Doc won't allow HCG and AI use

I've been running HCG - 10 weeks on @ 500iu every 3.5 days and then taking 4 weeks off...

It's a protocol that a well respected old forum member recommended (riprockwell)

Do you think there is anything good to gain from doing this?
Or would you recommend I just stay on year round?

BTW: My TRT protocol is Nebido (Test Undecanoate) @ 1000mg/4ml every 4 weeks along with 0.5mg Adex E5D
 
I'm perfectly calm dude. Pacifism is not something to hide behind.


its all water under the bridge.
 
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Regardless of what you've learned from him, I don't agree with the scaremongering he's done about HCG since his return a couple of days ago. While I may have been confrontational, I do not think I've been in any way disrespectful. Pointing out someone's potential conflicts of interest when then have a product or service they are selling is a vital part of any discourse. I do not believe I've impuned his integrity in any way. If you are selling something, you have the natural incentive to sing its praises. If you think pointing that out and questioning someone when they make unsupported claims about risks of not using what they are selling is disrespectful than you have awfully thin skin.




Why are you such a bully when people don't agree with you, or question you?

It is the way you did it. Let's go back and look at some of what you wrote.

I'm a skeptic by nature, but it just doesn't sit right with me that a guy selling HCG is making some scary claims about what will happen if you don't take HCG without any proof. If you have data publish a study, if not don't go around implying that people will have a heart attack if they don't use your product. Thats just FUD.

If you have the data publish the data. Don't act all indignant when someone calls you out for making unsupported claims. That just makes me think you are full of shit. I don't know one way or the other, I'm new to all this. Educate me.

I said that by saying you might have a heart attack if you don't take HCG, without anything more than conjecture to back that up, he's spreading Fear, Uncertainty and Doubt (FUD), a common tactic when somebody is selling something.

No "please". No "thank you". No, " Hey, I find this interesting. I would like to learn more. Would you mind telling me more and posting a study or two..."

You could have asked in a much nicer manner. Instead you were very quick to jump on Det-Oak. And at the same time, you referenced things you had heard but you didn't share/provide any contradicting information. You have yet to post a study of your own. You yourself have admitted that you know very little about TRT, but at the same time you are trying to call bullshit on a guy.

Please think about your approach. Again, we are all here to learn from each other and help each other. That is what makes this such a great forum. There are ways to make your point without personally attacking someone. For exanple, you didn't have to acuse me of having thin skin and make this personal, but you chose to.
 
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I've been running HCG - 10 weeks on @ 500iu every 3.5 days and then taking 4 weeks off...

It's a protocol that a well respected old forum member recommended (riprockwell)

Do you think there is anything good to gain from doing this?
Or would you recommend I just stay on year round?

BTW: My TRT protocol is Nebido (Test Undecanoate) @ 1000mg/4ml every 4 weeks along with 0.5mg Adex E5D

Rip knows his stuff for sure.

Nothing wrong with a break from HCG every now and then.
 
It is the way you did it. Let's go back and look at some of what you wrote.







No "please". No "thank you". No, " Hey, I find this interesting. I would like to learn more. Would you mind telling me more and posting a study or two..."

You could have asked in a much nicer manner. Instead you were very quick to jump on Det-Oak. And at the same time, you referenced things you had heard but you didn't share/provide any contradicting information. You have yet to post a study of your own. You yourself have admitted that you know very little about TRT, but at the same time you are trying to call bullshit on a guy.

Please think about your approach. Again, we are all here to learn from each other and help each other. That is what makes this such a great forum. There are ways to make your point without personally attacking someone. For example, you didn't have to acuse me of having thin skin and make this personal, but you chose to.


I may not know a lot about TRT but I know a ton about sales. I know when someone is talking their book and I call it like I see it. That was the first time I've seen that here and I was surprised by it. Confrontational, sure, disrespectful? I dont' think so. I'll be more careful not to hurt any ones feelings from now on.

Edit: you both have it backwards, I'm not the one making claims, I'm the one calling out claims that I haven't seen any scientific support for. So there is no onus on me to provide data, I'm not trying to prove anything. If you make a claim like "Not taking HCG when on TRT can cause hardening of the arteries, you should be prepared to back that claim up with data, not the other way around. That is akin to asking someone to prove a negative, its logically impossible.
 
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This is more rhetorical than anything. How ironic is it that someone named trtnooby is gonna come on and call out someone with loads of experience. Probably more than most GPs. It hurts my head. It's almost as much a guarantee as when some douche corrects grammar online. Always fucks up grammar or spelling when doing so.

I run HCG regularly 2x week at 375iu because of the benefits already outlined as well as my suspicion that it preserves some hormone cascades we don't fully understand yet.

I would recommend the following to noob:
Listen, be polite, and be diplomatic when something is said that doesn't sound right or jive. I just had a similar experience where I asked Det Oak to clarify a recommendation. He was very cool about the response and admitted he overlooked some info in my bloodwork. I doubt he would have extended the kindness if I was an asshole. Good life rule to follow too fwiw.

Good luck with your trt journey
 
Well this train derailed.

OP - My first few months were without AI's or hCG, and honestly it wasn't quite the same without them. I honestly can say I've felt ALOT better on them... and being able to keep my stupid Estradiol in check instead of it running crazy making me an emotional girly man with peanut sized nuggets is defiantly a plus.

If you can find a way I would pursue it. If not that's OK, it wont kill ya but it may not be optimal.

Think about it like eating a nice big steak, without a baked potato. You still got steak, but it could be better.

-> IMO <-
 
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I may not know a lot about TRT but I know a ton about sales. I know when someone is talking their book and I call it like I see it. That was the first time I've seen that here and I was surprised by it. Confrontational, sure, disrespectful? I dont' think so. I'll be more careful not to hurt any ones feelings from now on.

Edit: you both have it backwards, I'm not the one making claims, I'm the one calling out claims that I haven't seen any scientific support for. So there is no onus on me to provide data, I'm not trying to prove anything. If you make a claim like "Not taking HCG when on TRT can cause hardening of the arteries, you should be prepared to back that claim up with data, not the other way around. That is akin to asking someone to prove a negative, its logically impossible.

TRTnooby: I have tried asking you twice now to be respectful of others in this forum and you came out swinging both times. Now I am telling you to knock it off. Learn how to play nicely with others here. I have no desire to give you a "time out" but I will if you keep this up. I truly hope that you choose to remain here and make positive contributions to the forum. You can challenge people all you want, but find a way to do it in a respectful manner. Please keep asking questions too, but in a respectful manner.
 
I have been on Testosterone shots and AI for over a year now. I can vouch that after using HCG for two months, that sex feels better; there is more volume; and my nuts don't pain anymore. There are other benefits, but those are the big ones.
 
That actually doesn't sound bad tbh. The wife has been trying to get a 3rd kid out of me and I've been resisting. Guess I'll find out in 8 months.



It was 32 the morning of my next shot, 3.5 days since my last one. I've since moved to E3D since that blood work, so my next one will be 3d since a shot. I'd been taking the zinc and DIM for 4 weeks. My next blood work is in February.



Yes 49 was at Trough, which is why I started taking the Zinc and DIM, I wanted to try that before an AI since I didn't have any symptoms of high E2. I took that for 4 weeks and my most recent blood work last month it was down to 32, still no symptoms of high E2 so far so good.

So you went from 49 to 32 pg/ml trough?
(Day of shot but BEFORE shot?)
all with 50 mg ED zinc ?? How much DIM ?
Interesting....could be your body adjusting to the meds too. ..
no way knowing for sure if its either/or (zinc/DIM)
I imagine its not hurting much.
 
Yes but by then the leydig cells will be so desensitized it will take high dosages for long periods of time to get them back to function, leaving you susceptible to estrogen side effects.

Only a few reasons to not take HCG with your TRT, and these are extremely rare.

How bad would u say it is DET, if you dont jump on the right dose of HCG from the get go on a TRT protocol(for sake of dialing in)?
I know guys with more primary hypo won't get much benefit from 250 i.u shots 2 times a week let alone see any maintenance in ball size/sperm count.
 
Good luck with your trt journey


Thanks!

TRTnooby: I have tried asking you twice now to be respectful of others in this forum and you came out swinging both times. Now I am telling you to knock it off. Learn how to play nicely with others here. I have no desire to give you a "time out" but I will if you keep this up. I truly hope that you choose to remain here and make positive contributions to the forum. You can challenge people all you want, but find a way to do it in a respectful manner. Please keep asking questions too, but in a respectful manner.

Ok, no problem.

Let me ask you this. You posted many times here that it was fine for men on TRT not to be taking HCG, and that there were pluses and minuses to using it. AFAIK the main positives are that it increases ball size and semen volume, as well as back filling the HPTA, the main negative is that it makes E2 harder to manage. That is a lot to weigh and I've been back and forth in my head many times about it. I don't have to take an AI now, and I really don't want to if I can avoid it.

You yourself I think only started using it recently after many years of not. It was on that basis that I began my treatment with just T, trying to dial that in first, while evaluating weather or not to add HCG later. It just made sense to me to be conservative with what I put in my body, and only add one thing at a time to see how I react.

DET OAK has posted that he thinks its a huge mistake to do that and I should be on HCG immediately, to not be on it is taking big risks with my health. My arteries might harden, my leydig cells will be extremely desensitized and it will take months or years to bring them back.

What do you think am I making a huge mistake waiting?

I have been on Testosterone shots and AI for over a year now. I can vouch that after using HCG for two months, that sex feels better; there is more volume; and my nuts don't pain anymore. There are other benefits, but those are the big ones.

So you were not using HCG for a year while using T, then you started using it, how long did it take before you noticed a difference? I've noticed a decrease in semen volume but no decrease in feeling or any pain


So you went from 49 to 32 pg/ml trough?
(Day of shot but BEFORE shot?)
all with 50 mg ED zinc ?? How much DIM ?
Interesting....could be your body adjusting to the meds too. ..
no way knowing for sure if its either/or (zinc/DIM)
I imagine its not hurting much.

Yes both times blood was taken day of but before the shot, over 4 weeks of using 50mg zinc picolinate and 100mg of DIM my E2 went from 49 to 32 (non sensitive test). I have no idea how much effect the zinc and dim had with it and how much is just my body adjusting. I'll test again in February and post the results.
 
Let me ask you this. You posted many times here that it was fine for men on TRT not to be taking HCG, and that there were pluses and minuses to using it. AFAIK the main positives are that it increases ball size and semen volume, as well as back filling the HPTA, the main negative is that it makes E2 harder to manage. That is a lot to weigh and I've been back and forth in my head many times about it. I don't have to take an AI now, and I really don't want to if I can avoid it.

You yourself I think only started using it recently after many years of not. It was on that basis that I began my treatment with just T, trying to dial that in first, while evaluating weather or not to add HCG later. It just made sense to me to be conservative with what I put in my body, and only add one thing at a time to see how I react.

DET OAK has posted that he thinks its a huge mistake to do that and I should be on HCG immediately, to not be on it is taking big risks with my health. My arteries might harden, my leydig cells will be extremely desensitized and it will take months or years to bring them back.

What do you think am I making a huge mistake waiting?



So you were not using HCG for a year while using T, then you started using it, how long did it take before you noticed a difference? I've noticed a decrease in semen volume but no decrease in feeling or any pain

Unfortunately there is no definitive answer when it comes to taking hCG while on TRT. You are not going to find a longterm medical study where hCG was used on men. At least not one that I am aware of. For that matter, there aren't many, if any, longterm studies on men taking testosterone for TRT either. You will find studies that say TRT is good for men's health and studies that say it is bad for men's health. Many of the studies have flaws in them. Many only look at correlations rather than cause and effect. So somehow you are going to have to get past this uncertainty if you are going to continue TRT and/or consider hCG.

As you listed, some of the benefits to taking hCG while on TRT are:
- Maintaining fertility
- Limiting testicular atrophy
- Keeping the testicles functioning at a minimal level
- Testicles do more than produce more than testosterone. But honestly, I don't know if these other processes shut down in the presence of exogenous testosterone.
- Sexual benefits
- Many men anecdotally express that hCG gives them a" sense of well being."
- Probably many other benefits

Of course, there are potential downsides to taking hCG for long periods of time:
- Intra-testicular aromatization
- More complicated estradiol management
- Added cost
- More injections
- Unknown longterm effects
- Some men who are prone to anxiety or panic attacks seem to be affected by hCG.

I am not going to tell you that you are making a collosal mistake by not using hCG. I can share my personal experience though. I did not use it for a little more than two years while on TRT. While I knew the benefits, my doctor would not prescribe it to me. At some point along the way I decided to get some on my own and give it a try. I wrestled with this decision for a while and it wasn't one I took lightly. My testicles had gradually shrunk over time. My ejaculate volume had decreased. And I wanted to see if I too experienced that sense of well being. I have only been on it for a couple of months. I have noticed that my testicles have increased in size and sex is more enjoyable.

What I would recommend for you in particular at this point is to get dialed in on your current TRT protocol and then run with it for a little bit. Then at some point give hCG a try for three months and see what you think.
 
Unfortunately there is no definitive answer when it comes to taking hCG while on TRT. You are not going to find a longterm medical study where hCG was used on men. At least not one that I am aware of. For that matter, there aren't many, if any, longterm studies on men taking testosterone for TRT either. You will find studies that say TRT is good for men's health and studies that say it is bad for men's health. Many of the studies have flaws in them. Many only look at correlations rather than cause and effect. So somehow you are going to have to get past this uncertainty if you are going to continue TRT and/or consider hCG.

As you listed, some of the benefits to taking hCG while on TRT are:
- Maintaining fertility
- Limiting testicular atrophy
- Keeping the testicles functioning at a minimal level
- Testicles do more than produce more than testosterone. But honestly, I don't know if these other processes shut down in the presence of exogenous testosterone.
- Sexual benefits
- Many men anecdotally express that hCG gives them a" sense of well being."
- Probably many other benefits

Of course, there are potential downsides to taking hCG for long periods of time:
- Intra-testicular aromatization
- More complicated estradiol management
- Added cost
- More injections
- Unknown longterm effects
- Some men who are prone to anxiety or panic attacks seem to be affected by hCG.

I am not going to tell you that you are making a collosal mistake by not using hCG. I can share my personal experience though. I did not use it for a little more than two years while on TRT. While I knew the benefits, my doctor would not prescribe it to me. At some point along the way I decided to get some on my own and give it a try. I wrestled with this decision for a while and it wasn't one I took lightly. My testicles had gradually shrunk over time. My ejaculate volume had decreased. And I wanted to see if I too experienced that sense of well being. I have only been on it for a couple of months. I have noticed that my testicles have increased in size and sex is more enjoyable.

What I would recommend for you in particular at this point is to get dialed in on your current TRT protocol and then run with it for a little bit. Then at some point give hCG a try for three months and see what you think.

Cool that's been my thinking all along. Will continue with that plan.
 
I heard someone over was implying that using HCG desensitizes the testes? From what they have read?

Just thought I would stop by and clear that up xD

D'Agata R, Vicari E, Aliffi A, Maugeri G, Mongiol A, Gulizia S. Testicular Responsiveness to Chronic Human Chorionic Gonadotropin Administration in Hypogonadotropic Hypogonadism. J Clin Endocrinol Metab 1982;55(1):76-80.

Steroidogenic responsiveness to long term hCG administration (1500 U three times a week for 23 months) was characterized in 8 males with hypogonadotropic hypogonadism (HH). During hCG treatment, testosterone (T), which was in the prepuberal range under basal conditions, rose considerably to the upper end of the normal range and remained at that level during the 23 months of observation. A 2.5-fold increase was observed in serum levels of 17{beta}-estradiol (E2) an increment less than seen with T. The increment in 17{alpha}-hydroxyprogesterone was also lower than that in T throughout the study; thus, the 17{alpha}-hydroxyprogesterone to T ratio, despite continuous hCG administration, remained low. Serum androstenedione was slightly increased during hCG therapy. No significant changes were observed in serum levels of dehydroepiandrosterone. These data indicate that continuous long term hCG administration stimulated T levels in HH, with a relatively small change in E2. The kinetics of the T and E2 responses to 2000 U hCG, evaluated after 23 months of therapy, indicated that the testicular response was markedly reduced. No increment in T levels was observed at 24 h; the maximal response occurred at 48 h. This pattern of T response supports the idea that partial testicular desensitization occurs in HH patients receiving chronic treatment with hCG.
 
I heard someone over was implying that using HCG desensitizes the testes? From what they have read?

Just thought I would stop by and clear that up xD

Can you elaborate on the point you are making? The study you are quoting seems to support the notion of desensitization, but by saying you want to "clear that up", it sounds like you disagree...
 
The study does not support desensitization in any way shape or form. It clearly says that all 8 men remained in the upper end of the normal range for 23 months straight. and 1500 IU 3x a week! Thats a lot. 2 years is a long time too.

The desensitization they note is simply a delayed kinetic response to HCG administration from 24-48hrs. It obviously had no impact from a long term perspective.

We now know this is simply the refractory period due to the biphasic pattern of HCG.

Here is another:

Balducci R, Toscano V, Casilli D, Maroder M, Sciarra F, Boscherini B. Testicular responsiveness following chronic administration of hCG (1500 IU every six days) in untreated hypogonadotropic hypogonadism. Horm Metab Res 1987;19(5):216-21.

The observation that the testosterone (T) response to a single intramuscular injection of hCG is prolonged suggests that currently used regimens (2-3 injections per week) to stimulate endogenous androgen secretion in hypogonadotropic hypogonadism (HH) patients have to be reassessed. Moreover, during the last few years, Leydig cell steroidogenic desensitization has been found after massive doses of hCG. The aim of the present investigation, carried out in 6 HH patients who showed no signs of puberty, was to study the effect of 1500 IU hCG administered every six days over a period of one year to induce the onset of pubertal development. To evaluate the kinetics of the response of T, 17 alpha-hydroxyprogesterone (17 alpha-OHP) and 17 beta-oestradiol (E2), blood samples were taken basally and 1, 2, 4 and 6 days after drug injection. This dynamic study was performed after the first injection and after the 4th and 12th month of treatment. During this one year time period, a progressive increase in testicular size was observed. Comparing plasma T levels (mean +/- SE) before the first injection (11.2 +/- 4.7 ng/dl) with the corresponding values at the 4th (38.7 +/- 10.5 ng/dl) and 12th months (99.5 +/- 19.9 ng/dl) of therapy, a progressive and significant increase was observed. T reached a maximum elevation 58 hours after hCG injection at the 4th month (198.3 +/- 42 ng/dl; P less than 0.01) and at the 12th month (415.6 +/- 62.6 ng/dl; P less than 0.05), whereas it remained unchanged following the first hCG injection.(ABSTRACT TRUNCATED AT 250 WORDS)


^^^^ If you notice, T levels reached their highest point in the 12th month.

Hope this helps.
 
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Too bad on the lack of long term studies of either...
I found daily administration of HCG pretty potent on TRT...
I tried ED low dose of HCG at 100 i.u a day with my standard TRT dose 60 mg E3D. I noticed an increase in libido, well being, on the ED low dosage of HCG Vs. The dosing E3D at 350 i.u....
dont know what was what on estradiol etc with the ED low dosing. But seeing as HCG is biphasic....
Only God knows what it was doing.....lol
 
Too bad on the lack of long term studies of either...
I found daily administration of HCG pretty potent on TRT...
I tried ED low dose of HCG at 100 i.u a day with my standard TRT dose 60 mg E3D. I noticed an increase in libido, well being, on the ED low dosage of HCG Vs. The dosing E3D at 350 i.u....
dont know what was what on estradiol etc with the ED low dosing. But seeing as HCG is biphasic....
Only God knows what it was doing.....lol

What is the importance of HCG being biphasic? I'm not following you
 
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