Wellbutrin and Tamoxifen are a NO NO!!!

[cybrsage]

I was just shifted from using an SSRI to using Wellbutrin XL, due to the horrific sexual side effects the SSRI was giving me. Wellbutrin, aka bupropion hydrochloride, is known for having no sexual side effects (or very light ones). The BIG issue for AAS users is that Wellbutrin has dangerous results if you take it and Tamoxifen at the same time. Raloxifene has no bad interactions with Wellbutrin, so use it instead of Tamoxifen since Tamox is a CYP2D6 inhibitor and Ralox does not interact with that enzyme at all. Ralox is better than Tamox anyway.

Basically, Wellbutrin will cause Tamox to not work properly (meaning it will not take care of your gyno issue) AND can make it cause an irregular heatbeat.


Just a heads up to everyone, since both Wellbutrin and Tamox are commonly used.

 

[bonexyster]

Cyp is an enzyme that tamoxifen requires to adequately attach to breast tissue. Wellbutrin stops the body's production of cyp. Raloxifene doesn't require the enzyme to attach to breast tissue. Raloxifene only showed 4% better results at removing gyno over tamoxifen and there were only 300 people in the study that came to that conclusion. Many medical studies have 2500 patients participate in the studies, the results may be accurate they could be 10% for either medication. The one thing that is conclusive is that tamox is a better pct medication because it can raise test 4x higher then raloxifene.

 

[jozifp103]

Good stuff CS. It's crazy how some drugs can react to each other.

 

[Mrrippedzilla]

On the plus side, Wellbutrin is pretty good for fat loss due to the fact that it's a norepinethrine/dopamine reuptake inhibitor (causes an increase in metabolism).

When combined with a suitable appetite suppressant, like naltrexone (opioid antagonist), the awesomeness can be doubled - just some food for thought