reallittleguy
New member
JohnnyB said:
Thanks JohnnyB
What type of results have you seen?
What time of the day to take HGH
- Thread starter reallittleguy
- Start date
Thanks JohnnyB
What type of results have you seen?
reallittleguy
New member
Lawnsaver, Will you increase your IU when your between cycles or stay the same.
reallittleguy
New member
Thanks Lawnsaver.
LAWNSAVER
New member
WannaImpress said:That is what I'm looking for myself LS, ofcourse once I decide to get some.I'm very interested in your results so do keep us posted, by the way, if you don't me asking at what age did you start using GH?
I used GH at 25, 27, 28, and now, which i am 30.
The first 3 times were 12 weeks with 1 kit of serostim.
einstein1905
Banned
Thanks for the kind words, guys. Lots of good heads over here too BTW.
You will hear pretty much any big time BBer say that they take their GH at night....this makes sense. What you have to consider is their doses are far above what we're typically using. Many guys are in the 10IU and beyond neighborhood, so when you consider endogenous productionto exo GH intake, endo GH is relatively insignificant, so inhibiting endo GH is relatively minor. We can all agree that the majority of growth/repair occurs during sleep, so having an abundant supply of GH and IGF-1 during this time would be a good idea. For those of us that use doses of 2-5IUs or so, the contribution of our endogenous GH is pretty significant in relation. If money and GH supply is of no issue, then use higher dose GH at night. I won't even attempt to argue that there is a better way than that. however, at the lower doses, we still have the ability to reap the benefits of our endo GH, simply by timing the exo GH injects correctly.
Not only are the old GH studies (that show the ~18hr suppression or so) old, but they are also counterintuitive. the doses used were not high, and weren't much higher than a typical phase IV sleep "pulse" of GH. We know that endo GH is regulated mainly by IGF-1 levels, and that GH pulses occur about every 3-5hrs or so, which mean the waxing and waning of IGF-1 levels follow this same wave. How then would introducing GH via injection cause 2-4x the duration of persistently high IGF-1 levels? The fact is that older studies almost always have assay sensitivity issues. There were also only two studies that we can refer to (if we don't use the rat studies, which I believe are perfectly indicative of mammalian endocrinology, in general). You can find studies to contradict each other on almost any subject (like arimidex increasing IGF-1 levels, which it does.....however, there are 1 or 2 studies showing decreases in IGF-1 levels with adex too......but there are enough studies out there, so we can see which are the outliers and what the trend really is and draw a conclusion). In our case, we're limited to only 2 human studies. BUT, we do have extensive knowledge of how GH and IGF-1 are regulated, and their relative half-lives, and the 2 GH studies go against these numbers IMO.
I think you know where I stand on this, but to reiterate, I use an AM dose and an early afternoon dose.
Hey there, JB, Lawnsaver, DrVJ
You will hear pretty much any big time BBer say that they take their GH at night....this makes sense. What you have to consider is their doses are far above what we're typically using. Many guys are in the 10IU and beyond neighborhood, so when you consider endogenous productionto exo GH intake, endo GH is relatively insignificant, so inhibiting endo GH is relatively minor. We can all agree that the majority of growth/repair occurs during sleep, so having an abundant supply of GH and IGF-1 during this time would be a good idea. For those of us that use doses of 2-5IUs or so, the contribution of our endogenous GH is pretty significant in relation. If money and GH supply is of no issue, then use higher dose GH at night. I won't even attempt to argue that there is a better way than that. however, at the lower doses, we still have the ability to reap the benefits of our endo GH, simply by timing the exo GH injects correctly.
Not only are the old GH studies (that show the ~18hr suppression or so) old, but they are also counterintuitive. the doses used were not high, and weren't much higher than a typical phase IV sleep "pulse" of GH. We know that endo GH is regulated mainly by IGF-1 levels, and that GH pulses occur about every 3-5hrs or so, which mean the waxing and waning of IGF-1 levels follow this same wave. How then would introducing GH via injection cause 2-4x the duration of persistently high IGF-1 levels? The fact is that older studies almost always have assay sensitivity issues. There were also only two studies that we can refer to (if we don't use the rat studies, which I believe are perfectly indicative of mammalian endocrinology, in general). You can find studies to contradict each other on almost any subject (like arimidex increasing IGF-1 levels, which it does.....however, there are 1 or 2 studies showing decreases in IGF-1 levels with adex too......but there are enough studies out there, so we can see which are the outliers and what the trend really is and draw a conclusion). In our case, we're limited to only 2 human studies. BUT, we do have extensive knowledge of how GH and IGF-1 are regulated, and their relative half-lives, and the 2 GH studies go against these numbers IMO.
I think you know where I stand on this, but to reiterate, I use an AM dose and an early afternoon dose.
Hey there, JB, Lawnsaver, DrVJ
reallittleguy
New member
einstein, What do you consider an early afternoon dose. 2 or 3 o'clock or a little later. And would you still split up 2 IU's.
Drveejay11
Community Veteran
einstein1905 said:Thanks for the kind words, guys. Lots of good heads over here too BTW.
You will hear pretty much any big time BBer say that they take their GH at night....this makes sense. What you have to consider is their doses are far above what we're typically using. Many guys are in the 10IU and beyond neighborhood, so when you consider endogenous productionto exo GH intake, endo GH is relatively insignificant, so inhibiting endo GH is relatively minor. We can all agree that the majority of growth/repair occurs during sleep, so having an abundant supply of GH and IGF-1 during this time would be a good idea. For those of us that use doses of 2-5IUs or so, the contribution of our endogenous GH is pretty significant in relation. If money and GH supply is of no issue, then use higher dose GH at night. I won't even attempt to argue that there is a better way than that. however, at the lower doses, we still have the ability to reap the benefits of our endo GH, simply by timing the exo GH injects correctly.
Not only are the old GH studies (that show the ~18hr suppression or so) old, but they are also counterintuitive. the doses used were not high, and weren't much higher than a typical phase IV sleep "pulse" of GH. We know that endo GH is regulated mainly by IGF-1 levels, and that GH pulses occur about every 3-5hrs or so, which mean the waxing and waning of IGF-1 levels follow this same wave. How then would introducing GH via injection cause 2-4x the duration of persistently high IGF-1 levels? The fact is that older studies almost always have assay sensitivity issues. There were also only two studies that we can refer to (if we don't use the rat studies, which I believe are perfectly indicative of mammalian endocrinology, in general). You can find studies to contradict each other on almost any subject (like arimidex increasing IGF-1 levels, which it does.....however, there are 1 or 2 studies showing decreases in IGF-1 levels with adex too......but there are enough studies out there, so we can see which are the outliers and what the trend really is and draw a conclusion). In our case, we're limited to only 2 human studies. BUT, we do have extensive knowledge of how GH and IGF-1 are regulated, and their relative half-lives, and the 2 GH studies go against these numbers IMO.
I think you know where I stand on this, but to reiterate, I use an AM dose and an early afternoon dose.
Hey there, JB, Lawnsaver, DrVJ
Einstein = STUD!!!!
Great to see ya here bro.
Drveejay11
Community Veteran
reallittleguy said:
I'm sure that's perfect
reallittleguy said:
I woudn't waste your time!
BUMP for Einstein ^^
LAWNSAVER
New member
JohnnyB said:
Food for thought...
All Hormone Replacement Therapy (HRT) Docs are now prescribing GH to be taken in the AM and afternoon.
I forget which brand it is, but the insert actually tells you if you are Hormone Replacement Therapy (HRT) to take 2 doses during the day. If you have HIV, take all before bed.
The depot eliminated all the guess work.
einstein1905
Banned
JohnnyB said:
Relevance is the main reason. When you attempt to get funding for research, you have to convey how your work has relevance to the scientific world in general, but more soecificaly with clinical trials, how it'll have clinical relevance. GH is prescribed primarily to those defficient in GH, so the impact on endo GH isn't a factor.
If GH becomes more commonly used for HIV and those suffering from cachexia, then there may be more motivation for people to further explore this.
Also, the more we lean about ours and animals physiology, the more we can determine what aspects of our physiology are comparable. For instance, the immune system; rats and mice have immune responses that are not very comparable to humans. their endocrine system, however, is remarkably similar.
I'm actually talking to an Hormone Replacement Therapy (HRT) doc that may redo the old GH studies, off the books. Just use some of his patients and test IGF-1 levels at various time points after GH administration. This will give you the IGF-1 vs. time graph, so that you can see just how long it takes for IGF-1 levels to peak (versus normal IGF-1 levels at the same time points), and this will correlate to endo GH suppression.
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