t3 or t4 affecting shbg???

[simpllyhuge]

does any one know to what degree 100mcg of t4 would affect ones free test levels.?

 

[simpllyhuge]

would it increase shbg alot, i heard it might?

 

[DocJ]

You're on HGH too correct? That could cause a T4 deficiency d/t HGH increasing the conversion of T4 to T3.

 

[DocJ]

would it increase shbg alot, i heard it might?

Found these.....
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J Androl. 1988 May-Jun;9(3):215-9
Serum levels of total testosterone and sex hormone binding globulin in hypothyroid patients and normal subjects treated with incremental doses of L-T4 or L-T3.Cavaliere H, Abelin N, Medeiros-Neto G.
Department of Medicine, Hospital das Clinicas, Univ. Sao Paulo Medical School, Brazil.

Plasma testosterone (T) and sex hormone binding globulin (SHBG) were assayed in normal controls (N = 9) and hypothyroid patients (N = 17) receiving increasing doses of L-T4 (0.2 mg, 0.4 mg for 30 days), followed first by 30 days without medication and then by 30 days each of 0.05 mg L-T3 and 0.2 mg L-T3. Normal male controls showed a significant increase in plasma T only at high doses of either L-T4 (0.4 mg) or L-T3 (0.2 mg). A small but significant increase in plasma T levels was observed in normal female subjects at 0.4 mg of T4. In both men and women, plasma SHBG increased in a dose-dependent manner with L-T4 or L-T3 and correlated positively and significantly with serum thyroid hormone levels. Hypothyroid male subjects had significantly lower levels of plasma T (mean +/- SD) of 279 +/- 131 ng/dl as compared with normal males (431 +/- 118 ng/dl), which reached the normal range only at a relatively high dose of either L-T4 (0.4 mg) or L-T3 (0.2 mg). No significant changes in plasma T were seen in the hypothyroid female group. Basal plasma SHBG levels were significantly lower in both hypothyroid men and women and increased towards normal levels during L-T4 and L-T3 therapy, although the response to thyroid hormones was significantly lower than that of normal controls. These results indicate that thyroid hormone therapy increases plasma SHBG levels in both normal and hypothyroid patients and that this increase precedes the expected elevation of plasma T in males.

PMID: 3403362 [PubMed - indexed for MEDLINE

Eur J Endocrinol. 1995 May;132(5):594-8
Opposite effects of thyroid hormones on binding proteins for steroid hormones (sex hormone-binding globulin and corticosteroid-binding globulin) in humans.Dumoulin SC, Perret BP, Bennet AP, Caron PJ.
Department of Endocrinology, CHU Rangueil, Toulouse, France.

Sex hormone-binding globulin (SHBG) and corticosteroid-binding globulin (CBG) levels were evaluated in euthyroid (N = 111), hyper- (N = 58) and hypothyroid (N = 38) men, in pre- and postmenopausal women (study 1) and in hyper- (N = 24) and hypothyroid (N = 15) patients before and after treatment with carbimazole or levothyroxine therapy (study 2). The SHBG levels are increased in hyper- and decreased in hypothyroid patients, whereas CBG levels are increased in hypo- and decreased in hyperthyroid patients. The SHBG levels are higher in women than in men with similar thyroid status. Plasma SHBG levels are correlated positively whereas CBG levels are correlated negatively with free thyroid hormone concentrations in men as well as women. In hypothyroid patients, SHBG concentrations increased (p < 0.01) and CBG concentrations decreased (p < 0.01) during levothyroxine treatment. In hyperthyroid patients, SHBG concentrations decreased (p < 0.01) and CBG concentrations increased (p < 0.01) during antithyroid treatment. The SHBG and CBG concentrations in treated hypo- and hyperthyroid patients were not significantly different from those of euthyroid controls. Our data indicate that SHBG and CBG levels depend on thyroid status. Corticosteroid-binding globulin is an index of thyroid hormone action at the liver level whose changes are opposite to those of SHBG in hyper- and hypothyroidism.

PMID: 7749500 [PubMed - indexed for MEDLINE]

J Clin Endocrinol Metab. 1988 Apr;66(4):740-6
Sex hormone-binding globulin in the diagnosis of peripheral tissue resistance to thyroid hormone: the value of changes after short term triiodothyronine administration.Sarne DH, Refetoff S, Rosenfield RL, Farriaux JP.
Department of Medicine, University of Chicago, Illinois 60637.

Thyroid hormone is one of several factors that modulate the level of sex hormone-binding globulin (SHBG) in serum. SHBG levels are usually elevated in thyrotoxicosis and have been reported to be normal in a few patients with generalized resistance to thyroid hormone (GRTH). This study was designed to determine whether basal serum SHBG levels or the SHBG response to short term T3 administration could be used as an index of thyroid hormone action and thus serve as a test for the evaluation of patients suspected of having peripheral tissue resistance to thyroid hormone. Serum SHBG, total T4, free T4 index (FT4I), total T3, and TSH levels were measured in 21 normal subjects, 28 hypothyroid patients, 20 thyrotoxic patients, and 10 patients with GRTH. Excluding patients with GRTH, serum basal SHBG values were correlated with FT4I values (r = 0.66; P less than 0.0001). Mean SHBG levels in the patients with GRTH [37.6 +/- 16.2 (+/- SD) nmol/L] were not significantly different from those in the normal subjects (35.1 +/- 19.3 nmol/L) or hypothyroid patients (26.3 +/- 17.1 nmol/L), but were significantly lower than those in the thyrotoxic group (64.7 +/- 19.2 nmol/L; P less than 0.001). All 10 patients with GRTH had basal SHBG values in the normal range, but 7 of 20 (35%) thyrotoxic patients also had normal basal SHBG values. T3 was given orally for three sequential 3-day periods at doses of 50, 100, and 200 micrograms daily to 7 normal subjects, 11 hypothyroid and 3 thyrotoxic patients, and all 10 patients with GRTH. The serum SHBG concentration was measured on the last day at each dosage level. During T3 administration, SHBG levels increased in all individuals with normal tissue responsiveness. The increase above the basal value (delta SHBG) at each T3 dose was similar in normal, hypothyroid, and thyrotoxic individuals (non-resistant subjects). After administration of 50 micrograms T3 daily, the mean delta SHBG level was decreased [-2.9 +/- 5.3 (+/- SD) nmol/L] in the resistant patients and increased (4.0 +/- 4.9 nmol/L; P less than 0.005) in the nonresistant subjects. After administration of 100 micrograms T3 daily, the mean delta SHBG was -4.5 +/- 6.8 nmol/L in the resistant patients and 8.6 +/- 5.1 nmol/L (P less than 0.0001) in the nonresistant subjects. Serum SHBG decreased by more than 2 nmol/L in 6 of 10 (60%) resistant patients, but in no nonresistant subject.(ABSTRACT TRUNCATED AT 400 WORDS)

PMID: 3346353 [PubMed - indexed for MEDLINE]

 

[simpllyhuge]

sorry i read them but im still confused. I think what i got from the articles is that only in huge dossages.? im only taking 100mcg t4

 

[DocJ]

Let's concentrate on the first study as the other two are worded f'd-up and the last one's truncated which I didn't notice when I posted (sorry). Bottom line is, yes, it's definately possible.

 

[simpllyhuge]

ok what about if when its time to come off the t4 i keep running the gh while my thyroid recovers? or will this not work.

and in your personal guess u think 100mcg of t4 is affecting my shbg that much.

 

[DocJ]

ok what about if when its time to come off the t4 i keep running the gh while my thyroid recovers? or will this not work.

and in your personal guess u think 100mcg of t4 is affecting my shbg that much.

I'm not sure what you're asking in the first sentence...plenty of people run HGH for months and months without any thyroid meds and are fine.


Probably not that much since you're on HGH.

 

[simpllyhuge]

ok sorry let me explain it better. RIght now im on t4 100mcg a day and gh. I thought the idea behind taking the t4 is to replace the amount that gh might supress somewhat. Can i run the gh longer than the t4 purposly in an attempt to allow my thyroid to start pumping out natural t4 again while still be on gh which i hope well keep me from putting on fat while my thyroid is recovering.

 

[DocJ]

Ahh, I get it, yes that should work.

 

[simpllyhuge]

thanks

 

[cooldude_1981]

it might check my bloodwork i just posted it on the top