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StoneColdNTO said:
So I take it an Aromatase inhibitor (AI) would reduce water retention/bloat then, correct?
Tamoxifen citrate increases expression of progesterone receptor.
- Thread starter Vegas
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So I take it an Aromatase inhibitor (AI) would reduce water retention/bloat then, correct?
Tamoxifen inhibits prolactin signal transduction in ER - NOG-8 mammary epithelial cells.
Das R, Vonderhaar BK.
Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892-1402, USA.barbarav@helix.nih.gov
Tamoxifen (TAM), an antiestrogen, also acts as an antilactogen in mammary cells. In the present study we analyze the effect of TAM on the signal transduction pathway for prolactin (Prl). TAM bound specifically to NOG-8, an estrogen receptor-negative mammary cell line. Within 5 min of Prl treatment, raf-1, MEK and MAP kinase were induced 2-3-fold over the control level. TAM completely inhibited this Prl-induced activation of kinases as well as Prl binding and cell growth. These results indicate the potential role of TAM as an antilactogen in Prl responsive systems.
PMID: 9177456 [PubMed - indexed for MEDLINE]
Effectiveness of antiestrogens in infertile men.
Breznik R, Borko E.
Gynecology Department, Maribor Teaching Hospital, Maribor, Slovenia.
Eighty-nine oligozoospermic men, treated by clomiphene or tamoxifen or with no treatment at all, were evaluated during a 4-year follow-up period. Ejaculate volume, sperm concentration, and sperm motility were determined and concentrations of prolactin (PRL), estradiol, beta hCG, prostaglandin E2, zinc, and fructose were ascertained. Isoenzyme LDH-C4 activity and serum PRL and follicle stimulating hormone were also determined. During treatment there was only a minimum increase in sperm concentration. No improvement in sperm motility and no alteration in ejaculate volume were observed. The pregnancy rate was lower in the partners of patients receiving treatment (23.8%) than in the partners of those receiving none (29.6%). Statistically the difference is insignificant. After antiestrogen therapy, prolactin concentrations in serum decreased and zinc concentrations in seminal plasma increased. For the treatment of idiopathic oligozoospermia in infertile men, clomiphene and tamoxifen were ineffective medication.
Publication Types:
* Clinical Trial
PMID: 8373285 [PubMed - indexed for MEDLINE]
Das R, Vonderhaar BK.
Laboratory of Tumor Immunology and Biology, National Cancer Institute, Bethesda, MD 20892-1402, USA.barbarav@helix.nih.gov
Tamoxifen (TAM), an antiestrogen, also acts as an antilactogen in mammary cells. In the present study we analyze the effect of TAM on the signal transduction pathway for prolactin (Prl). TAM bound specifically to NOG-8, an estrogen receptor-negative mammary cell line. Within 5 min of Prl treatment, raf-1, MEK and MAP kinase were induced 2-3-fold over the control level. TAM completely inhibited this Prl-induced activation of kinases as well as Prl binding and cell growth. These results indicate the potential role of TAM as an antilactogen in Prl responsive systems.
PMID: 9177456 [PubMed - indexed for MEDLINE]
Effectiveness of antiestrogens in infertile men.
Breznik R, Borko E.
Gynecology Department, Maribor Teaching Hospital, Maribor, Slovenia.
Eighty-nine oligozoospermic men, treated by clomiphene or tamoxifen or with no treatment at all, were evaluated during a 4-year follow-up period. Ejaculate volume, sperm concentration, and sperm motility were determined and concentrations of prolactin (PRL), estradiol, beta hCG, prostaglandin E2, zinc, and fructose were ascertained. Isoenzyme LDH-C4 activity and serum PRL and follicle stimulating hormone were also determined. During treatment there was only a minimum increase in sperm concentration. No improvement in sperm motility and no alteration in ejaculate volume were observed. The pregnancy rate was lower in the partners of patients receiving treatment (23.8%) than in the partners of those receiving none (29.6%). Statistically the difference is insignificant. After antiestrogen therapy, prolactin concentrations in serum decreased and zinc concentrations in seminal plasma increased. For the treatment of idiopathic oligozoospermia in infertile men, clomiphene and tamoxifen were ineffective medication.
Publication Types:
* Clinical Trial
PMID: 8373285 [PubMed - indexed for MEDLINE]
Effects of tamoxifen on estrogen and progesterone receptors in human breast cancer
N Waseda, Y Kato, H Imura and M Kurata
Twenty patients with primary breast cancer were treated with tamoxifen (10 mg p.o. twice a day) for 1 to 4 weeks. Before and after the tamoxifen administration, tumor specimens were obtained and assayed for estrogen receptors and progesterone receptors (PGR). Total cytosol estrogen receptor (ERC) and occupied nuclear estrogen receptor (ERN) were measured by hydroxylapatite assay, and unoccupied PGR was measured by the dextran-coated charcoal assay. ERC, ERN, and PGR were detectable in 11, 8, and 6 tumors, respectively, before tamoxifen administration. After tamoxifen treatment, ERC decreased in 10 of 11 ERC-positive tumors. Occupied ERN increased in three of five ERN-positive tumors treated with tamoxifen for a short period (1 to 2 weeks), but they decreased in all of three ERN-positive tumors after longer administration (3 to 4 weeks). PGR increased in three of five ERN-positive tumors after short-term tamoxifen treatment, but they decreased in all of three tumors treated by the drug for a longer period. Increased PGR responses were accompanied by an increase of ERN in two of three ERN-positive tumors. These results suggest that tamoxifen interacts with the estrogen receptor system in human breast cancer tissue and may be estrogenic during short treatment, while longer treatment results in an antiestrogenic response.
N Waseda, Y Kato, H Imura and M Kurata
Twenty patients with primary breast cancer were treated with tamoxifen (10 mg p.o. twice a day) for 1 to 4 weeks. Before and after the tamoxifen administration, tumor specimens were obtained and assayed for estrogen receptors and progesterone receptors (PGR). Total cytosol estrogen receptor (ERC) and occupied nuclear estrogen receptor (ERN) were measured by hydroxylapatite assay, and unoccupied PGR was measured by the dextran-coated charcoal assay. ERC, ERN, and PGR were detectable in 11, 8, and 6 tumors, respectively, before tamoxifen administration. After tamoxifen treatment, ERC decreased in 10 of 11 ERC-positive tumors. Occupied ERN increased in three of five ERN-positive tumors treated with tamoxifen for a short period (1 to 2 weeks), but they decreased in all of three ERN-positive tumors after longer administration (3 to 4 weeks). PGR increased in three of five ERN-positive tumors after short-term tamoxifen treatment, but they decreased in all of three tumors treated by the drug for a longer period. Increased PGR responses were accompanied by an increase of ERN in two of three ERN-positive tumors. These results suggest that tamoxifen interacts with the estrogen receptor system in human breast cancer tissue and may be estrogenic during short treatment, while longer treatment results in an antiestrogenic response.
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BIG BUMP FOR ALL TO READ!!!!!!! Bumpity.. bump Great, sound information aboot thanks
RRADAM is my idol...he already knows that though
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