Just recently did a restart. Here are the results!

[lakers0812]

On testosterone replacement therapy (TRT) for a a little over a year, now off. These were the results after 3 restart attempts. The first two failed miserably:

total testosterone: 1086

free test: 17 (9.3-26.5)

FSH: 5.1 (1.5-12.4)

LH: 9.6 (1.7-8.6)

Sex hormone binding globulin or shbg: 75.5 HIGH (16.5-55.9) ???

DHEA 242 (31-701)

prolactin: 5.3 (4-15.2)

estradiol: 38.7 (7.6-42.6)


This is what I got after completing a post cycle therapy (pct), after a hcg blast, and waiting 6 weeks to get labs. The first blast i did 500 iu ed for 12 days and 2 months clomid and nolva. It didn't work and I felt like a woman. Next I did a 1000 iu blast for 6 days followed by another 2 month pct and that didn't work either. Finally I did a 1500iu Scally power pct protocol eod for 6 total injections along with 50 mg clomid and 20 mg nolva and aromasin. I continued the pct for another month and finally my testosterone was back to what it used to be before I ever put gear in my body.

Does anybody know why my shbg was so high? Also what are the effects it would have on my hpta (thyroid, testosterone, etc)? Anybody know how to reduct it? I've hear of using some herbs, which I may do soon.

 

[lakers0812]

Recently did a 3rd restart. Here are the results!

On testosterone replacement therapy (TRT) for a a little over a year, now off. These were the results after 3 restart attempts. The first two failed miserably:

total testosterone: 1086

free test: 17 (9.3-26.5)

FSH: 5.1 (1.5-12.4)

LH: 9.6 (1.7-8.6)

Sex hormone binding globulin or shbg: 75.5 HIGH (16.5-55.9) ???

DHEA 242 (31-701)

prolactin: 5.3 (4-15.2)

estradiol: 38.7 (7.6-42.6)


This is what I got after completing a post cycle therapy (pct), after a hcg blast, and waiting 6 weeks to get labs. The first blast i did 500 iu ed for 12 days and 2 months clomid and nolva. It didn't work and I felt like a woman. Next I did a 1000 iu blast for 6 days followed by another 2 month pct and that didn't work either. Finally I did a 1500iu Scally power pct protocol eod for 6 total injections along with 50 mg clomid and 20 mg nolva and aromasin. I continued the pct for another month and finally my testosterone was back to what it used to be before I ever put gear in my body.

Does anybody know why my shbg was so high? Also what are the effects it would have on my hpta (thyroid, testosterone, etc)? Anybody know how to reduct it? I've hear of using some herbs, which I may do soon.

 

[3J]

a very low dosage of aromasin should take care of the shbg... i would say maybe 12.5mg eod...

 

[halfwit]

Whoa. I've never seen someone increase their SHBG like that without estradiol being INSANELY high. Agree with 3J as an Aromatase inhibitor (AI) can most certainly reduce SHBG, but you might be able to wait it out and see if it normalizes. Otherwise, your labs look FANTASTIC!

 

[lakers0812]

Thanks for the reply guys. I think I figured out exactly why my shbg increased. I had a reverse t3 problem so I took t3 only for 12 weeks. At the highest dose I was taking, I was on 125 mcg. Apparently t3 icreases shbg.

I'm very sensitive to aromasin even to the point that I would completely crash my e2 while on trt. I think I'll do 5 mg eod.

 

[Megatron28]

For my education, how does Aromasin decrease SHBG? Would any Aromatase inhibitor (AI) have the same effect? Here is what I found on SHBG.

TESTOSTERONE TRANSPORT IN BLOOD.
Testosterone circulates mainly bound to two plasma proteins, sex hormone–binding globulin (SHBG; also known as testosterone-binding globulin) and albumin. In young adult men, about 54% of testosterone is bound to albumin, 44% is bound to SHBG, and 2 to 3% is unbound or free. The SHBG-testosterone fraction is tightly bound and serves a storage role. Bioavailable testosterone refers to the sum of albumin-bound and free testosterone and is measured by separating SHBG-bound testosterone from the total testosterone in the serum. Serum SHBG levels are increased in endogenous and exogenous hyperestrogenemic states, hyperthyroidism, aging, phenytoin treatment, anorexia nervosa, and prolonged stress. SHBG levels are lowered with androgen treatment, obesity, acromegaly, and hypothyroidism. In most instances, measurement of serum total testosterone will detect individuals with androgen deficiency. In conditions with abnormal SHBG levels, the total testosterone measurement (usual laboratory test requested) may be misleading. In these situations, direct measurement of free testosterone by the dialysis method, measurement of bioavailable testosterone, or calculation of the free testosterone by a formula requiring the serum testosterone and SHBG concentrations may be necessary to separate true chemical testosterone deficiency from binding protein problems. Testosterone secretion has a diurnal variation and is highest in the morning in young adult men; this rhythm is blunted or lost with aging.

 

[halfwit]

Thanks for the reply guys. I think I figured out exactly why my shbg increased. I had a reverse t3 problem so I took t3 only for 12 weeks. At the highest dose I was taking, I was on 125 mcg. Apparently t3 icreases shbg.

I'm very sensitive to aromasin even to the point that I would completely crash my e2 while on trt. I think I'll do 5 mg eod.

I'll be damned. I didn't know T3 could increase SHBG. I knew increased estrogen over extended periods of time could, and that increasing androgens/reducing estrogen is a means of lowering it - very interesting. I think I have some more research to do now.

For my education, how does Aromasin decrease SHBG? Would any Aromatase inhibitor (AI) have the same effect? Here is what I found on SHBG.

TESTOSTERONE TRANSPORT IN BLOOD.
Testosterone circulates mainly bound to two plasma proteins, sex hormone***8211;binding globulin (SHBG; also known as testosterone-binding globulin) and albumin. In young adult men, about 54% of testosterone is bound to albumin, 44% is bound to SHBG, and 2 to 3% is unbound or free. The SHBG-testosterone fraction is tightly bound and serves a storage role. Bioavailable testosterone refers to the sum of albumin-bound and free testosterone and is measured by separating SHBG-bound testosterone from the total testosterone in the serum. Serum SHBG levels are increased in endogenous and exogenous hyperestrogenemic states, hyperthyroidism, aging, phenytoin treatment, anorexia nervosa, and prolonged stress. SHBG levels are lowered with androgen treatment, obesity, acromegaly, and hypothyroidism. In most instances, measurement of serum total testosterone will detect individuals with androgen deficiency. In conditions with abnormal SHBG levels, the total testosterone measurement (usual laboratory test requested) may be misleading. In these situations, direct measurement of free testosterone by the dialysis method, measurement of bioavailable testosterone, or calculation of the free testosterone by a formula requiring the serum testosterone and SHBG concentrations may be necessary to separate true chemical testosterone deficiency from binding protein problems. Testosterone secretion has a diurnal variation and is highest in the morning in young adult men; this rhythm is blunted or lost with aging.

Nice find Megatron. I don't know how obesity can lower SHBG as the obese tend to be in a hyperestrogenemic state. That seems kind of contradictory to me, but I just play here.

 

[lakers0812]

Agreed that was an excellent find. I found out that my aromasin was empty. I'm going to place an order for more, but could I use adex (temporarily) to decrease shbg in the mean time?

what dose of adex if it is ok to use?

 

[halfwit]

Agreed that was an excellent find. I found out that my aromasin was empty. I'm going to place an order for more, but could I use adex (temporarily) to decrease shbg in the mean time?

what dose of adex if it is ok to use?

Yes, they will both decrease your SHBG. Hmm, you're OFF all exogenous testosterone - so we have to be careful here. I'd start at .25mg E3D and see how that goes. If you start to feel sluggish or have achy joints, I'd go to .25mg E5D and reassess.

 

[Megatron28]

I know next to nothing about the mechanisms that change SHBG levels. So I will be of little help on this one.