cybrsage
New member
I know we all have heard that HGH is good for tendons and other connective tissues, but how many of us have actually looked at studies to prove it? Lets find out!
I will break down the studies with tidbits and such as I go along.
The tendon study is: Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis and can be found here: Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
1mg is 2.7IUs of HGH. A 200 pound person is about 90kg (yeah, 91, but 90 makes the math easier). Lets use the top end of the range in the study to see the max amount they used in it, which is 50 micrograms/kg per day. This means they used 50 X 90 = 4000 micrograms per day, which is also 4mg. Continuing the math, we find that 4 X 2.7 = 10IUs. If we use the bottom end, 33 micrograms, we find 33 X 90 = 2970 (lets round to 3000). 3000 micrograms is 3 milligrams, so 3 X 2.7 = 8.1IUs. Both are VERY VERY high, so keep that in mind. Anecdotally, lower doses should do the same thing, just to lesser effect.
This basically says that the overall IGF-1 in the body is not important, what is important is the LOCAL IGF-1 level. This supports the view of those who say doing many small injections in the area you want to improve your tendon strength is superior to doing one large injection. It also says that IGF-1 is the source of the improvement, not HGH itself. I think we all already knew that, but it is nice to see it proven.
This one shocked me as it goes directly against Bro-Science. It basically says that, even at 10IUs a day, NO increase in the size and strength of muscle fibers was seen at all. It DOES increase it in animals, but has been proven more than once that it DOES NOT increase it in humans. But since it makes the tendons stronger, you can work harder without feeling pain and therefor the extra work you are doing will increase your muscles.
WOW! Only 14 days of 10IUs caused a 6 times increase, or 600% increase, in collagen synthesis! Anecdotally, if you take 2IUs a day, you can see a doubling of your collagen synthesis. Just wow.
This says if you have injured yourself (which almost always will include tendon damage - just the way we humans tend to break), using a dose HGH regimen WILL reduce your recovery time.
In conclusion, HGH will not cause the growth of your muscles. It WILL strengthen your muscles' supportive matrix (tendons, etc). This will then allow you to push more weight and therefor get stronger.
The first fat reduction study is: Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. It can be found here: Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic bl... - PubMed - NCBI
1mg is 2.7IUs of HGH. A 200 pound person is about 90kg (yeah, 91, but 90 makes the math easier). 9.5 is basically 10, which makes for very easy math. 90 X 10 = 900. 900 micrograms is 0.9 milligrams. 0.9 X 2.7 = 2.43 IUs. That is in the range that most people use, since most people will use from 2IUs to 4IUs per day.
The average fat loss after 9 months of about 2.5IUs of HGH was 9.2%, with belly fat being reduced by 18%!! Overall health was improved as well. The only negative effect was the 2 hour glucose level (GDR). It was harder for the body to remove glucose immediately after its induction, so keep that in mind. After that 2 hour period, the glucose levels were better for those using HGH than those not using it.
And not to leave out the post-menopausal women and fat reduction, here is another study: Growth Hormone Treatment Reduces Abdominal Visceral Fat in Postmenopausal Women with Abdominal Obesity: A 12-Month Placebo-Controlled Trial Found here: http://press.endocrine.org/doi/full/10.1210/jc.2004-1657#sthash.WtSPw6w1.dpuf
The target dose was 2IU a day. A nice low number that most users will be at or above.
HGH is great for reducing cholesteral in women. VAT is visceral adipose tissue, which is the inner belly fat (as opposed to the belly fat found just under the skin). It seems that women will lose the fat on the upper thigh, but not the inner belly fat. Men lose the inner belly fat (and tend to not store fat on the upper thighs anyway, so hard to lose fat that is not there). Sorry ladies, no or very little spot reduction in the belly for you at 2IUs, though you WILL lose fat on the upper thighs. The study does say the results might be different at 4IUs, but they did not test at that level.
The lack of belly fat loss in women was also proven in another study: Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls found here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247194/pdf/13633_2014_Article_359.pdf
It mirrors the first female study, just on a younger group of women (under 18 years but past puberty). So again, sorry ladies, no belly fat reduction for you. Still, it does improve many other things (cholesteral, the look and feel of skin and nails, and a better overall feeling of well being) so do not discount using HGH.
I will break down the studies with tidbits and such as I go along.
The tendon study is: Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis and can be found here: Growth hormone stimulates the collagen synthesis in human tendon and skeletal muscle without affecting myofibrillar protein synthesis
1mg is 2.7IUs of HGH. A 200 pound person is about 90kg (yeah, 91, but 90 makes the math easier). Lets use the top end of the range in the study to see the max amount they used in it, which is 50 micrograms/kg per day. This means they used 50 X 90 = 4000 micrograms per day, which is also 4mg. Continuing the math, we find that 4 X 2.7 = 10IUs. If we use the bottom end, 33 micrograms, we find 33 X 90 = 2970 (lets round to 3000). 3000 micrograms is 3 milligrams, so 3 X 2.7 = 8.1IUs. Both are VERY VERY high, so keep that in mind. Anecdotally, lower doses should do the same thing, just to lesser effect.
This basically says that the overall IGF-1 in the body is not important, what is important is the LOCAL IGF-1 level. This supports the view of those who say doing many small injections in the area you want to improve your tendon strength is superior to doing one large injection. It also says that IGF-1 is the source of the improvement, not HGH itself. I think we all already knew that, but it is nice to see it proven.
This one shocked me as it goes directly against Bro-Science. It basically says that, even at 10IUs a day, NO increase in the size and strength of muscle fibers was seen at all. It DOES increase it in animals, but has been proven more than once that it DOES NOT increase it in humans. But since it makes the tendons stronger, you can work harder without feeling pain and therefor the extra work you are doing will increase your muscles.
WOW! Only 14 days of 10IUs caused a 6 times increase, or 600% increase, in collagen synthesis! Anecdotally, if you take 2IUs a day, you can see a doubling of your collagen synthesis. Just wow.
This says if you have injured yourself (which almost always will include tendon damage - just the way we humans tend to break), using a dose HGH regimen WILL reduce your recovery time.
In conclusion, HGH will not cause the growth of your muscles. It WILL strengthen your muscles' supportive matrix (tendons, etc). This will then allow you to push more weight and therefor get stronger.
The first fat reduction study is: Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic blood pressure. It can be found here: Growth hormone treatment of abdominally obese men reduces abdominal fat mass, improves glucose and lipoprotein metabolism, and reduces diastolic bl... - PubMed - NCBI
1mg is 2.7IUs of HGH. A 200 pound person is about 90kg (yeah, 91, but 90 makes the math easier). 9.5 is basically 10, which makes for very easy math. 90 X 10 = 900. 900 micrograms is 0.9 milligrams. 0.9 X 2.7 = 2.43 IUs. That is in the range that most people use, since most people will use from 2IUs to 4IUs per day.
The average fat loss after 9 months of about 2.5IUs of HGH was 9.2%, with belly fat being reduced by 18%!! Overall health was improved as well. The only negative effect was the 2 hour glucose level (GDR). It was harder for the body to remove glucose immediately after its induction, so keep that in mind. After that 2 hour period, the glucose levels were better for those using HGH than those not using it.
And not to leave out the post-menopausal women and fat reduction, here is another study: Growth Hormone Treatment Reduces Abdominal Visceral Fat in Postmenopausal Women with Abdominal Obesity: A 12-Month Placebo-Controlled Trial Found here: http://press.endocrine.org/doi/full/10.1210/jc.2004-1657#sthash.WtSPw6w1.dpuf
The target dose was 2IU a day. A nice low number that most users will be at or above.
HGH is great for reducing cholesteral in women. VAT is visceral adipose tissue, which is the inner belly fat (as opposed to the belly fat found just under the skin). It seems that women will lose the fat on the upper thigh, but not the inner belly fat. Men lose the inner belly fat (and tend to not store fat on the upper thighs anyway, so hard to lose fat that is not there). Sorry ladies, no or very little spot reduction in the belly for you at 2IUs, though you WILL lose fat on the upper thighs. The study does say the results might be different at 4IUs, but they did not test at that level.
The lack of belly fat loss in women was also proven in another study: Effect of Recombinant Human Growth Hormone (rhGH) on Abdominal Fat and Cardiovascular Risk in Obese Girls found here: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4247194/pdf/13633_2014_Article_359.pdf
It mirrors the first female study, just on a younger group of women (under 18 years but past puberty). So again, sorry ladies, no belly fat reduction for you. Still, it does improve many other things (cholesteral, the look and feel of skin and nails, and a better overall feeling of well being) so do not discount using HGH.
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