For me, too low e2 results in anxiety, emotional flat lined, joint pain comes when it is too low for too low for too long however don't find there to be much worse than it already can get. Muscles do not look full at all, basically like I woke up and haven't eaten yet non stop and strength is also reduced along with intensity. Sex drive lowers and can not keep hard.
Taking 25mg stane, within 6 hours I feel all of the above come on especially a pronounced wave of anxiety.