First Cycle... start of week 3... possible gyno? :(

Roush said:
Just keep doing what your doing,, don't miss an AI dose, get bloods soon,, and you'll be fine.
And like mega said you can get some raloxifene to use as a Gyno insurance policy..

Do that and stay away from carnivals and you'll be good
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Going to get bloods on Friday. Also going to order some raloxifene. Also going to try & relax. Thank for the advice and laughs dude!
 
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Megatron28 said:
Here is what Wikipedia says on the matter.

There are 2 types of aromatase inhibitors (AIs) approved to treat breast cancer:[1]

Irreversible steroidal inhibitors, such as exemestane (Aromasin), forms a permanent and deactivating bond with the aromatase enzyme.

Non-steroidal inhibitors, such as anastrozole (Arimidex) and letrozole (Femara), inhibit the synthesis of estrogen via reversible competition for the aromatase enzyme.
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could you expand on this? dose this mean that aromasin reduces estrogen forever? by the permanent bond with the aromatase enzyme?
 
Bigboss12 said:
could you expand on this? dose this mean that aromasin reduces estrogen forever? by the permanent bond with the aromatase enzyme?
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Permantly binds yes but you are constantly having the t to e conversion so new estrogen molecules so you constantly have to take the aromasin daily. Make sense?
 
Bigboss12 said:
could you expand on this? dose this mean that aromasin reduces estrogen forever? by the permanent bond with the aromatase enzyme?
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Personally. I think the whole suicidal/non-suicidal AI thing is overrated. Aromatase is constantly being repllaced with new aromatase enzymes. Estradiol has a half life. Old estradiol is constantly being replaced with new estradiol.

But the point of a suicidal AI is that once it attaches to the aromatase receptor it stays there and that enzyme will never convert test into estrogen again. With non-suicidal AI's, it can become detached from the receptor and then the receptor is available to convert test into estrogen again. For as long as it "lives" anyway. Aromatase enzymes have a life span.
 
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Megatron28 said:
Personally. I think the whole suicidal/non-suicidal AI thing is overrated. Estradiol has a half life. Old estradiol is constantly being replaced with new estradiol.

But the point of a suicidal AI is that once it attaches to the aromatase receptor it stays there and that enzyme will never convert test into estrogen again. With non-suicidal AI's, it can become detached from the receptor and then the receptor is available to convert test into estrogen again.
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would this mean that aromisan is the most effective then? I've always used adex and it has worked well for me. i just like learning as much as i can that why this is interesting to me.
 
Bigboss12 said:
would this mean that aromisan is the most effective then? I've always used adex and it has worked well for me. i just like learning as much as i can that why this is interesting to me.
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On paper Aromasin is superior. It usually costs more though and for most guys Arimidex works just fine.

One other thing to consider is that Arimidex is usually harder on the lipids compared to Aromasin.

Aromasin has a shorter half life and should be taken daily. Arimidex has a much longer half life.
 
Megatron28 said:
On paper Aromasin is superior. It usually costs more though and for most guys Arimidex works just fine.

One other thing to consider is that Arimidex is usually harder on the lipids compared to Aromasin.

Aromasin has a shorter half life and should be taken daily. Arimidex has a much longer half life.
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arimidex being harder on lipids is that in relation to cholesterol? I'm sorry for all the questions? i don't know to much on this subject but I'm enjoying this discussion thank you for the replies.
 
Good thread guys! It was very informative finding out the biggest difference between aromasin and adex. Also reinforced my opinion of stane.
 
Bigboss12 said:
Where woul letro fit in?
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Harder to dose, not as much play as you could easily crash e2... Aromisin and arimidex are more forgiving sort to speak,,, but Letro as an AI with Gyno,issues is a fairly common protocol

Also Letro is way cheaper
 
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