Athrophy a persistent issue with my TRT

one way step

one way step

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I have been on TRT for about 11 years. My routine at the moment is 200mg test cyp per week plus .5mg cialis daily. I also usually take amiridex (0.25mg) every week or every other week.

For a while now I have been having a bad problem with testicular athrophy. It seems like it's been really bad the past year or so. The daily Cialis helped with the problem a little bit when I first started taking it daily but it seems to slow down.

The issue I have is that I appear to have gotten desensitized to HCG. It doesn't help my athrophy anymore nor give me any other benefit, and seems to cause a lot of water retention. Before this arbitrary desensitation happened, HCG worked great. It improved athrophy instantly and gave a great boost to my sex drive and erection frequency.

With that, I'm not sure what to do about this athrophy. It is pretty significant and it looks like I just came out of swimming in the Arctic Ocean.

Any ideas? Suggestions?
 
HCG causing a Spike in Estrogen is Common.
So you usually will need to Increase the Frequency of your AI to combat this.
What was your Dose and Frequency on the HCG ~ 250 IU's Twice a Week or more........................ JP
 
My sweet spot routine would be taking 500iu HCG once per week. Typically, I would take 500iu HCG and .25mg arimidex on a Wednesday and then 200mg test on Thursday. This had me feeling like a million bucks.

I've tried split doses with more frequency (ex 100mg test 2x per week, 250iu HCG 2x) but that had me feeling incredibly lousy.

Like I mentioned, the HCG for whatever reason doesn't work anymore. I don't get any results from it except for negative side effects. I believe I got desenstized to it. Another thing to note is that this HCG issue took effect after I stopped taking a medicine called gabapentin, which I had to stop abruptly and caused a world wind of terrible other problems for me. But that's a problem for another time.
 
Is your HCG legit ? There is a chance it is not potent or legit if your not getting Pharm. Grade HCG. I would suggest 500 IU 2x per week and see how that goes.

You need an ultra sensitive E2 test to figure out if you need more or less arimidex. My gut says it is probably higher than you think.
 
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Yes my HCG is from my local CVS pharmacy and is the same brand I've been using for years (APP). I've also tried novarel to see if that would fix anything but no luck.
 
Do you have any recent labs, so you are not playing a guessing game with your E2?

The recommended dose for atophy of guys on TRT over 40 years of age, is 500 IU 2x per week (1000 IU total per week)
 
Test: 648 ng/dl (range 348-1197)
Estradiol: 33.2 pg/nl (range 7.6-42)
Estrone, Serum: 82 pg/nl (range 12-72) high

Even with these numbers, it seems like anytime I take my AI (at 0.25mg) it seems to make my sex drive worse.

For note, I am 29 years old.
 
I pin once per week.

I've broken it up in the past (100mg 2x per week) and have not gotten good results. I feel much better pinning once per week.
 
I do not want to get too personal, but if my math is correct, and you are 29, on TRT for 11 years?? You started TRT at 18?? Do you have underlying medical issues?
 
I am hypogonadal and received high dose test shots to get through puberty. Been on trt since age 17 once that was done, so I guess it has been 12 years now.
 
Did they give you HGH along with Testosterone ? Did you mature and grow normally? Bone density, growth plates etc.? Did the doctors figure out why you are hypogonadal?
 
Have you ever tried a restart as a mature adult? There is a chance your atrophy issues and other things could fall back into place if your HPTA was functioning normally.
 
I apm sorry to hear your a lifer at such a young age. However, at least you have options, and a lot of great information and knowledge from the guys on here.
 
Thanks man. It sucks but things can be worse.

One of the other problems I've had since no longer using HCG is my longevity, for lack of a better word. When taking HCG, I would last forever in bed and be rock hard. Now without HCG, it seems like I end things a lot quicker than I want to. It seems like I'm much more sensitive down there. I last like one minute. That's another real shitty problem I have with this HCG desensitization.
 
I am not an expert on what I am going to suggest, but I have seen it mentioned by others with TRT. Taking clomaphine while on TRT can possibly be beneficial with what you are going through. I am NOT talking about a restart. Maybe someone else can help us out here...???
 
Yea I didn't have much luck initially with clomid, but I still have my prescription and am always willing to retry things to see if it can improve my situation.
 
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