RippedZilla's thread of knowledge

Mrrippedzilla

MIA - PM only
I have decided to create a thread where I can post a few things that will, hopefully, be interesting & useful for a lot of you guys/girls :)

I will be posting studies alongside my interpretation of them so members will know how the info is applicable to their specific situations.
I will also be posting some general information I've learnt through a variety of sources, including my own experiences with clients, but I will apologise in advance if these aren't fully referenced - I have a terrible habit of not keeping a record of every study I've been able to utilize over the years.

The topics will be wide ranging & will include:
- AAS, peptides & ancillaries
- the latest data on TRT
- Supplements with particular emphasis being placed on fat loss (since this is my main thing)
- Nutrition
- Training
- General health
- Anything else I personally feel like discussing

I ask you all to PLEASE keep all responses to this thread relevant to the post being discussed.
Any irrelevant gibberish, flaming other members, or any other responses I feel to not belong in here will not be tolerated.
If you have a specific topic you wish me to discuss then PM me & I'll see what I can do - do not list requests in this thread.

With the intro over, lets get started...
 
The first topic was an easy choice...

Is there any evidence for the recommendation to not cycle too young?

This question gets asked by young new guys constantly and its about time we provided some real evidence to back up our stance on not cycling before you reach your mid 20s.
First lets look at the physiological impact aas has if you cycle too early...

http://press.endocrine.org/doi/abs/10.1210/jc.2010-0435

"High-dose sex steroid treatment of boys does not affect their fatherhood or semen quality, as assessed after a mean follow-up of 21 years; however, serum testosterone levels are significantly reduced in androgen-treated tall men...
The treatment of tall stature is based on the understanding that exposure to gonadal steroids leads to epiphyseal fusion of the long bones during pubertal development."

"Leydig cell function was significantly affected by androgen treatment. In treated men, both serum testosterone and non-SHBG-bound testosterone levels were significantly reduced compared with untreated men. We hypothesize that the decreased T levels may be caused by reduced Leydig cell growth during puberty and suboptimal functioning of the Leydig cells in later life."


My interpretation

The group of guys in this study were treated back in the 60s & 70s with sustanon 250 for 1 1/2 years in order to stop them from getting too tall - this was seen as a bad thing back then.
They then did a follow up 21yrs later to see if there were any lasting side effects compared to base levels of untreated men.

The good news was that there was NO negative impact on fertility/sperm quality - this should calm those that fear that they wont be able to have children if they cycle. Although I should add that fertility issues to arise when women cycle but that's another post entirely.
The bad news is that serum T levels were SIGNIFICANTLY lowered for the guys treated with aas during their adolescence, it was still in the normal range but only just - the guys in this study will need to go on TRT at some point in their later years.
The study also shows that steroids are used to REDUCE height growth during puberty, this means that you can forget about getting any taller if you start cycling

The results are not conclusive, but do provide strong evidence for what most of the vets here already know -cycling too young increases the risk of needing TRT in the future because your interfering with your endocrine system before its finished developing.
It also shows that your growth plates will shut the minute you introduce endogenous hormones into your body - so if your still 5'7...:)



I'll next be providing some data about that brain development thing Mega keeps going on about...
 
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Great post ..
Will keep an eye on this one.
You ve been a great valuable member to all of us here.. I hope I could learn more from you.

I also wish ur next subject would be the suplements for fat loss :)
 
Ha this ^^^^ I was going to say the exact same

Yeah man , most of the youngsters here are considering steroids as a fat loss stack which is stupid..
The diet and only diet is what matters when it comes to losing fat, but it will be great also to know about some supplements that could aid in the process ..
EC, CLEN, ALBUTEROL, etc ....
 
if this gets as good as i think it will.. ill be making it a sticky..

write away brother!!
 
Is there any evidence for the recommendation to not cycle too young? Part 2

Ok this is a continuation of the same topic but instead of focusing on the implications for the endocrine system, I will be looking at what impact, if any, early steroid use has on brain development.
Let's start with some solid data...

Androgenic anabolic steroid exposure during adolescence: ramificati... - PubMed - NCBI

"Studies in both humans and animal models indicate that AAS exposure during adolescence alters normal brain remodeling, including structural changes and neurotransmitter function... The evidence suggests that the use of AAS during this critical period of development may increase the risk for maladaptive behaviors along with neurological disorders."

"Specifically, pubertal AAS abuse may contribute to abnormal brain development, or at least alter the normal trajectory of brain development, resulting in increased vulnerability for psychopathological and disorders and maladaptive behaviors."


The Influence of Age of Onset and Acute Anabolic Steroid Exposure o... - PubMed - NCBI

"A growing translational literature suggests that adolescent exposure to anabolic-androgenic steroids (AASs) leads to increased aggression and impulsivity. However, little is known about the cognitive effects of AASs among AAS users or the differences between adolescent- and adult-onset users. Adolescent onset was associated with greater impulsivity and more acute sensitivity to AAS effects on attention. These preliminary findings suggest the possibility that acute AAS use is associated with some differences in inhibitory control and impulsivity and to a lesser degree, aggression. These effects may be more potent for those initiating AAS use in adolescence."


My Interpretation & personal views

Both of these are fairly recent studies providing an insight into the impact aas has neurologically & whether this impact is greater at a younger age.
The first study, which is free to read for everyone, highlights the many behavioural changes that could occur when you interfere with the natural stages of brain remodelling.
The second study is much more relevant since it makes a direct comparison between adolescent aas use vs adult aas use. Although this was a small base with only 11 participants on each side, the authors found clear differences from a behavioural & neurological perspective - with younger use associated with much more pronounced negative changes.

It is commonly accepted that the brain doesn't fully mature until the early to mid 20s.
Is their a direct study illustrating this? Not that I'm aware of but reading through any basic human biology book will give you a fundamental understanding that this is indeed the case.
Or, if your not the reading type, how many people do you know below the age of say...23-25...that are very mature & have excellent behavioural characteristics? Exactly :)
Humans don't grow in an EQUAL manner when it comes to physical & mental maturity - the brain tends to take a more years when compared to the body.

Now IMO, it seems like a very bad idea to introduce large supraphysiological dosages of aas during age-specific developmental periods.
Could it permanently alter the organization of the brain during this important developmental period? Honestly, we don't know but I tend to prefer being cautious when it comes to things like brain development.

To summarise this:
Does early aas use increase the risk of lowering your natural testosterone levels compared to cycling at a later stage? Yes.
Does early aas use increase the risk of develop behavioural & neurological disorders when compared to cycling at a later stage? Yes.
Is it worth risking your physical & mental development in order to cycle a few years earlier? No.
 
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Is there any evidence for the recommendation to not cycle too young? Part 2

Ok this is a continuation of the same topic but instead of focusing on the implications for the endocrine system, I will be looking at what impact, if any, early steroid use has on brain development.
Let's start with some solid data...

Androgenic anabolic steroid exposure during adolescence: ramificati... - PubMed - NCBI

"Studies in both humans and animal models indicate that AAS exposure during adolescence alters normal brain remodeling, including structural changes and neurotransmitter function... The evidence suggests that the use of AAS during this critical period of development may increase the risk for maladaptive behaviors along with neurological disorders."

"Specifically, pubertal AAS abuse may contribute to abnormal brain development, or at least alter the normal trajectory of brain development, resulting in increased vulnerability for psychopathological and disorders and maladaptive behaviors."


The Influence of Age of Onset and Acute Anabolic Steroid Exposure o... - PubMed - NCBI

"A growing translational literature suggests that adolescent exposure to anabolic-androgenic steroids (AASs) leads to increased aggression and impulsivity. However, little is known about the cognitive effects of AASs among AAS users or the differences between adolescent- and adult-onset users. Adolescent onset was associated with greater impulsivity and more acute sensitivity to AAS effects on attention. These preliminary findings suggest the possibility that acute AAS use is associated with some differences in inhibitory control and impulsivity and to a lesser degree, aggression. These effects may be more potent for those initiating AAS use in adolescence."


My Interpretation & personal views

Both of these are fairly recent studies providing an insight into the impact aas has neurologically & whether this impact is greater at a younger age.
The first study, which is free to read for everyone, highlights the many behavioural changes that could occur when you interfere with the natural stages of brain remodelling.
The second study is much more relevant since it makes a direct comparison between adolescent aas use vs adult aas use. Although this was a small base with only 11 participants on each side, the authors found clear differences from a behavioural & neurological perspective - with younger use associated with much more pronounced negative changes.

It is commonly accepted that the brain doesn't fully mature until the early to mid 20s.
Is their a direct study illustrating this? Not that I'm aware of but reading through any basic human biology book will give you a fundamental understanding that this is indeed the case.
Or, if your not the reading type, how many people do you know below the age of say...23-25...that are very mature & have excellent behavioural characteristics? Exactly :)
Humans don't grow in an EQUAL manner when it comes to physical & mental maturity - the brain tends to take a more years when compared to the body.

Now IMO, it seems like a very bad idea to introduce large supraphysiological dosages of aas during age-specific developmental periods.
Could it permanently alter the organization of the brain during this important developmental period? Honestly, we don't know but I tend to prefer being cautious when it comes to things like brain development.

To summarise this:
Does early aas use increase the risk of lowering your natural testosterone levels compared to cycling at a later stage? Yes.
Does early aas use increase the risk of develop behavioural & neurological disorders when compared to cycling at a later stage? Yes.
Is it worth risking your physical & mental development in order to cycle a few years earlier? No.
hearing this make me feel like we have been beating a dead horse with a stick..

waiting for the next 18-23 year old posting about wanting to do gear lol
 
Exercise selection for bodybuilding - Part 1

I want to make a few things clear before diving into this topic because I was hesitant to write this article to begin with...

- For guys on cycle how you train becomes much less relevant because the drugs in your system will allow you to grow muscle even if you do NO training whatsoever.
However, that does NOT mean that an optimal training programme isn't necessary to maximise your gains on cycle:

The effects of supraphysiologic doses of testosterone on muscle siz... - PubMed - NCBI

In this awesome study the authors did an important comparison between:
- Guys doing resistance training with no exogenous test supplementation aka "natties"
- Guys taking 600mg test with no resistance training
- Guys taking 600mg test with resistance training

Caloric consumption was set at 36cals/kg of bodyweight with protein consumption set at 1.5g/kg of bodyweight for all the groups.
Training for all groups consisted of 3 non-consecutive days of heavy (90% 1rm), moderate (80% 1rm) & light intensity (70% 1rm) work for 4 sets x 6 reps increased to 5 sets x 6 for the final 5 weeks.

The study took a total of 30 weeks - this included the training & recovery periods (pct, etc) - and the guys on 600mg test ended their cycle after 10 weeks.

After 30 weeks, here are the important muscle mass results:
- Natties gained 1.9kg (4 pounds) of muscle, which is pretty standard gains for any but the elite naturals
- The guys on test with NO exercise gained 3.2kg (7 pounds) of muscle
- The guys on test and a training stimulus gained 6.1kg (13.5 pounds) of muscle

Now, as you can see it is an absolute FACT that you can indeed sit on your ass all day and still gain more muscle on a standard test cycle then a natural can in a year of dieting & training perfection. 7 pounds is pretty much the maximum a natural can gain in a year, never mind 7 1/2 months of zero workouts.
The reason that this is an important discovery is that I see way too many enhanced guys telling natties that they are making more gains because they are working harder, not because of the drugs - this is bullshit & you need to stop spreading it :)
I know some of you will criticize me for telling guys that they can pretty much sit on their asses and still gain muscle on a Pharma grade test cycle. However, I believe in telling the truth & if your not a fan of my approach then stop reading my stuff - simple solution.

Now before you start thinking that training is completely irrelevant - look at the gains made by the test + training group.
13.5 pounds, almost double the test only group & more than 3 times what a natty could do. An optimal training routine will significantly maximise the muscle gains you make on cycle, IMO this is a strong enough reason to create your own elite resistance training routines.

Summary:
- Naturals HAVE to train in order to make any muscle gains at all, enhanced guys don't.
- An optimal training routine will still allow an enhanced guy to almost DOUBLE his muscle mass gains, highlighting the importance of a good training protocol even when on cycle.

Hopefully you guys now have a good understanding of the importance of optimal training for muscle gains & I will get into the actual exercise selection principles in part 2 since part 1 is too long as it is.
 
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Posting that took some balls as nobody wants to give the drugs their due credit. We all know diet is king, but feel forced to downplay the effects of AAS as many come here looking for a shortcut.

Excellent thread sir, you are indeed an asset for the forum. :)
 
Rip any idea what the dietary intake was on the study?

Calories were set at 36cals per kg of bodyweight, so for an average 200 pound dude that's 3270 cals.
Protein intake was set at 1.5g per kg of bodyweight, again for a 200 pound dude that's 140g protein.
No significant changes in bf% for any of the groups.
 
Posting that took some balls as nobody wants to give the drugs their due credit. We all know diet is king, but feel forced to downplay the effects of AAS as many come here looking for a shortcut.

Excellent thread sir, you are indeed an asset for the forum. :)
I agree.. Usually I would rip on someone who made statements like this just because I worry about what inexperienced or new steroid users would take it as... But its an undeniable fact... I was suspicious of the study because he didn't post nutrition details but after seeing what's been said it looks pretty solid
 
I agree.. Usually I would rip on someone who made statements like this just because I worry about what inexperienced or new steroid users would take it as... But its an undeniable fact... I was suspicious of the study because he didn't post nutrition details but after seeing what's been said it looks pretty solid

Your right, I've edited the post to include the calories/protein intake I mentioned as well as the training stimulus the guys were placed on.
 
What's beautiful about the study and could be irrelevant is the muscle you can gain on test only cycle @ 600 Mgs per week , and yet we see people using mega doses with lots of side effects..

Another reason for me to stay on test only cycles , I'm done with 19-Nors specially I'm almost 40 and still pct-ing.
 
Guys I really dont want to be a pain in the ass, but can we please keep this thread relevant to the knowledge.
I did say very specifically that I would only post in here if irrelevant chitchat was avoided, and I hate to have to constantly repeat myself.

Anyway, the final part of the exercise selection article will be up shortly...
 
Exercise selection for bodybuilding - Part 1

I want to make a few things clear before diving into this topic because I was hesitant to write this article to begin with...

- For guys on cycle how you train becomes much less relevant because the drugs in your system will allow you to grow muscle even if you do NO training whatsoever.
However, that does NOT mean that an optimal training programme isn't necessary to maximise your gains on cycle:

The effects of supraphysiologic doses of testosterone on muscle siz... - PubMed - NCBI

In this awesome study the authors did an important comparison between:
- Guys doing resistance training with no exogenous test supplementation aka "natties"
- Guys taking 600mg test with no resistance training
- Guys taking 600mg test with resistance training

Caloric consumption was set at 36cals/kg of bodyweight with protein consumption set at 1.5g/kg of bodyweight for all the groups.
Training for all groups consisted of 3 non-consecutive days of heavy (90% 1rm), moderate (80% 1rm) & light intensity (70% 1rm) work for 4 sets x 6 reps increased to 5 sets x 6 for the final 5 weeks.

The study took a total of 30 weeks - this included the training & recovery periods (pct, etc) - and the guys on 600mg test ended their cycle after 10 weeks.

After 30 weeks, here are the important muscle mass results:
- Natties gained 1.9kg (4 pounds) of muscle, which is pretty standard gains for any but the elite naturals
- The guys on test with NO exercise gained 3.2kg (7 pounds) of muscle
- The guys on test and a training stimulus gained 6.1kg (13.5 pounds) of muscle

Now, as you can see it is an absolute FACT that you can indeed sit on your ass all day and still gain more muscle on a standard test cycle then a natural can in a year of dieting & training perfection. 7 pounds is pretty much the maximum a natural can gain in a year, never mind 7 1/2 months of zero workouts.
The reason that this is an important discovery is that I see way too many enhanced guys telling natties that they are making more gains because they are working harder, not because of the drugs - this is bullshit & you need to stop spreading it :)
I know some of you will criticize me for telling guys that they can pretty much sit on their asses and still gain muscle on a Pharma grade test cycle. However, I believe in telling the truth & if your not a fan of my approach then stop reading my stuff - simple solution.

Now before you start thinking that training is completely irrelevant - look at the gains made by the test + training group.
13.5 pounds, almost double the test only group & more than 3 times what a natty could do. An optimal training routine will significantly maximise the muscle gains you make on cycle, IMO this is a strong enough reason to create your own elite resistance training routines.

Summary:
- Naturals HAVE to train in order to make any muscle gains at all, enhanced guys don't.
- An optimal training routine will still allow an enhanced guy to almost DOUBLE his muscle mass gains, highlighting the importance of a good training protocol even when on cycle.

Hopefully you guys now have a good understanding of the importance of optimal training for muscle gains & I will get into the actual exercise selection principles in part 2 since part 1 is too long as it is.

in the study the exercise group was only working out 3 times per week. would it be fair to assume that working out 6 days a week would provide even more muscle and strength in the same amount of time?
 
in the study the exercise group was only working out 3 times per week. would it be fair to assume that working out 6 days a week would provide even more muscle and strength in the same amount of time?

No.

All the data shows that 3-4x a week is more than sufficient provided each muscle group is hit 2x week - so a classic upper/lower split for example.
In the study, they did full body workouts so each muscle got hit 3x week - more than enough.

On cycle you can obviously recover faster, which allows you train more often if you wish, but there is ZERO evidence to suggest that training more will equal more growth.
More is not better when it comes to training frequency & volume, something I will go into at a later date :)
 
More is not better when it comes to training frequency & volume, something I will go into at a later date :)

It will be great to share your experience on this one ..

When u say upper body u mean to train chest , shoulders , back , bi and tris in one day ?

I've checked a post written by lyle mcdonalds instructing the same , but I felt lost when It comes to sets and reps if we take such approach ..specially if we have to finish all those groups in 1 h 30 min..
 
Exercise selection for bodybuilding - Part 2

Let me start by saying that this article was an absolute pain in the ass to write up.

Due to the fact that people tend to have widely varying biomechanics, such as hip/knee/shoulder mobility, limb length & upper body width, its very difficult to create "fixed" rules for exercise selection. This also explains why many folks don't bother to write such articles.
So I'll say straight away that the MAJORITY of people will benefit by implementing these rules, but not necessarily everyone.
I will also note that this is not a complete list, so I reserve the right to come back at a later date to edit it as I wish :)

A few points to note before we head over to the rules:
- I highly recommend beginners experiment with many different movements to find what works for them. These rules will still help them, but I'd rather they gain some experience of their own biomechanical advantages/disadvantages along with seeing what type of movements they actually enjoy (this plays a part in being motivated to workout) before deciding on a fixed selection of exercises.
- All the rules I'm about to highlight come with the following supplementary information: You must enjoy the movements you do. There is NO point choosing a bunch of great exercises on paper, if you don't have the drive to go & kill it come gym time.
- A partial list of references will be provided but all are unavailable for public viewing, which is why I haven't mentioned specific ones within the article.


Finally, here are the rules...


1 - The targeted muscle must be the first to fail

An exercise is most effective for a muscle group if the limiting factor, or the part that forces you to fail, is the muscle that is being targeted.
For example for inverted rows your grip fails first, which makes it a poor choice to stimulate the lats.
This rule eliminates almost all unstable exercises because your core stabilizing muscles will always fail first. This will include standing one leg movements like split squats, and standing overhead single arm presses because your forearms & rotator cuff will fail long before your delts do.

This rule allows you to focus on the targeted muscle rather than having other muscles limiting you in the progression you could achieve.

2 - Compounds first, isolation second

Compounds place higher hormonal & neurological demands on your body, which allows muscle & strength gains to occur over a shorter period of time. Let's face it, the guy who has a big bench press will always be more developed than someone who sticks to cable flyes & tricep extensions.
Compounds also tend to be a more "natural" way to move your body & tend to satisfy the other rules in this article more than isolation exercises.

This does NOT mean that you should avoid isolation exercises, they still play a role especially when it comes to bringing up lagging muscle groups. The key is to not prioritise the isolation moves over the compounds.
For example you can still use bicep curls in your program, but only if your already doing some horizontal pulling compounds.

3 - Tissue stress distribution based on biomechanics

The more a movement stresses the targeted muscle group, and the less it stresses the surrounding tissues, the better the movement.
This is where the biomechanics I mentioned at the start play a major role. Its extremely important to avoid movements that cause pain because this is a good sign that your joints & tendons are being placed under an unnecessary amount of stress.

Its difficult to give specific advice here because biomechanics vary greatly from person-to-person but here are some general tips:

- Your body has not been designed to push things behind you; major shoulder stress can occur due to the unnatural style of the movement. This means that exercises such as behind the neck presses & dips should be excluded.

- Your core (abs & lower back) are designed to stabilize your body NOT to flex backwards & forwards, which creates a lot of problems for your spine. Avoid any movements that force you to round your back and not maintain a neutral spine position. This neutral position is optimal for maximum core activation with minimal peripheral tissue stress.

- The more an exercise keeps you fixed into a specific movement pattern, the worse the exercise. Basically dumbbells are the best choice, followed by barbells & then machines (which have really poor tissue distribution).

- Closed kinetic chain exercises are better than open kinetic chain exercises.
If your body is moving during the exercise = closed kinetic chain
If the weight is moving = open kinetic chain
Multiple studies have proven that closed chain exercises are superior for both your joints & muscles. This is why squats are superior to leg presses and why rows/military presses are not perfect.
Another good example is barbell bench vs smith machine bench = same muscle activity but more stress on the joints with the smith machine due to the extra weight being handled & the fixed nature of the movement.

4 - Movements must have an eccentric & concentric portion

Exercises that contain an eccentric & concentric portion are superior to those that are only isometric, concentric or eccentric.
There is a lot of broscience focusing only on the eccentric portion but according to a systematic review & meta-analysis, here is the order of movements in order of most effective for muscle growth to least:
1: Eccentric-concentric contractions
2: Isometric contractions
3: Concentric only contractions
4: Eccentric only contractions

Eccentric-concentric contractions are superior because they're easier on the joints and they allow a higher rate of force to be produced during the concentric phase compared to concentric only movements.
Notice that eccentric only is also the worst method for muscle growth.

5 - The strength curve should be equal to the resistance curve

If these curves don't match then some muscles will remain understimulated & you end up with lagging muscle groups with imbalances. To explain this in simple terms: you want the point at which you fail to be the point at which your undeveloped parts fail. This way you'll be able to develop all the muscles involved in a lift in a balanced manner.

Plenty of exercises have a constant resistance curve such as vertical lifting movements (since the weight is battling against gravity). But some, such as bicep curls & leg extensions, have clear points were the muscle is under no tension whatsoever. For example on bicep curls, the biceps are under minimal resistance at the bottom of the move and maximum at about 90 degrees.

Determining your strength curve

The easiest way would be to focus on what part of a movement your at your strongest & and what point are you consistently failing.
In general, your muscles are strongest in their natural positions (think military posture).
So for pushing movements, your strength is lowest at the start or halfway through the concentric portion of the movement (since your arms are bent & in an unnatural position).
For overhead presses & squats, your more likely to fail at the bottom of the movement before the halfway point.
For pulling movements your generally weakest at the end of the concentric portion (touching the bar to your chest on rows, etc).
Hopefully you get the idea.

How can you match your strength curve to the exercise's resistance curve?

The main way to do this is to focus on the stretch-reflex technique, which is similar to using strategic momentum at certain points of a lift where the resistance is poor.
If we take face pulls for example, the strength curve decreases as you move along the concentric portion - making the move really easy to begin with & more difficult as the bar approaches your face. Therefore, the move will benefit from using momentum to explosively move the bar towards your face.

6 - Micro loading

The more precisely you can alter a movement's resistance, the better the movement.
Ideally, you want choose exercises that let you move gradually towards larger weights.
This is major disadvantage to bodyweight exercises because it simply isn't possible to move towards a maximum load. For example, handstand pushups are superior to overhead presses in terms of their kinetic chain (closed vs open) but vastly inferior when it comes to loading.
Depending on the gym you go to, most machines have fixed weight increases and dumbbells/barbell plates tend to go up by 5-10 pounds. These increases may be fine when improving your squat, but the weight will be far too heavy for shoulder isolation work.

Ideally, you want to increase your lifts by a fixed percentage rather than a fixed weight - but I accept that this may be out of your control.

Appling these rules

Let's look at the conventional deadlift.
Now a lot of guys are going to be butthurt by this but as I said before - if you don't like the truth I preach then don't read my stuff.

Conventional deadlifts SUCK for building muscle based on the rules I gave above.
Firstly, its a purely concentric move with no eccentric portion at all - a major disadvantage to building muscle if you read rule 3.
Secondly, deadlifts are supposed to target your legs yet your lower back & grip will inevitably fail first.
Some of you will say "well deadlifts are still good for lower back & forearm growth" yea...no they're not. Both of these muscle groups are slow-twitch dominant and therefore require high reps for optimal growth. But doing high volume deadlifts will completely fry your CNS (central nervous system) making you way too tired to do anything else during that workout.

I don't have an issue with some deadlift variations, like the Romanian or stiff-legged varieties, but the conventional deads simply suck for building muscle. Its a good jack of all trades move, but that's about it.


Summary

In order to make intelligent exercise choices for your routine, the chosen movements must:
- Allow the target muscle to fail first
- Preferably be a compound move, with isolation work only used as an accessory
- Not put too much stress on peripheral tissues with a preference towards closed kinetic chain exercises & "natural" movements based on your individual biomechanics.
- Have an eccentric & concentric portion to the move.
- Match your strength curve to the resistance curve of the movement by utilizing the stretch-reflex technique.
- Be capable of being loaded with more intensity, preferably in micro amounts.




References

A comparison of muscle activation between a Smith machine and free weight bench press. Schick EE, Coburn JW, Brown LE, Judelson DA, Khamoui AV, Tran TT, Uribe BP. J Strength Cond Res. 2010 Mar;24(3):779-84. Erratum in: J Strength Cond Res. 2011 Jan;25(1):286.

A comparison of tibiofemoral joint forces and electromyographic activity during open and closed kinetic chain exercises. K E Wilk, R F Escamilla, G S Fleisig, S W Barrentine, J R Andrews, M L Boyd. Am J Sports Med. 1996 Jul;Aug; 24(4): 518;527.

Effects of lifting tempo on one repetition maximum and hormonal responses to a bench press protocol. Headley SA, Henry K, Nindl BC, Thompson BA, Kraemer WJ, Jones MT. J Strength Cond Res. 2011 Feb;25(2):406-13.

Quadriceps activation in closed and in open kinetic chain exercise. Ann-Katrin Stensdotter, Paul W Hodges, Rebecca Mellor, Gunnevi Sundelin, Charlotte Häger-Ross. Med Sci Sports Exerc. 2003 December; 35(12): 2043;2047.

Quadriceps EMG/force relationship in knee extension and leg press. B A Alkner, P A Tesch, H E Berg. Med Sci Sports Exerc. 2000 February; 32(2): 459;463.

The constrained control of force and position in multi-joint movements. G J van Ingen Schenau, P J Boots, G de Groot, R J Snackers, W W van Woensel. Neuroscience. 1992; 46(1): 197;207.

The influence of frequency, intensity, volume and mode of strength training on whole muscle cross-sectional area in humans. Mathias Wernbom, Jesper Augustsson, Roland Thomeé. Sports Med. 2007; 37(3): 225;264.
 
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