Creatine works well for pretty much everyone, but the non-responders. To answer your qurestion, the answer is absolutely YES, you should use it on cycle...and off-cycle. There is no reason to ever go off. It is so damn cheap that anyone can afford to use it permanently. For a natural supplement, it is actually quite amazing. Most guys, if either a first time user or if the person hasn't used it in a while, will add between 4-8 lbs if bodyweigh. This weight is primarily I.M water, which looks exactly like muscle...and usually a smaller amount of sub-q water, although you can significantly cut down on sub-q water retention by using an ultra-micronized version of creatine, such as ultra-micronized creatine monohydrate. A 20 lbs gain on all your basic lifts in about 4 weeks is common. Muscular endurance will also increase substantially. Creatine is a supplement every BB'r should be using...alll the time. A small percentage of users are non-responders...because their body already produces enough creatine to saturate muscle cells, so additional creatine has no effect. You probably aren;t one of these people. Any supplement that only costs $5/month and makes you look visibly bigger and significantly stronger in just 4 weeks, is a no-brainer purchase.