100mg i would say no prob, but it really depends on how many supplement you are taking combined. There was a story on tv about a yr ago and a woman was taking mega dosages and with other pills. What happened is that her liver couldn't process all the pill so it went into a cell degeneration in the liver and she became very fatuiged, nausea till she fell asleep on the couch and went into a coma. Someone found her and she was rushed to the ER and by that time her liver was infected and since it could not function the infection went systemic and went into her bloodstream and shutting down her renal systems. Too late to do anything. I would try to minimize dosage. Imo, 150mg is not necessary. Not saying this will happen to you, but it really depends on how much combined with other supplements.