Dosing Letrozole - Need help understanding

[wise]

Hi, I have a few questions about Letrozole:

* I read that the drug can take up to 6 weeks to stabilize and take effect in the body - is this true?

* I also read that 2.5mg everyday is too high of a dose, and some say take it every other day or 2-3 times per week. Others say take 1mg per day, and variations like that. What is the proper dose to ensure the drug is dosed enough to work?

* Leading from that question, one article claimed that there is a minimum dosage necessary for the drug to activate (I think they said 2mg dose minimum or it won't work) is this true or not?

I want to become comfortable with my knowledge of this drug so I know what I'm doing when I use it.

Thanks guys, I appreciate it!

 

[kataklysum]

First things first. Never take 2.5mg of letro per day. That's crazy. Lots of people hate letro. It's only because they dose it so high. It's strong stuff. My max dose is 0.5mg E3D. If I go any higher then that my estrogen is non existent and It feels like I have razor blades in my knees because of dry joints. I normally dose it around 0.25mg E3D

If I was you and it's your first time. Start off with 0.1mg (100mcg) E3D and up your dose as needed. You may think that dose is too small to do anything but you'd be suprised. Everyone is different so I can't tell you how your going to react but personally i never exceed 0.5mg E3D.

 

[Southernfish]

I dont really see a need, in my opinion, for Letro unless preparing for a show. It murders estrogen to an u healthy level and it can cause quite the rebound effect once you come off. It does however work very nice for drying you out giving your muscles a nice dry look. It also, depending on dose can kill sex drive, ive been on 1G of test and started running letro at .25mgEOD and my sex drive and ability to get hard was 0. If you are interested though id do kataklysum suggested start low and increase as you see fit, or as your bloodwork dictates

 

[wise]

Thanks guys. Is it better to take 0.25mg E3D or split it up into .08mg ED (same dose) - basically it comes down to how long it takes to release and stabilize in the blood.

Does it take long time to get in/out of the system?

Also, can you minimize the rebound effect by gradually tapering off of it? I think it's good for Test cycles to prevent gyno, I'd rather prevent it than battle against it later.

 

[kataklysum]

i wouldnt worry about ED dosing. the half life is 48 hours. i find e3d works fine. if i pin on monday and thursday i take my letro dose on monday and thursday. this way your peak letro levels coincide with your slight hormone spike on the day of injection.

after my last pin i still take letro e3d but ill drop from .25mg to .1mg and run that till i start pct. then the clomid and torem starts so that takes care of any rebound effect that "might" happen. ive never had an issue doing it this way.

 

[justin h]

I normally go .05 mon/wed/fri
One time (first time) I used 2.5 for 3days then 2.0/3days..1.5/3days ect, to get rid of some gyno. It got rid of gyno with the quickness as well as my libido. Dried my joints, lost alot of water weight, which was the only plus..
Anyway...yeah .5 is plenty..although for a test only cycle I'd get a less "harsh" form of an AI. Aromasin/adex will do fine for test only cycles.

 

[wise]

Great info guys, thanks a ton!
A few more questions if that's okay:

1) At about what does does it start to kill libido?
2) At about what does does it dry up the joints?
3) How much water weight did you lose with Letro and at what dose?

 

[kataklysum]

For me 0.5mg or higher e3d is when the joints go.

Start low and you won't have any trouble. Starting off with 0.1mg e3d seems like its too low of a dose but it will still pack a punch. Then just up your dose as needed.

 

[justin h]

Great info guys, thanks a ton!
A few more questions if that's okay:

1) At about what does does it start to kill libido?
2) At about what does does it dry up the joints?
3) How much water weight did you lose with Letro and at what dose?

Since I started at the max, it shot my libido. Dried joints/lost water.
I've never dealt with a libido crash like that before.
But once I was at 1.25 libido came back, everythinv kinda got back go normal. Now I know theirs no need for such a high dose. If and only if you have gyno and neglected it, is when you want to up the dose. But preventive dose should only be .5-.25 at most

 

[juced_porkchop]

Hi, I have a few questions about Letrozole:

* I read that the drug can take up to 6 weeks to stabilize and take effect in the body - is this true?

* I also read that 2.5mg everyday is too high of a dose, and some say take it every other day or 2-3 times per week. Others say take 1mg per day, and variations like that. What is the proper dose to ensure the drug is dosed enough to work?

* Leading from that question, one article claimed that there is a minimum dosage necessary for the drug to activate (I think they said 2mg dose minimum or it won't work) is this true or not?

I want to become comfortable with my knowledge of this drug so I know what I'm doing when I use it.

Thanks guys, I appreciate it!

2.5mg is way too much per dose.

i rec 0.25--1.2mg eod-e3d.

 

[juced_porkchop]

0.25-0.6mg eod- e3d i rec to start with. you have to see how it works for you and on what cycles what dose works best IMO

 

[wise]

I appreciate the responses everyone.
I guess what I need to know now is how can I tell if I need to change the dose? How long should I wait to see what happens before deciding to change the dose?

Also how do you know if a dose is too low?
How do you know if a dose is too high? (symptoms)

That should cover everything I need. Thanks!!