Will Nolvadex(Tamoxifen) block DHT as good as Propecia
- Thread starter diesel69
- Start date
HUGE.HULK
New member
Your doc should go back to med school.
you MUST have misunderstood.
Nolva (tamoxifen) has no negative effect on DHT - on the contrary - it will block the effect of estrogen in some tissues and RAISE your testosterone levels resulting in additional DHT conversion. So, take tamoxifen and you'll get extra hair loss.
On the other hand I am not a fan of Propecia - in theory it only blocks the action of DHT in some tissues - (types I and II of isoenzymes 5alpha-reductase) and also in theory it RAISES testosterone levels (by allowing less to be converted to DHT or by signalling the body there's not enough DHT ?? don't know this answer)
but in practice (I took it for years) a.) it stopped my hair loss as per personal observation and b.) it drastically lowered test levels and only tamoxifen therapy (with some exemestane) finally reversed it.
so... suck it up and lose the hair .. if it's going to happen it's going to happen
Nolva (tamoxifen) has no negative effect on DHT - on the contrary - it will block the effect of estrogen in some tissues and RAISE your testosterone levels resulting in additional DHT conversion. So, take tamoxifen and you'll get extra hair loss.
On the other hand I am not a fan of Propecia - in theory it only blocks the action of DHT in some tissues - (types I and II of isoenzymes 5alpha-reductase) and also in theory it RAISES testosterone levels (by allowing less to be converted to DHT or by signalling the body there's not enough DHT ?? don't know this answer)
but in practice (I took it for years) a.) it stopped my hair loss as per personal observation and b.) it drastically lowered test levels and only tamoxifen therapy (with some exemestane) finally reversed it.
so... suck it up and lose the hair .. if it's going to happen it's going to happen
really ?? tell me ... which part ???
still waiting for scarz but
In the meantime ... FINASTERIDE (Proscar) does indeed bind (ie. attach) to the 5-alpha-reductase enzyme (basically a protein) which is responsible for the conversion of testosterone into DHT.
Finasteride is an irreversible inhibitor which has a complementary shape to that of the active site of the 5-alpha-reductase (in other words, it has a similar shape to the substrate) --- which means that it will compete with the substrate for the enzyme.
5-Alpha-reductase exists as two isoenzymes Type 1 and Type 2. Finasteride inhibits Type 1 (selectively - although I have BIG doubts about the full selectivity) and Dudasteride inhibits BOTH.
Finasteride reduce serum levels of DHT by about 70% (like Mr10X says) and Dudasteride by 90%+.
By binding (finasteride that is) with the 5-alpha-reductase serum testosterone levels will go UP and so will ESTROGEN levels (in theory and according to most clinical studies).
If you read the prospect it will tell you that you might experience libido problems, as well as lower sperm and gynomastia.
All for a little bit of extra hair. I took it and it fu...d me up. Retention of water, loss of definition, loss of libido, lower spermagenesis and changes in thyroid hormone production, and, in my case LOWER testosterone levels (probably because of the thyroid change) .... and oh yeah, my hair stopped falling.
Sure others will NOT experience these problems - but - if you do, just remember it was on the prospect the whole time.
In the meantime ... FINASTERIDE (Proscar) does indeed bind (ie. attach) to the 5-alpha-reductase enzyme (basically a protein) which is responsible for the conversion of testosterone into DHT.
Finasteride is an irreversible inhibitor which has a complementary shape to that of the active site of the 5-alpha-reductase (in other words, it has a similar shape to the substrate) --- which means that it will compete with the substrate for the enzyme.
5-Alpha-reductase exists as two isoenzymes Type 1 and Type 2. Finasteride inhibits Type 1 (selectively - although I have BIG doubts about the full selectivity) and Dudasteride inhibits BOTH.
Finasteride reduce serum levels of DHT by about 70% (like Mr10X says) and Dudasteride by 90%+.
By binding (finasteride that is) with the 5-alpha-reductase serum testosterone levels will go UP and so will ESTROGEN levels (in theory and according to most clinical studies).
If you read the prospect it will tell you that you might experience libido problems, as well as lower sperm and gynomastia.
All for a little bit of extra hair. I took it and it fu...d me up. Retention of water, loss of definition, loss of libido, lower spermagenesis and changes in thyroid hormone production, and, in my case LOWER testosterone levels (probably because of the thyroid change) .... and oh yeah, my hair stopped falling.
Sure others will NOT experience these problems - but - if you do, just remember it was on the prospect the whole time.
Last edited:
Similar threads
