I know it is an old thread but maybe the information will help someone else... Anxiety *IS* a side-effect of Aromasin/Exemestane. Not in all people of course, but it is a documented side-effect. Check out information on adverse effects from Mayo Clinic - don't just take my word for it. I do get a minor amount of anxiety the first few days I take it when I kick off a cycle but it subsides fairly quickly. If it doesn't subside then you may want to consider an alternative. If you try Letro instead, do not take a full dose. It will eradicate over 95% of the E in your body which often leads to joint problems. Like it or not, estrogen is vital for maintaining healthy, functional joints. Hard to get a pump on when your joints are thrashed.