Infertility, is it a real concern?

DougoeFre5h said:
Has ANYONE you know/know of suffered lifetime infertility due to steroid use? Id like to hear any relavent info.
I was on gear for a good while and still got my wife pregnant :) I think I was on deca at the time. Well, at least I know my sperm works.
 
I've done a good bit of research on this, and it seems that Human Chorionic Gonadotropin (HCG) alone or combined with HMG will in fact increase sperm concentration as well as semenal volume after years of heavy Anabolic Androgenic Steroids (AAS) use. However, there are still those who may not respond as well to the treatment. It's a major concern of mine, too. These 3 studies may be of interest.


1)

Fertil Steril. 2004 Jan;81(1):226.

Successful treatment of anabolic steroid-induced azoospermia with human chorionic gonadotropin and human menopausal gonadotropin.

Menon DK.

Department of Obstetrics and Gynecology, University Malaya Medical Centre, Kuala Lumpur, Malaysia. drmenon2000@yahoo.co.uk

OBJECTIVE: To document for the first time the successful treatment using human chorionic gonadotropin (hCG) and human menopausal gonadotropins (hMG) of anabolic steroid-induced azoospermia that was persistent despite 1 year of cessation from steroid use. DESIGN: Clinical case report. SETTINGS: Tertiary referral center for infertility. PATIENT(S): A married couple with primary subfertility secondary to azoospermia and male hypogonadotropic hypogonadism. The husband was a bodybuilder who admitted to have used the anabolic steroids testosterone cypionate, methandrostenolone, oxandrolone, testosterone propionate, oxymetholone, nandrolone decanoate, and methenolone enanthate. INTERVENTION(S): Twice-weekly injections of 10,000 IU of hCG (Profasi; Serono) and daily injections of 75 IU of hMG (Humegon; Organon) for 3 months. MAIN OUTCOME MEASURE(S): Semen analyses, pregnancy. RESULT(S): Semen analyses returned to normal after 3 months of treatment. The couple conceived spontaneously 7 months later. CONCLUSION(S): Steroid-induced azoospermia that is persistent after cessation of steroid use can be treated successfully with hCG and hMG.

2)

J Clin Endocrinol Metab. 1985 Oct;61(4):746-52. Related Articles, Links


Male hypogonadotropic hypogonadism: factors influencing response to human chorionic gonadotropin and human menopausal gonadotropin, including prior exogenous androgens.

Ley SB, Leonard JM.

Although testosterone (T) therapy is sufficient for maturation and maintenance of secondary sex characteristics in hypogonadal men, gonadotropins are required for stimulation of spermatogenesis. Thirteen men with hypogonadotropic hypogonadism received treatment with hCG, followed in 12 by the addition of human menopausal gonadotropin (hMG). All initially had undetectable serum LH and FSH and low T levels and were azoospermic with small testes. During therapy, all achieved normal male levels of T. Twelve of 13 had marked and continuous increase in testicular volume. Three men had sperm in the ejaculate with hCG treatment alone. All but 1 patient developed sperm in their seminal fluid during combined hCG and hMG therapy. Two men achieved three pregnancies, and 2 more had semen that produced hamster oocyte penetration assays in the fertile range during the protocol period. Four of 5 who achieved sperm densities greater than 1 million/ml while receiving combined therapy maintained or increased sperm production while receiving continued hCG therapy after hMG was withdrawn. We examined the response to gonadotropin therapy of men who had received previous T therapy and those who had not. There were no differences in rapidity or degree of response, as assessed by rise in serum T, increase in testis volume, or maximal sperm density achieved. Multiple pituitary deficits and cryptorchidism were negative prognostic factors. In summary, the prognosis for successful stimulation of spermatogenesis in men with hypogonadotropic hypogonadism treated with hCG/hMG is good and not adversely affected by prior androgen treatment. Despite undetectable serum FSH levels, hCG treatment was sufficient to both initiate and maintain spermatogenesis in some patients.

3)

Urology. 2000 Oct 1;56(4):669. Related Articles, Links


Acquired hypogonadotropic hypogonadism presenting as decreased seminal volume.

Tash JA, McGovern JH, Schlegel PN.

James Buchanan Brady Urology Foundation, Department of Urology, The New York Presbyterian Hospital-Weill Medical College of Cornell University, New York, New York, USA.

A 32-year-old man with decreased ejaculatory volume was found to have acquired hypogonadotropic hypogonadism. Initial evaluation demonstrated castrate levels of testosterone with low serum follicle-stimulating hormone (FSH) and luteinizing hormone (LH) levels. Semen analysis revealed a volume of 0.35 cc and severe oligospermia. Administration of gonadotropin-releasing hormone (GnRH) did not effect an increase in LH or FSH, indicating a pituitary defect. Magnetic resonance imaging revealed a partially empty sella turcica. Treatment with human chorionic gonadotropin (hCG) alone resulted in normalization of testosterone levels, sperm concentration, and semen volume, as well as the successful conception and delivery of a healthy baby girl. The findings from this case demonstrate the importance of considering low serum testosterone levels in the evaluation of low semen volume, as well as the role of hCG alone as an infertility treatment for acquired hypogonadotropic hypogonadism.
 
In theory anyone forced into hrt would be infertile correct? We know this does happen to a fair number of guys.
 
Good clinical study that was presented there are many issues to review tha the study had as entry criteria. Having said that. I impresgneated my wife while on Deca, Test. My second child she was concieved while not taking anything. Now fast forward three years and I had a semen test and I am shooting blanks, having testinmg done. The Dr. had even told me and he is known as a very sound reproductive endo/urology. He claims out of all the gear Decca is the worst on the reproductive system, in many cases it either shuts you down compltly, or you will need Human Chorionic Gonadotropin (HCG), Clomid etc,, therapy for up to one year. Each body is different, and your PTH levels react different predicated on many outside factors. Get treatment from your Dr. and listen to what he says. My best friend just went through this, and now will go on Human Chorionic Gonadotropin (HCG) THerapy for a minimium of 6 months, if not then possible he will have HRT for the rest of his life. It is a role if the dice ! Good luck, we all have expierenced this to some point or another, and mainly if you are older !
 
LiftTillIDie said:
In theory anyone forced into hrt would be infertile correct?
Nope, especially when using hCG. And in the case when hCG doesn't work, add a little HMG. If that doesn't work, then I question if the person ever was fertile.
 
DougoeFre5h said:
Has ANYONE you know/know of suffered lifetime infertility due to steroid use? Id like to hear any relavent info.
Just get yourself fixed so you don't have to worry about it. :D

I'm not serious, since I've run into a guy that suffered severe problems because the procedure didn't go right. I can't remember what happened, but in some cases the semem leaks out or something and the body attacks itself.

I wonder if I wrote this down somewhere.
 
mranak said:
Just get yourself fixed so you don't have to worry about it. :D

I'm not serious, since I've run into a guy that suffered severe problems because the procedure didn't go right. I can't remember what happened, but in some cases the semem leaks out or something and the body attacks itself.

I wonder if I wrote this down somewhere.
haha, actually it the other way around. I worry often that I will have trouble having a child when I do get to that time, but I believe much of my fear is based on rumor/myth. Nice to see some studied done with actual Anabolic Androgenic Steroids (AAS) users. I gotta use pub-med more often.
 
DougoeFre5h said:
haha, actually it the other way around.
=O

DougoeFre5h said:
I worry often that I will have trouble having a child when I do get to that time, but I believe much of my fear is based on rumor/myth. Nice to see some studied done with actual Anabolic Androgenic Steroids (AAS) users. I gotta use pub-med more often.
Study data is certainly lacking for real and pure Anabolic Androgenic Steroids (AAS) users.
 
DoSedO said:
what exactly is HMG ??
50% LH (real LH, not hCG, although it reallty doesn't make a difference)
50% FSH

It is really only the FSH that we care about since HMG (expensive) is typically used in conjunction with hCG (inexpensive).

Seems like a typical dose of HMG is 75iu of LH and 75iu of FSH, but I may be mistaken on this specific.
 
DougoeFre5h said:
haha, actually it the other way around. I worry often that I will have trouble having a child when I do get to that time, but I believe much of my fear is based on rumor/myth. Nice to see some studied done with actual Anabolic Androgenic Steroids (AAS) users. I gotta use pub-med more often.

I'm the same way. It's good to know that I can still have kids even if i have to go on hrt.
 
a good friend of mine abused steroids for years from his early twenties...he recalls with fondness his 22 inch arms ....now into his thirties he regrets it as hes permanately infertile and desperately wants children......he was in the 2g a week club year round for a long time though....
 
rockape76 said:
a good friend of mine abused steroids for years from his early twenties...he recalls with fondness his 22 inch arms ....now into his thirties he regrets it as hes permanately infertile and desperately wants children......he was in the 2g a week club year round for a long time though....
Has he had bloodwork done? Has it tried hCG and then hCG+HMG?
 
I think with 99.9% of men, it would be just a matter of time on a recovery regimen to regain fertility. As with everything, recovery times would differ for different individuals. However, you won't find a lack of people who got a woman pregnant while on cycle.
 
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