Good reading
3J shot down IF big time when I brought this up a couple of months ago.
I actually tried IF for a few months. I lost some weight but I also lost some muscle mass and some strength in the gym.
Well the reason why fasting on and shortly after the peptides is because any fat or carb intake will spike insulin. Insulin will blunt GH secretion. So by fasting you will get a much larger spike.
This is true wether someone is on them or not.
FFA supress glucose uptake and oxidation, resulting in muscular insulin resistance, without reducing insulin secretion.
These effects seem to be dependent on dietary carbohydrate restriction.
FFA-induced muscular insulin resistance is a physiological response to low availability of glucose.
Under normal conditions, this serves to maintain adequate BG levels. When FFA are in excess, there might be a rise in BG levels, because oxidation and release of FFA are not coupled. This leads to insulin resistance in other tissues like the liver (15), consequently failing to control hepatic glucose output.
A diet high in fat and low in carbohydrates will reduce glucose metabolism and increase fat metabolism. Conversely, a high carbohydrate-low fat diet increases glucose utilization and decreases fatty acid metabolism.
Increased glucose utilization implies upregulation of glucose membrane transporters and enzymes involved in glycolysis. Additionally, it reduces the activity of enzymes involved in fat metabolism.
Increased fatty acid metabolism inhibits key glycolytic enzymes, as well as GLUT membrane translocation. It also interrupts glucose/insulin signaling and stimulates lipolytic enzymes.
Above is from the same article you referenced.
I failed to see anything about dietary FAT provoking an immediate insulin response. I believe what he was saying is a chronicly high serum FFA's could lead to insulin resistance in muscle tissue as well as the liver.
We know FAT does not turn into glucose as protein can in the liver (gluconeogenisis), and carbs do.. glucolysis, so those will generate a insulin response as when you get a glucose spike, it's insulin's job to keep BG levels at healthy levels. I know from my own glucose testing, hundreds of tests with a glucose meter and testing strips, dietary fat does not increase my BG levels. The article you reference makes some good points however in that, when I eat extremely low carb, insulin is usually very low and therefore, I will wake with higher BG levels than if I have a small amount of glucose before bed and therefore, get an insulin response which helps control the BG. Total calories eaten and energy expenditure also play be huge role in BG levels regardless of macronutrient breakdown. I think the article you referenced did a good job of stating that.
Also if you look at any food insulin index (similar to a food glycemic index), you'll see very few high fat foods make the list as they don't produce a high blood insulin response. Good article. Thanks.
Fineberg et al. showed that GH release by protein ingestion can be inhibited but not completely abolished by increases in postprandial FFA concentrations (14). These studies show that alterations in FFA concentrations also modified GH secretion. Together, all previous mentioned studies show that both plasma glucose and plasma FFA concentrations influence GH secretion. Therefore, the question remains of which macronutrients are most responsible for interference with the protein-induced GH secretion. More research with studies that only add either carbohydrates or fat to the protein being assessed is necessary.
the clinical relevance of the results of this study, however, remains to be investigated. these results show that in normal healthy women, gh responses increase after oral ingestion of proteins, but not when proteins are combined with carbohydrates and fat. it is not known whether this effect also occurs in a gh-deficient population, such as in visceral obese subjects. In the visceral obese subjects, gh replacement therapy reduced weight and in particular decreased fat mass and increased lean body mass (17, 18); moreover it appeared that weight loss also restored gh concentrations to normal values (19). It may be useful to explore the possibility of adding only one other macronutrient to soy protein in order to be able to design a diet that could stimulate gh secretion in such a population.
High-fat food ingestion before exercise blunts the GH response in adults
A high-fat meal before exercise, therefore (a common event in Western societies), may reduce the growth factor response to exercise in children, with potential implications for growth and development.
Since the amount of carbohydrate intake was identical within both diets, these findings are probably related to the differences in dietary fat and/or its energy content. Our findings are consistent with a preliminary report in monozygotic twins, which showed, in clamped energy balance conditions (i.e. standardized overfeeding or negative energy balance for 100 days by food restriction), that ghrelin concentrations tend to decrease and leptin to increase in a condition of energy surfeit (i.e. HF diet), whereas the opposite was observed in a state of energy shortage (i.e. LF diet) (34). Several studies have demonstrated that glucose is essential in modulating leptin levels (22). In addition, data on rat adipocytes suggest that insulin-mediated glucose metabolism, and not insulin per se, is critical in increasing leptin secretion (35). The current findings, however, in contrast to previous studies (23, 36), suggest that dietary fat affects leptin concentrations. Differences in study protocol and study population are probably responsible for the dissimilar results. Information on the effect of macronutrients on ghrelin levels is limited. Our results are consistent with those of Lee et al. (37), who showed ghrelin plasma levels to be significantly lower in rats fed HF diet than in control rats. However, due to the dietary protocol with different percentages of carbohydrates within the HF and LF diets, the respective role of these nutrients in regulating ghrelin secretion could not be determined. In healthy human subjects, however, recent evidence suggests (27) that an acute lipid load results in a significant decrease in ghrelin levels.
The bottom-line is that fasting has shown to increase GH secretion, so it is best to do this while using the peptides, I have used them more times than i can remember. In order to get the best results, or to ensure that you will get the best results, it only makes sense to fast.
Im not saying your wrong at all, I'm just saying its better to be safe than sorry.
yes i agree. in regards to peptide timing, fasting is best.. and that is what we're talking about anyway. i just got caught up on the fact that I read above not to eat carbs or fat around the peptide pin which made me question the insulin response to fat. i know from first hand knowledge and testing that glucose does not elevate when i eat fat (like a teaspoon of olive oil), but even BCAA's, protein and of course any carbs will have an immediate glucose response followed by a insulin response which is what we are trying to avoid. thanks very much for the time and links. very interesting!!