Adding a methyl group to a steroid
- Thread starter Clamp
- Start date
That is organic chemistry. It is doubtful that you would be able to selectively methylate a compound without some serious know-how and even more serious chemicals, and the most serious equipment. You cant just stick a methyl group anywhere on a molecule and get what you want.
Clamp
New member
I know where to place it, I just have no idea how.
There are instructions and journals on the synthesis of some steroids in the journal of organic chemistry but unfortunately I don't have a subscription.
Do you know anything about racemic mixtures, chirality, or enantiomers? When you dump a few uncontrolled reagents into a bowl without controlled environmental factors, you are likely to come up with something that is not for which you planned. Biochemical hormones are notorious for requiring a certain "handedness." You would likely need a stereospecific reagent to get what you wanted.
kataklysum
New member
Just buy some methyltrienolone. That's what I did. Easy as
Clamp
New member
Here's what I know I need to do to get tren to methyltrienelone-
"convert tren to the 3-oxime with hydroxylamine hydrochloride in pyridine
conversion to the 17-ketone by oppenauer oxidation
grignard reaction to make make the 17a-methyl,17b-OH
removal of oxime protecting group"
-Patrick Arnold's recipe
I've figured out how to do one and two so far, I'm still researching how to perform steps 3 & 4. Since you're so great with organic chemistry why don't you share some wisdom?
"convert tren to the 3-oxime with hydroxylamine hydrochloride in pyridine
conversion to the 17-ketone by oppenauer oxidation
grignard reaction to make make the 17a-methyl,17b-OH
removal of oxime protecting group"
-Patrick Arnold's recipe
I've figured out how to do one and two so far, I'm still researching how to perform steps 3 & 4. Since you're so great with organic chemistry why don't you share some wisdom?
Clamp
New member
I would but my supplier sells a minimum of 10 grams of powder even for expensive ones and methyltrienelone is about 40 bucks a gram. I won't ever need that much and I don't need to pay that much either. Plus I like to learn about these things and I learn by doing things.
Needtogetaas
New member
just get the book bro.
Clamp
New member
Journal of organic chemistry. There are articles in there about synthesizing other steroids like methasterone (superdrol) from anadrol and info going all the back to the early 1900's. If there's a place that'll have an article on it, that'd be it.
I have someone that has access through a hospital, I can't access myself, so I'd need a specific journal issue or article reference as I can't ask this person to sift through articles while on the job. Any specific issues or articles you need? I've got some old chem texts laying around as well I'll see if I can find info in them
Clamp
New member
I already have. He posted a recipe to make it from tren ace back in March, 1997 but I can't find his original recipe even after searching for an hour straight.
JimiThing
Moderator
I will pm him for you on another forum where I interact with him, let you know what he has to say but since his legal issues he is a bit funny about answering these types of questions. Ill let you know.
Clamp
New member
Thanks man, I never thought I'd be able to contact the cook directly- I was just hoping to duplicate his recipe. Looking forward to your response
Step 3: You must conduct the reaction in an inert gas/air free environment. Grignard reagents are extremely sensitive moisture. You must use tetrahydrofuran (diethyl ether may be problematic as it can be used to make other illegal products that LE is more inclined to follow). I wouldn't go the Grignard route. An Sn2 reaction after proper preparation would likely give a lower yield, but it would be an easier home brew. It would require less know how and more readily available reagents. Grignard can be explosive. So, ATF alert there.
Step 4: Removal of a protecting group with commercially available products typically ends with shitty yields. The best chemists get 75%. Most protecting groups can be eliminated via acids or oxidation (which you cant use for this prep)
I am not trying to be an ass. I know I may have come off that way, but stereospecific addition of CH3 is difficult for a home brew. Plus, you wouldn't know what you had unless you knew everything about the finished product--melting points, solubility, and a hundred other things. You would need to use IR spectroscopy or an NMR to determine for sure.
It is such a dangerous compound, and getting to the point of having a dangerous compound could be hazardous as well...physically, and legally. I am not trying to be your dad, but I don't see the value in it. Not that your values are mine, but while it is doable, is it worth it? There wont be a trumpet and cloud splitting sunlight shining on the finished product--it will just be some residue that you won't likely know its constituency.
I cannot help any further, but wish you the best of luck.
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