I have read about guys that have taken as much as 250 mcgs. per day but I would never do that. My max dose is also 100 mcg. and I take it all at once, first thing in the a.m., on an empty stomach. You can also split the dose, I don't think it matters all that much either way. Although I believe the half life is short enough that there might be some small advantage to splitting the dose, the absorbtion is greatest on an empty stomach so that should be kept in mind.