Fact sheet: AF's AIFM (Aromatase Inhibitor)

[simpllyhuge]

i wasnt implying it was expensive, i just figured if their was a discount i would use it. it looks pretty cheap to me. im also intrested in p seven, but not sure about using both at once.

 

[macro]

i wasnt implying it was expensive, i just figured if their was a discount i would use it. it looks pretty cheap to me. im also intrested in p seven, but not sure about using both at once.

they can be used simultaneously (different sites).

though you should try them separately so you can differentiate the effects

 

[Who is Mike Jones?]

Are there advantages to using this product if using prohormone cycles?

 

[macro]

Are there advantages to using this product if using prohormone cycles?

depends. a lot of the prohormones out now are progestins with quite odd/unknown metabolic pathways. depends on which ones.

 

[macro]

^^

 

[simpllyhuge]

for some one who doest come off. lets say i was always using a Aromatase inhibitor (AI) is it possible for my body to adjust, so that when i dont use an Aromatase inhibitor (AI) small amounts of test that the aromatization with affect me more?

 

[macro]

no. though using competitive inhibitors like letro and arimidex may have an upregulation effect short term.

 

[simpllyhuge]

can u explain in laymens terms please

 

[macro]

AIFM and aromasin are suicidal inhibitors, they bind to the enzyme "taking it out of the game" irreversibly, letro and dex are competitive inhibitors, the bind to the enzyme at a different site, the enzyme is still active, though not able to convert only while bound which is reversible as blood levels drop these enzymes are free to convert again. Also what you get is active enzyme floating around thats not doing its job but still may be binding to other co-factors and sites. This can lead to upregulation of aromatase enzyme production. though this is poorly understood (and could be due to a completely different mechanism that elucidated above) and has only been shown in vitro at this time. (though a number of Anabolic Androgenic Steroids (AAS) users report estrogen rebound with both letro and dex)

in vitro study

Clin Breast Cancer. 2000 Sep;1 Suppl 1:S68-73. Links
Comparison of in vitro exemestane activity versus other antiaromatase agents.Soudon J.
Pharmacell, Paris, France. pharm2@jupiter.chu-stlouis.fr

Anastrozole, letrozole, and exemestane are the most selective and potent oral antiaromatase agents currently available. However, in vitro and in vivo studies comparing these agents are lacking. Anastrozole and letrozole are reversible, competitive nonsteroidal type II inhibitors, whereas exemestane is an irreversible steroidal type I inactivator. The study was conducted to determine the impact of this characteristic on in vitro residual aromatase activity and protein levels after incubation of JEG-3 cells with aminoglutethimide (a type II inhibitor), anastrozole, exemestane, or letrozole. Aromatase activity was measured after various incubation times with each antiaromatase agent at a concentration 10 times higher than IC50 (concentration giving 50% inhibition). Only exemestane induced a residual inhibition of aromatase activity after its removal, without any change in the aromatase protein level. Aromatase activity increased after preincubation of JEG-3 cells with either aminoglutethimide or anastrozole without any change in the aromatase protein level. The aromatase protein level increased rapidly when cells were incubated with letrozole and aromatase activity inhibition disappeared immediately after removal of the drug. The breakthrough effects in aromatase activity or protein levels observed after treatment with reversible inhibitors may be a factor in therapeutic failure with these agents. These results suggest a possible advantage for exemestane because it is the only clinically available oral irreversible aromatase inactivator.

 

[macro]

^^

 

[simpllyhuge]

ok so i just got my aromasin i rubbed it hard in to my inner forearm and wrist. i hope it did it correct. how long does it have to stay on before i can shower?

 

[macro]

aromasin needs to be taken orally, though you may have purchased a liquid rather than tablet form it is still meant to be taken orally. AIFM is a topical/transdermal Aromatase inhibitor (AI). While they have similar action, both are suicidal inhibitors, their form of delivery/intake is quite different.

 

[simpllyhuge]

im sorry that was a typo i ment to say aifm. i definalty know the difference lol

how long does it take to get fully asborbed. does it happen through out the day or can i shower a few hours after use.

 

[macro]

its best applied after a shower (to clean skin), but you can shower within 2 hours of use.

ideally if applying twice a day, apply after AM shower and prior to bed

 

[simpllyhuge]

and its 1-3 squirts twice per day so 2-6 per day

 

[macro]

its very unlikely you will need more than 4 (on cycle), most people just use 2-3 pumps.

most people off cycle use 1-2 pumps per day.

 

[Parteeman]

One warning to the older, delicate-jointed among us: Too much AIFM, particularly in a test-only cycle, will dry out your joints. I have a bad shoulder, and 200 mg/week of cyp plus four squirts of AIFM a day (trying to get rid of gyno) did in my shoulder in a bad way. Probably as a result of driving E too low. Just my experience, but it makes sense. Very powerful stuff.

 

[macro]

AGREE.... just like with any Aromatase inhibitor (AI), too much estrogen suppression is not what you want.

1-2 pumps per day is a typical dose for people on Hormone Replacement Therapy (HRT) doses of test (200mg/week).

 

[simpllyhuge]

well any way im a few days into Aifm and i must say i need a few more days but i think its definatly increasing my libido.

macro, is it possible to keep off pretty much all bloat on high doses of test with any Aromatase inhibitor (AI) including aifm. i mean be on a gram and not bloated at all.

 

[macro]

yes