Labs "?" & Speed of E2 fluctuations

[Rockymtn]

I was just wondering if anyone knows how fast our E2 levels can fluctuate?
Is this typically a slow moving number or can it change pretty rapidly?
For example... I have been toying with my AI dose (adex), & was wondering just how fast & how much my E2 numbers would fluctuate in a certain amount of time in response to my adex dose (don't want a crash!!).
Now I know everyone is different and that a lot of different elements play into this equation, but just looking for ballpark relativity of how fluid this "number" realy is.

I just had bloodwork done, & my E2 numbers came back good, 21.2 pg/ml. But as I start to blast here & there, how often do I check my E2? Or do most guys just get labs on a set schedule? (Probably the best way to go, but how often?)
Also please feel free to comment on other high / low results.
Thanks
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[Mprtz]

I don't really have an answer, so can only speculate:

Anastrozole has a half life of about 50 hours. E2 has a half life of 13 hours.
Let's say you double your Anastrozole dose. Peak (new) levels are probably reached in less than one day, judging from the half life.
E2 half life is even shorter. I reason that establishing new E2 levels on a change in AI dose should happen "within a few days" - wouldn't want to get any more specific that that.

A lot will depend on the timing. Lots of guys on TRT dose Anastrozole twice weekly, which is actually a little long between doses for the stated half-life.

 

[daleb]

1) make sure its the right e2 lab, u want the sensitive estradiol test that uses lc/ms
2) make slow changes and stick to them for 4-6 weeks - retest.