Animalkits said:
POP!
I'm sure you are now claiming that they did the test on the the OBESE rats which showed ALA worked and this test entirely different, right?
NOw how could that be t works in one group of obese after extended, but not normal?
the testing procedure was the same, if it were not that would invalidate the results comparatively.
with obese zucker rats the chronic use of r-ala, restores the system to "normal". The impact of a "normal" system last longer than the direct effects of r-ala.
basically while neither the Lean or Obese rats had significant plasma r-ala levels the systemic impact of r-ala(including lowered plasma insulin) over time had a lasting effect (at least more than 15hrs) on the obese zucker. (they are essentially diabetic after all- so the changes will have a greater effect)
It may also be that since Lipoic is lipid soluble that Obese rats may get a longer "effect" period-- though that is purely surmise. And may or may not be part of the issue of variance.
it is important to mention that muscle tissue insulin sensitivity is far more important to those that are already diabetic. Which is why am not sure why this was such a huge arguing point for you. It is the sensitivity of other tissues, like liver, brain, organs, skin, eyes, adipose etc.. that are more important with respect to lean non diabetics.
unfortunately the study with with the lean rats should have been done with a shorter time between r-ala admin and testing to determine this. But that was not what they were looking at, they were looking for extended results.
as all the studies have said- r-lipoic increases insulin sensitivity, glucose clearance and decreases fat mass.
have not argued that it will cause glycogen supercompensation, though many people that use it seem to indicate thus.