Curious about others experiences with low E

[swilk]

Long story as short as possible ...

Protocol leading up to bloods 12 weeks ago:

70mg test C every 3.5 days. 250iu of HCG every 3.5 days same day as test injection.

Results of blood work 12 weeks ago: TT 737 (348-1197). Free T 36.56 Free T (5-21) % 4.96 (1.5 - 4.2). Estradiol Sensitive 47

I decided to add .25mg of adex twice per week ....

I also decided to drop the HCG just to see if I could feel any difference between being on it and being off it while at the same time increasing my test dose to 80mg twice per week.

Bloods last week showed TT 886. Free T 35.35. Free T % 3.99 Estradiol Sensitive 9

I know that 9 is to low but I dont feel anything from it. I am finally to a point of getting nigh time erections pretty regularly and I fell better the best so far while on TRT. I still think I might be a little more tired than I should be at times but nothing like before.

So ... from 50 down to 9 with not a lot of difference in the two?? at 50 I had what i thought to be more oily skin from time to time but nothing major.

BWT .. I am cutting my adex does in half and taking .25mg one time per week instead of two.

Just curious about others experiences on the estradiol roller coaster ....

 

[3J]

i run at about 25 on the normal test taking 100mg twice a week and 1/2mg adex twice a week..

but recently i have noticed lower estrogen levels.. i have to do a blood test to see exactly whats going on..

 

[Alpin]

Adex should be dosed no more than E3D. You will get a rebound effect with once a week.
I would dose 0.125 mg eod-e3d instead.

 

[swilk]

For the sake of conversation .... what kind of rebound effect will I feel if I didnt notice any difference going from nearly 50 down to 9?

I would do the .125mg e3d but I have pills ... and cutting them into 1/8's will equal a pile of dust instead of a pill.

If the answer to my first question seems worth it I can make a more determined attempt to do the whole cut into 1/8's thing.

 

[Mprtz]

The term "rebound effect" has been used repeatedly in the context of AI and E2.
Rebound effect is when a medication produces an effect and the discontinuation of that medication causes the opposite effect because the body is compensating for the effect of the medication in some way.

A typical example is headache medications that work by constricting blood vessels. Often these medications will appear to cause a headache when they wear off because blood vessels may dilate past the point where the medication was taken.

To be a rebound effect, there would have to be a mechanism that causes the body to compensate for AI with elevated production of aromatase enzyme. I would be interested in any references showing that this happens.

 

[swilk]

BTW ... for anyone doing subq and cares about some feedback ....

Originally I had 4 injection sites and would rotate each injection. Right of belly button, right thigh, left of belly button, left thigh.

I didnt have much problem with the belly injections but I was getting stinging injections from time to time so I decided to abandon them and do hihg/low injections on each thigh.

Now my 4 sites in the rotation are left thigh high, left thigh low .... right side high and low.

I like it much better.

With the exception of one minor bruise I have had zero problems doing it this way for the past 12 weeks.