Same directions if you buy the cap-m-quick 50 cap machine also.
THANKS TO BASSKILLERONLINE
1. Load 24 empty caps into the capsule machine, then fill all 24 caps with Baking Soda (tamping powder if final caps will be tamped).
2. Empty all the Baking Soda out of the capsule machine and weigh it. Total weight = 17,160mg
3. Divide that weight (17,160mg) by the number of capsules (24) to get the total weight per cap. 17,160mg / 24 = 715mg a cap.
4. Repeat these steps with the Aspirin powder. Total weight = 11,760mg / 24 = 490mg a cap.
5. Now we need to figure out the ratio of Aspirin to Baking Soda.
100mg Aspirin = Unknown mg of Baking Soda
490mg Aspirin = 715mg Baking Soda
(100mg Aspirin x 715mg Baking Soda) / 490mg Aspirin = 146mg of Baking Soda (this is the Unknown mg of Baking Soda, and how much must be removed to make space for 100mg of Aspirin)
715mg Baking Soda - 146mg = 569mg Baking Soda (this is how much Baking Soda to use per cap)
569mg Baking Soda x 48 caps = 27,312mg Baking Soda
100mg Aspirin x 48 caps = 4800mg Aspirin
So to make 48 100mg Aspirin caps we need 4800mg of Aspirin powder and 27,312mg of Baking Soda.
This is where the simpler methods fail and give inaccurate results. As the chart below shows, different compounds (like Aspirin and Baking Soda (Sodium Bicarbonate)) weigh different amounts for the same volume. If we had simply subtracted 100mg from the Baking Soda we would not have had properly dosed caps, because to fit in 100mg of Aspirin we needed to subtract 146mg of Baking Soda.
Now that we know how much active compound and filler to use (Aspirin and Baking Soda) we need to mix them together. To do this we'll use a mortar and pestle with the geometric dilution method, which was introduced to me by pharmguy24 on AU. What's the geometric dilution method you ask? It's a method used when a small amount of powder needs to be *thoroughly* mixed with a larger amount of powder. To do this you mix all of the smaller powder with an approximately equal amount of the larger powder, this blend is called "mix 1". Then combine all of your "mix 1" with an equal amount of the larger powder and blend again, this is "mix 2". Keep going like this until all the powders have been mixed together.
So we place all of the Aspirin powder (the smaller amount of the two different powders) in the mortar and add an equal amount of the Baking Soda (approximately 4800mg), then blend them together with the pestle for a couple of minutes. This combination is our mix 1, and it is now 9600mg (4800mg Aspirin + 4800mg Baking Soda). After it's been blended for a few minutes add an equal amount of Baking Soda (9800mg) to your mix 1 and blend for a couple more minutes. This combination is our mix 2 and is 19,200mg (9800mg from mix 1 + 9800mg Baking Soda). After it's been blended for a few minutes add the remaining Baking Soda (12912mg) to your mix 2 and blend for a couple more minutes.
Why go to this extra trouble? Because even though we know the amounts of Aspirin and Baking Soda we're using are dead on, our caps will not be dosed properly if the powders are not mixed together very thoroughly.
