Apparently here is a cheap substitute.
Very interesting read..
Vitamin B6 is a surprisingly effective prolactin inhibitor that is extremely cheap and safe: One human study showed a single 300mg dosage of B6 exerts ***8216;a hypothalamic dopaminergic effect***8217; which causes a ***8216;significant decrease of plasma prolactin***8217;(1);
Another found that 300mg of B6 taken twice a day by 10 normal women lowered prolactin levels and slightly but significantly raised growth hormone levels. The authors concluded: ***8216;The effect of vitamin B6 is likely to be mediated by dopaminergic receptors at hypothalamic level***8217;(2);
Another study found B6 to significantly reduce ***8216;opioids-induced hyperprolactinemia***8217;(3);
This study on men found that ***8216;Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise***8217;(4);
And a study on male rats found that, ***8216;Pyridoxine hydrochloride significantly suppressed the chlorpromazine-induced prolactin rise (p less than 0.01). However, the suppression was significantly less than that produced by bromocriptine (p less than 0.01)***8217;(5).
Clin Endocrinol Metab 1976 Mar;42(3):603-6
Effect of pyridoxine on human hypophyseal trophic hormone release: a possible stimulation of hypothalamic dopaminergic pathway.
Delitala G, Masala A, Alagna S, Devilla L.
A single dose of pyridoxine (300 mg iv) produced significant rises in peak levels of immunoreactive growth hormone GH and significant decrease of plasma prolactin PRL in 8 hospitalized healthy subjects. Serum glucose, luteinizing hormone LH, follicle stimulating hormone FSH and thyrotropin TSH were not altered significantly. In addition, in 5 acromegalic patients who were studied with both L-dopa and pyridoxine, inhibition of GH secretion followed either agent in a similar pattern. These data suggest a hypothalamic dopaminergic effect of pyridoxine.
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N Engl J Med 1982 Aug 12;307(7):444-5
Pyridoxine (B6) suppresses the rise in prolactin and increases the rise in growth hormone induced by exercise.
Moretti C, Fabbri A, Gnessi L, Bonifacio V, Fraioli F, Isidori A.
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Boll Soc Ital Biol Sper 1984 Feb 28;60(2):273-8
[Influence of administration of pyridoxine on circadian rhythm of plasma ACTH, cortisol prolactin and somatotropin in normal subjects]
[Article in Italian]
Barletta C, Sellini M, Bartoli A, Bigi C, Buzzetti R, Giovannini C.
The influence of vitamin B6 in a dosage of 300 mg X 2 in 24 hrs, on circadian rhythm of plasmatic ACTH, cortisol, prolactin and somatotropin have been studied in 10 normal women. After vitamin B6 24 hrs pattern of ACTH and cortisol is unchanged; prolactin levels are slightly lower, in a statistically unsignificant proportion the night peak of growth hormone is higher in a statistically significant proportion (p. 0.05). The effect of vitamin B6 is likely to me mediated by dopaminergic receptors at hypothalamic level as previous studies by other Authors appear to prove.
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