 12 weeks before my bloodwork.
 
Also like to give a shout out to rui. First time using them and the gear is legit. Appreciate it guys...
 
dayhawk said:
12 weeks??

I started at week 3...because I heard you shut down at week 5 if you don't PCT...I'm confused
Click to expand...
you shut down on cycle. thats not somethign you avoid, thats somethign you accept. then you do PCT to help speed up recovery after cycle. PCT during cycle is pointless...
 
juced_porkchop said:
you shut down on cycle. thats not somethign you avoid, thats somethign you accept. then you do PCT to help speed up recovery after cycle. PCT during cycle is pointless...
Click to expand...

Thinking about this from a pharmacological point of view, since clomiphene is a antagonist on the hypothalamus, and since the whole process of negative feedback is controlled by estrogen levels, isn't it theoretically possible that we could keep our HPGA running by keeping our estrogen at physiological levels and by administrating clomiphene during AAS use?

The only issue I can see is that clomiphene acts as a antagonist at Estrogen Receptor Beta (found in the breast and hypothalamus), but its action at Estrogen Receptor Alpha (bone, uterus) varies between agonist/antagonist depending on estradiol concentration. Technically this action would be beneficial, decreasing negative feedback at the hypothalamus, while exerting positive effects on bone mineral density. In a perfect world of course.

Now imagine if we could find a inverse agonist (which reverses the effect on the receptor, not just blocking it) that specifically bound to Estrogen Receptor Beta..... You could theoretically increase your natural production of testosterone without exogenous administration, and/or even keep this increase in natural production during exogenous "blasting" of AAS.

But anyways, has anyone tried/heard/seen studies of clomiphene use during cycle that prevented or helped prevent shutdown?
 
bushleaguechew said:
Thinking about this from a pharmacological point of view, since clomiphene is a antagonist on the hypothalamus, and since the whole process of negative feedback is controlled by estrogen levels, isn't it theoretically possible that we could keep our HPGA running by keeping our estrogen at physiological levels and by administrating clomiphene during AAS use?

The only issue I can see is that clomiphene acts as a antagonist at Estrogen Receptor Beta (found in the breast and hypothalamus), but its action at Estrogen Receptor Alpha (bone, uterus) varies between agonist/antagonist depending on estradiol concentration. Technically this action would be beneficial, decreasing negative feedback at the hypothalamus, while exerting positive effects on bone mineral density. In a perfect world of course.

Now imagine if we could find a inverse agonist (which reverses the effect on the receptor, not just blocking it) that specifically bound to Estrogen Receptor Beta..... You could theoretically increase your natural production of testosterone without exogenous administration, and/or even keep this increase in natural production during exogenous "blasting" of AAS.

But anyways, has anyone tried/heard/seen studies of clomiphene use during cycle that prevented or helped prevent shutdown?
Click to expand...

Activation of the cellular receptors from exogenous steroids will overpower any type of antagonistic signal from clomid.
 
DreDay187 said:
Activation of the cellular receptors from exogenous steroids will overpower any type of antagonistic signal from clomid.
Click to expand...

AAS do not activate the negative feedback receptors at the hypothalamus, estrogen does.

Edit. There is one antagonist which down regulates receptors, Faslodex, however I'm not sure which receptor it works on. Also it would not be cost effective, nor easily obtainable.
 
Last edited:
bushleaguechew said:
AAS do not activate the negative feedback receptors at the hypothalamus, estrogen does.

Edit. There is one antagonist which down regulates receptors, Faslodex, however I'm not sure which receptor it works on. Also it would not be cost effective, nor easily obtainable.
Click to expand...

AAs may not affect the negative feedback loop but the HPTA is a dynamic feedback loop system. There's more to it than just the negative feedback portion. The hypothalamus and pituitary can recognize androgens and control their production. Excess estrogenic activity is one of the negative feedback loops and so is excess progestagenic activity.

Negative feedback to the pituitary and hypothalamus is critical to maintain endocrine homeostasis in the male. Testosterone is the main testicular steroid, but significant aromatase activity in the testicle and peripheral tissues results in production of estradiol as well. Testosterone clearly inhibits kisspeptin transcription and GnRH and gonadotropin secretion. Some of this inhibition is estrogen independent, but estradiol seems to play an important role in steroid negative feedback in the male, particularly by decreasing LH production.
Click to expand...
 
DreDay187 said:
AAs may not affect the negative feedback loop but the HPTA is a dynamic feedback loop system. There's more to it than just the negative feedback portion. The hypothalamus and pituitary can recognize androgens and control their production. Excess estrogenic activity is one of the negative feedback loops and so is excess progestagenic activity.
Click to expand...

Mehhhhh :cockblock


Mark my words I will create a cocktail that will prevent shutdown...... eventually......... hopefully.......
 
308power said:
Hey, I like the thought process brother. The body is just too smart :/.
Click to expand...

Too many pathways all doing the same, yet different process. Theres 20+ different drug classes used to lower blood pressure, all with different effects, side effects, and degrees of success.
 
what did you do for PCT?
clomid and nolva

im in the same boat want to have kiddies in the near future off everything right now... want to get on HGH so hard to fine
 
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