Fat burning and Anavar

JohnnyB

JohnnyB

Community Veteran
I thought I'd put this up, for us more seasoned;) Bros

Posted by kkramer at Bolex

Anavar seems to be great for fat loss, but is not exactly something i would call "safe":

Int J Obes Relat Metab Disord 1995 Sep;19(9):614-24

Oral anabolic steroid treatment, but not parenteral androgen treatment, decreases abdominal fat in obese, older men.

Lovejoy JC, Bray GA, Greeson CS, Klemperer M, Morris J, Partington C, Tulley R.

Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124, USA.

OBJECTIVE: To compare the effects of testosterone enanthate (TE), anabolic steroid (AS) or placebo (PL) on regional fat distribution and health risk factors in obese middle-aged men undergoing weight loss by dietary means.

DESIGN: Randomized, double-blind, placebo-controlled clinical trial, carried out for 9 months with primary assessments at 3 month intervals. Due to adverse blood lipid changes, the AS group was switched from oral oxandrolone (ASOX) to parenteral nandrolone decaoate (ASND) after the 3 month assessment point. SUBJECTS: Thirty healthy, obese men, aged 40-60 years, with serum testosterone (T) levels in the low-normal range (2-5 ng/mL).

MAIN OUTCOME MEASURES: Abdominal fat distribution and thigh muscle volume by CT scan, body composition by dual energy X-ray absorptiometry (DEXA), insulin sensitivity by the Minimal Model method, blood lipids, blood chemistry, blood pressure, thyroid hormones and urological parameters.

RESULTS: After 3 months, there was a significantly greater decrease in subcutaneous (SQ) abdominal fat in the ASOX group compared to the TE and PL groups although body weight changes did not differ by treatment group. There was also a tendency for the ASOX group to exhibit greater losses in visceral fat, and the absolute level of visceral fat in this group was significantly lower at 3 months than in the TE and PL groups. There were significant main effects of treatment at 3 months on serum T and free T (increased in the TE group and decreased in the ASOX group) and on thyroid hormone parameters (T4 and T3 resin uptake significantly decreased in the ASOX group compared with the other two groups). There was a significant decrease in HDL-C, and increase in LDL-C in the ASOX group, which led to their being switched to the parenteral nandrolone decanoate (ASND) after 3 months. ASND had opposite effects on visceral fat from ASOX, producing a significant increase from 3 to 9 months while continuing to decrease SQ abdominal fat. ASND treatment also decreased thigh muscle area, while ASOX treatment increased high muscle. ASND reversed the effects of ASOX on lipoproteins and thyroid hormones. The previously reported effect of T to decrease visceral fat was not observed, in fact, visceral fat in the TE group increased slightly from 3 to 9 months, although SQ fat continued to decrease. Neither TE nor AS treatment resulted in any change in urologic parameters.

CONCLUSIONS: Oral oxandrolone decreased SQ abdominal fat more than TE or weight loss alone and also tended to produce favorable changes in visceral fat. TE and ASND injections given every 2 weeks had similar effects to weight loss alone on regional body fat. Most of the beneficial effects observed on metabolic and cardiovascular risk factors were due to weight loss per se. These results suggest that SQ and visceral abdominal fat can be independently modulated by androgens and that at least some anabolic steroids are capable of influencing abdominal fat.

JohnnyB
 
Here's 2 studies that might help, the second one is with a high protein diet.

Short-term oxandrolone administration stimulates net muscle protein synthesis in young men.

Sheffield-Moore M, Urban RJ, Wolf SE, Jiang J, Catlin DH, Herndon DN, Wolfe RR, Ferrando AA.

Department of Surgery, University of Texas Medical Branch, and Shriners Burn Hospital for Children, Galveston 77550, USA. melmoore@utmb.edu

Short term administration of testosterone stimulates net protein synthesis in healthy men. We investigated whether oxandrolone [Oxandrin (OX)], a synthetic analog of testosterone, would improve net muscle protein synthesis and transport of amino acids across the leg. Six healthy men [22+/-1 (+/-SE) yr] were studied in the postabsorptive state before and after 5 days of oral OX (15 mg/day). Muscle protein synthesis and breakdown were determined by a three-compartment model using stable isotopic data obtained from femoral arterio-venous sampling and muscle biopsy. The precursor-product method was used to determine muscle protein fractional synthetic rates. Fractional breakdown rates were also directly calculated. Total messenger ribonucleic acid (mRNA) concentrations of skeletal muscle insulin-like growth factor I and androgen receptor (AR) were determined using RT-PCR. Model-derived muscle protein synthesis increased from 53.5+/-3 to 68.3+/-5 (mean+/-SE) nmol/min.100 mL/leg (P < 0.05), whereas protein breakdown was unchanged. Inward transport of amino acids remained unchanged with OX, whereas outward transport decreased (P < 0.05). The fractional synthetic rate increased 44% (P < 0.05) after OX administration, with no change in fractional breakdown rate. Therefore, the net balance between synthesis and breakdown became more positive with both methodologies (P < 0.05) and was not different from zero. Further, RT-PCR showed that OX administration significantly increased mRNA concentrations of skeletal muscle AR without changing insulin-like growth factor I mRNA concentrations. We conclude that short term OX administration stimulated an increase in skeletal muscle protein synthesis and improved intracellular reutilization of amino acids. The mechanism for this stimulation may be related to an OX-induced increase in AR expression in skeletal muscle.

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Combined effects of hyperaminoacidemia and oxandrolone on skeletal muscle protein synthesis.

Sheffield-Moore M, Wolfe RR, Gore DC, Wolf SE, Ferrer DM, Ferrando AA.

Department of Surgery, University of Texas Medical Branch, Galveston 77550, USA. melmoore@utmb.edu

We investigated whether the normal anabolic effects of acute hyperaminoacidemia were maintained after 5 days of oxandrolone (Oxandrin, Ox)-induced anabolism. Five healthy men [22 +/- 3 (SD) yr] were studied before and after 5 days of oral Ox (15 mg/day). In each study, a 5-h basal period was followed by a 3-h primed-continuous infusion of a commercial amino acid mixture (10% Travasol). Stable isotopic data from blood and muscle sampling were analyzed using a three-compartment model to calculate muscle protein synthesis and breakdown. Model-derived muscle protein synthesis increased after amino acid infusion in both the control [basal control (BC) vs. control + amino acids (C+AA); P < 0.001] and Ox study [basal Ox (BOx) vs. Ox + amino acids (Ox+AA); P < 0.01], whereas protein breakdown was unchanged. Fractional synthetic rates of muscle protein increased 94% (BC vs. C+AA; P = 0.01) and 53% (BOx vs. Ox+AA; P < 0.01), respectively. We conclude that the normal anabolic effects of acute hyperaminoacidemia are maintained in skeletal muscle undergoing oxandrolone-induced anabolism.

JohnnyB
 
Treatment with Oxandrolone and the Durability of Effects in Older Men.

Schroeder ET, Zheng L, Yarasheski KE, Qian D, Stewart Y, Flores C, Martinez C, Terk M, Sattler FR.

Division of Infectious Diseases, University of Southern California, Keck School of Medicine, Los Angeles, CA, USA; Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, CA, USA.

We investigated the effects of the anabolic androgen, oxandrolone, on lean body mass (LBM), muscle size, fat, and maximum voluntary muscle strength, and determined the durability of effects after stopping treatment. Thirty-two healthy 60-87 year old men were randomized to receive 20 mg oxandrolone/day (n = 20) or placebo (n = 12) for 12 weeks. Body composition (DEXA, MRI and D2O dilution) and muscle strength (1-repetition maximum; 1-RM) were evaluated at baseline and after 12 weeks of treatment; body composition (DEXA) and 1-RM strength were then assessed 12 week after discontinuing treatment (week 24). At week 12, oxandrolone increased LBM 3.0+/-1.5kg (P<0.001), total body water 2.9+/-3.7kg (P=0.002), proximal thigh muscle area 12.4+/-8.4cm(2) (P<0.001); these increases were greater (P<0.003) than in the placebo group. Oxandrolone increased 1-RM strength for leg press 6.7+/-6.4% (P<0.001), leg flexion 7.0+/-7.8% (P<0.001), chest press 9.3+/-6.7% (P<0.001), and latissimus pull-down 5.1+/-9.1% (P=0.02) exercises; these increases were greater than placebo. Oxandrolone reduced total (-1.9+/-1.0kg) and trunk fat (-1.3 +/-0.6kg; P<0.001) and these decreases were greater (P<0.001) than placebo. Twelve weeks after discontinuing oxandrolone (week 24), the increments in LBM and muscle strength were no longer different from baseline (P>0.15). However, the decreases in total and trunk fat were sustained (-1.5+/-1.8, P=0.001 and -1.0+/-1.1kg, P<0.001, respectively). Thus, oxandrolone induced short-term improvements in lean body mass, muscle area, and strength, while reducing whole-body and trunk adiposity. Anabolic improvements were lost 12 weeks after discontinuing oxandrolone, while improvements in fat mass were largely sustained.

JohnnyB
 
Although Anavar would put a dent in anyones wallet, it is one of the safest Orals analogous to the more affordable Winstrol, especially since British Dragon came out with a 50mg Winstrol pill recently.

Anavar is one of the safer drugs which is regularly given to children whose growth is stunted among other common problems...or problems such as lack of lean muscle in men, anemia, muscle breakdown because of strong prescription drugs.

IT IS COMMONLY BELIEVED THAT ANAVAR NEEDS TO BE TAKEN 50MG PLUS, WHICH IS NOT TRUE. AS LITTLE AS .30 PER KG FOR A MALE IS MORE THAN REASONABLE--IF IN DOUBT SPEAK TO A POWERLIFTER OR TWO...THEY USUALLY SWEAR BY THIS ASS ALTHOUGH AT HIGHER DOSAGES. ANYMORE THAN 40MG PER DAY BECOMES TOXIC JUST LIKE THE OTHER ORALS.


...IF I COULD GET MY HANDS IN ON ANY ASS THIS WOULD BE IT---THAT IS ASSUMING A USER ALREADY IS AT LEAST 200LB + AND NOT WORRIED ABOUT PUTTING ON WEIGHT AND ONLY SOME QUALITY MUSLCE. THIS IS EXCELLENT AT PRODUCING LEAN MUSCLE MASS AND STRENGTH THAT LASTS ONCE THE CYCLE IS COMPLETED GIVEN PROPER PCT.

HERE IS SOME MORE INFO:
"Some lean tissue growth over about 15 mg/day. Men need 20-50 mg/day, women 5-20 mg/day. New data presented in 1998 at the Geneva AIDS Conference by Grunfeld showed evidence of potential liver toxicity with doses of 40 or 80 mg per day with HIV(+) subjects, perhaps because it may interact with 3A4 p450 liver enzymes that metabolize protease inhibitors. Watch liver enzymes/GGT. Very gentle at low doses, though, but only weakly anabolic. Very small chance of virilization for women. Used without testosterone may decrease libido. Most effective for muscle growth when used with testosterone"

AS I SAID ABOVE, THOSE NOT WORRIED ABOUT SIZE--DON'T BOTHER WITH TESTOSTERONE FOR MUSCLE GROWTH...YOU DON'T NEED A BASE IT WORKS WELL BY ITSELF
 
yup
did 40 mg a day for 5 months , and the fat loss midsection was incredibale .. i have not been able to afford another cyce and even though my deit and training are relitivly the same , i can not seem to put a real dent in the midsection .. last to go ..
As far as strengh , and cardio vascular endurance , it is again my favorite just for the effect of being able to run that extra 40 k a week :)
peace
hempster
 
Then again, one could do 12-16 weeks of Ox alone, then turn to HGH and not only would fat stay away, but muscle gains would stay.
Both products are expensive, probably the best to take if we are talking about men wanting to stay on the safe side.

Jeff

And it is a good article.
 
hey im thinking about doing a 30mg/day cycle on anavar for 5 weeks, what should i do for post cycle therapy (pct)? ive heard 100mg/day clomid week one and 50mg/day week 2 will be fine, but ive also heard that nolvadex is better and safer, which should i go with? any advice would be appreciated
 
Ive been using 750mg test weekly and 100mg tren daily for about 2 months now.
I used to have a belly that hung out and down quite a bit. I have lost a total of 17 lbs but my lifts have gone up a lot, there is also a heck of a lot of obvious increase in muscle mass

Now my stomach is extremely flat, even if i try to inhale deep and force it to stick out I cant really get it to get much bigger. I thought this was mainly due to an increase in abdominal muscles keeping my stomach in place. Now I wonder if the tren just made a ton of belly fat melt away?
 
these studies really mean nothing to the normal, healthy 18-35 year old crowd. Of course ana Anavar (var) is gonna have a drastic effect on 40+ year old obese men with low testosterone. The reason theyre obese is BECAUSE low testosterone leads to decreased lbm and estrogen levels creep up and cause fat storage. The study probably wouldve had even better results with testosterone. The first thing men notice when they go on testosterone replacement therapy (TRT) is they start slimming up around the midsection.


Id be willing to bet these are the studies that started the whole internet myth about Anavar (var) and fatburning and it is a myth imo.
 
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