Had a friend say that it caused him some anxiety, but I don't know how he can blame it on that when he is taking all kinds of stuff and never gets off. I've taken it before and it did not do anything to me. now I have had trouble with anxiety when I get off of a strong cycle and did not take the proper precautions with pct. I learned from that mistake! I ended up in the doctors office getting anti depresants for a while. I hope everyone knows by now to take post cycle therapy (pct), not only to help keep gains, but to also keep your emotions in check.