who splits their t3 dosage?

[brooklynheight]

the profile says to split t3 dosage to keep blood levels even

however one guy i know who is prescribed t4 is told to take it
in the a.m on an empty stomach

 

[Rokomuscle1]

Dr's that I know have people take them all in the morning.. why I don't know..just thought I would throw that out there...

 

[RRAdam]

The only thing I could think of is that t4 has a longer half life, as it circulates, then is metabolized to t3 in the body. t3 has a shorter half life.

That being said - i split my doses... i want to maximize my metabolisim, not simulate my thyroids actual production.

 

[Blown_SC]

All at once in the morning on empty stomach... works for me.

I would split it up, however, if taking higher dosages (over 100mcg/day, etc)...

 

[Trevdog]

Taking T3 on an empty stomach maximizes its absorbtion. So, I take it first thing in the am and don't split doses even if I'm using 100 mcg. ed.

 

[thee12nv]

My understanding is that its half life is like 36 hours so if that is the case there would be no reason to split the dose correct?

 

[brooklynheight]

My understanding is that its half life is like 36 hours so if that is the case there would be no reason to split the dose correct?

hmmm

http://www.mythyroid.com/drugs.html



Triiodothyronine or T3
T3 is derived from T4 by enzymatic conversion in the blood and peripheral tissues. T3 is the more active form of thyroid hormone, and binds to nuclear thyroid hormone receptors in different cells and tissues. In contrast to T4 which has a long half-life of several days, T3 has a short half life (hours), and disappears more rapidly from our blood after a single dose. Furthermore, T3 is much more potent, and if taken in excessive dosages, T3 may rapidly cause problems such as fast heart beats and palpitations, increased sweating or anxiety, increased blood pressure, and in some patients, even chest pain (angina). T3 is often used for a brief period of time following thyroid surgery for thyroid cancer, following which the T3 is discontinued prior to administration of radioactive iodine. There are some reports suggesting that patients with hypothyroidism treated with T3 alone, or T3 in combination with T4 feel better and may experience less depression than patients treated with thyroxine alone. Only a few small studies have been carried out to examine this issue, and more information and larger studies are clearly warranted to examine the risks and benefits of T3 administration, as reviewed in Optimal Thyroid Hormone Replacement.

other source

The metabolic effectiveness of T4 is decreased by agents that inhibit T3 formation, indicating that much of the T4 activity stems from formation of T3. This is further supported by the differences in TBG binding affinity and half-life. T4 has a half-life of 6.7 days while T3 has a half-life in serum of only 1.5 days. It has become apparent in recent years that T3 plays an important role in the maintenance of the euthyroid state.