THE-DET-OAK
IncreasedMyT @ ULV
Based on the bodies response (as clearly outlined in the study) AR competition is essentially moot given the extended life span the AR exhibits (it more than doubles)when an androgen is bound to it and given that when that occurs the rate of production of new AR's is almost doubled as well. Saying that a stronger androgen will prevent a weaker one from finding or binding a receptor given the increased life span and production rate of AR is pretty foolish . In fact it not only disproves down regulation it also , in all likely hood , makes this entire point your are arguing completely incorrect. It doesnt matter that there is receptor competition ..if there are adequate numbers of receptors present anyway.
No you are misconstruing your outdated study.
first of all who said anything about down regulation?
Second of all how are your leaping from AR doubles, to having plenty of receptors? those are some really good math skills.
if AR is saturated at physiological doses of testosterone, then you take more, and they double, how are you arguing that there is still plenty? as I pointed out many time, by your logic AR up reg is exponential, which would totally disprove the argument of diminishing returns, which has been shown time and time again in studies!!!!!!
So basically what I have been saying all along, is I know what your saying but you are DEAD WRONG!
it is IMPOSSIBLE to think that AR up reg is exponential, cause if you believe that, than you are also dismissing diminishing returns!!!!!!!!!!!
So your argument, based on studies from the 80's and 90's is complete bullshit!!!!!!!!!!
Now as I said earlier, it is possible, that non AR mediated effects, which would also take in to account diminishing returns, is what makes up for gains when receptors are saturated!!!!
With that being said, recapping the point I made earlier, since it is the non AR mediated effects accounting for the very small gains after saturation, then why you would stick a bunch of test in your body to get non AR mediated effects, doubling the chances of your side effects and bloating you up like a hot air balloon!!!!!!!!???????? if its not bound its looking for trouble!
Just because there are no studies on AR competition, doesn't mean its not happening, as a matter of fact, the review I posted clearly points towards it!!!!!!!!!!!!!!!!!!!
Studies in AAS-using human subjects as well as experimental model systems have refuted the decades-old assertion that suprapharmacologic dose regimens of AAS are not anabolic in normal men or are only anabolic due to the impact of their CNS effects on motivation to train. The physiopathology of suprapharmacologic doses of AAS is clearly demonstrated and predicted by the beneficial effects on the same systems when AAS are used in hypogonadal men. However, there has been surprisingly little work on the mechanism by which these suprapharmacologic doses exert their actions or on pharmacologic strategies to distinguish beneficial (anabolic) effects from pathologic side effects on brain and heart. The recent demonstration of clinical benefits of suprapharmacologic regimens (Bhasin et al., 1996,1997,1999,2001) suggests that such developments could be clinically beneficial. A recent review proposed the potential value of exploring the possible tissue specificity of protein regulators of androgen receptor function, comparable to those which have been exploited so successfully in the development of selective estrogen receptor modulators (Negro-Vilar, 1999).
Anabolic Steroids -- Kuhn 57 (1): 411 -- Recent Progress in Hormone Research
Now as far as the dangerous " low test " comment, I have taken tren alone and its not dangerous!!!!!!!!!!!! and has never been proven to be so, and as a matter of fact the study I posted earlier was a study trying to determine if tren would be a viable substitute for TRT!!!!!
So I will say again, your decades old argument, is fucking decades old!!!!!!!!!!!!!! your the one who needs to get a grip!!!
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