The mystery of anadrol

[JuiceAuthority]

Please tell me your kidding me right? You are trying to teach me about the difference between a SERM and AI? hahahahahaha

your studies are kinda worthless, you do realise that nolva acts completely different in different tissues right?

Intitially, Nolva down regulates the PGR, then after like 2 weeks it will reverse. just read what RJ posted and it will answer your questions

If you had half a clue what I posted supported your previous post where you stated it up-regulates the ER. I was simply pointing out that Nolva up-regulates both the ER and the PR.

We have drugs we can use to control estro levels (AIs) but why the fuck would I take a SERM with a progestin if it is clinically proven upregulate the PR??? There are no drugs that prevent progesterone from binding to the PR. Do you get that???

 

[THE-DET-OAK]

if you had half a clue what i posted supported your previous post where you stated it up-regulates the er. I was simply pointing out that nolva up-regulates both the er and the pr.

we have drugs we can use to control estro levels (ais) but why the fuck would i take a serm with a progestin if it is clinically proven upregulate the pr??? there are no drugs that prevent progesterone from binding to the pr. Do you get that???

anadrol is not a fucking progestin!!!!!!!!!!!!!!!

 

[THE-DET-OAK]

even if it was, which its not, it would be out of your system WAAAAAAAYY before the PGr was upr-regulated!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! know who your talking to before you open your mouth son!!!!

 

[ECKSRATED]

We need to get James Carville into this debate!!!

 

[JuiceAuthority]

anadrol is not a fucking progestin!!!!!!!!!!!!!!!

No shit. If you have even a modicum of reading comprehension ability you would have noticed that I'm running Sustanon (sust), Deca (a progestin) and Drol.

 

[THE-DET-OAK]

listen the debate is about what will help drol gyno, if i got off track my bad, I only responded in regards to drol gyno.

 

[JuiceAuthority]

even if it was, which its not, it would be out of your system WAAAAAAAYY before the PGr was upr-regulated!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!! know who your talking to before you open your mouth son!!!!

Seriously, all you're doing is adding clutter and nonsense to an otherwise decent discussion.

 

[JuiceAuthority]

listen the debate is about what will help drol gyno, if i got off track my bad, I only responded in regards to drol gyno.

The topic of the thread was drol but the purpose of the thread was to better understand why adding drol to Sustanon (sust) and Deca is causing me gyno symptoms when I'm running aroma for estro control and caber to reduce prolactin levels from Deca.

 

[THE-DET-OAK]

what are you talking about? your OP says you havent even started it yet

 

[THE-DET-OAK]

I just went back through the thread, you dont say shit about what else your running, the whole thread is set up for drol gyno and thats it, your the one fucking this up.

 

[cashout]

I wasn't comparing it to test. If you want a better comparator use var, which is much more anabolic than drol.

Anadrol 50:
Androgenic: Anabolic Ratio: 45:320

Anavar:
Anabolic/Androgenic Ratio (Range): 322-630:24

Also, drol is not a DHT steroid. It is derived from DHT but it is not in the that drug class. And it also not a progestin or a compound with progestenic activity, so the estrogenic side effects still remain unknown.

I'd like to see the study or any info that supports the direct binding activity to ER. That would help explain things since everything I've read indicates different.

I simply refuted what you wrote. It is not a weak anabolic. Compare it to whatever you want. The ratios you quoted are actually for methyl test, if you want to split hairs.

DHT reduced = DHT derivative and yes, it is a derivation of DHT - that is exactly what I wrote. Again, if you want to split hairs.

I never stated that it had any progestional activity, in fact I stated the opposite - it has been shown to have no progestional activity. Don't know how you read that in what I wrote.

PubMed has 2 studies that I found with one 2 second query. Try it.

 

[RA64]

I just went back through the thread, you dont say shit about what else your running, the whole thread is set up for drol gyno and thats it, your the one fucking this up.

Thanks Oak, I thought I was the only one didn't see where he said what he was running.

 

[RA64]

I was comparing drol to other 17aas. It no more anabolic than Winstrol (winny) and less androgenic. Anavar (var) is much more anabolic than drol and less androgenic as well.

Ok now that statement is total bullshit.

I have ran Anadrol-50 back in the 90's and also Anavar (var) and Winstrol (winny), and it kicks both of those compounds ass.

 

[JuiceAuthority]

I just went back through the thread, you dont say shit about what else your running, the whole thread is set up for drol gyno and thats it, your the one fucking this up.

Did you? Go read post #6. The parts in bolds below will make for easier reading comprehension.

I care. I have some prescription drol that I was planning on running for the next 2.5 weeks and already I'm noticing symptoms (it's only been 2 days). It's a low dose of drol too (50mgs/ed).

Let's say for argument's sake it is progestogenic even though that fact has never been established. Dopamine agonists are absolutely USELESS to prevent progesterone related gyno. All they do is reduce prolactin levels, which certainly aren't elevated from 2 days of drol. They don't prevent progesterone from binding to the PR.

I've been running pharma grade caber and aroma since I'm cycling test and deca so it's certainly not the prolactin. btw, nothing prevents progesterone from binding to the PR except the absorption pill. Winstrol (winny) and B6 are said to provide "some" blockage but who knows? All I know is I've been taking B6, caber, and aroma and haven't noticed any gyno symptoms UNTIL I started the drol.

 

[JuiceAuthority]

Ok now that statement is total bullshit.

I have ran Anadrol-50 back in the 90's and also Anavar (var) and Winstrol (winny), and it kicks both of those compounds ass.

Totally agree. So much for the "stated" anabolic/androgenic ratios. It really doesn't mean shit, but then again, someone else went there first. That said the gains made on Winstrol (winny) and Anavar (var) are better from the standpoint that you look better and you're far less bloated.

 

[JuiceAuthority]

I simply refuted what you wrote. It is not a weak anabolic. Compare it to whatever you want. The ratios you quoted are actually for methyl test, if you want to split hairs.

DHT reduced = DHT derivative and yes, it is a derivation of DHT - that is exactly what I wrote. Again, if you want to split hairs.

I never stated that it had any progestional activity, in fact I stated the opposite - it has been shown to have no progestional activity. Don't know how you read that in what I wrote.

PubMed has 2 studies that I found with one 2 second query. Try it.

If you want to further "split hairs" EVERY form of AAS is "derived" from Testosterone. I stand corrected in saying drol is a "weak" anabolic based on the "ratios", and of course depending of the "comparator" (I used var) but it is very interesting, ratios asides, that drol has such pronounced androgenic sides, no?

This was what I disagreed with relative to my cycle (Sust, Deca and more recently, drol):

The best line of defense for Anadrol-induced gyno would be Nolva.

Now if I was running Sustanon (sust) and drol perhaps Nolva would be a viable option but not with a progestin, imo.

That said Aroma is far superior to Nolva for estro control AND estrogen related gyno. It deactivates the aromatase enzyme, reduces circulating estrogen in the body and reverses the early stages gyno before it hardens. Why take Nolva instead of Aroma? Nolva prevents estrogen from binding to the ER. It sucks as an anti-e.

 

[burlyman]

Originally Posted by JuiceAuthority
I was comparing drol to other 17aas. It no more anabolic than Winstrol (winny) and less androgenic. Anavar (var) is much more anabolic than drol and less androgenic as well.

RA64:
Ok now that statement is total bullshit.

I have ran Anadrol-50 back in the 90's and also Anavar (var) and Winstrol (winny), and it kicks both of those compounds ass.

Totally agree. So much for the "stated" anabolic/androgenic ratios. It really doesn't mean shit, but then again, someone else went there first. That said the gains made on Winstrol (winny) and Anavar (var) are better from the standpoint that you look better and you're far less bloated.

Wow, this is all over the place. You disagree with yourself and agree with RA, while then still disagreeing with yourself and RA on the same subject.

 

[glubgawd]

I can't believe this thread is still going......it's getting painful.....

 

[RJ]

I firmly believe this asshat is here to do nothing but ruffle feathers as that is all he has done in the past week. He is contradicting himself left and right, which only further proves that point.

And I'll paste it here as you didn't even read the thread about it. You just spit out some parroted bullshit like every other know it all on this board. They are two different tissues, thus the up and down regulation of the PgR.

In some tissues, such as the endometrium (uterus), upregulation of the progesterone receptor would be expected, as the endometrium is very sensitive to estrogen. This is where i believe there is confusion.

In other tissues, such as the breast, Tamoxifen is an antagonist (blocks the ER). The progesterone receptor is synthesized in response to estrogen. So when the ER is blocked (in breast tissue), the progesterone receptor will also down regulate. This is what happens in cancer patients and we're no different.

Now please stop with this nonsense. You sound like an idiot.

Hey DET - do you know what SERM even stands for?

 

[DADAWG]

my 2 cents worth

drol is just like other compounds that we dont understand its been around forever and has been known to cause gyno issues even though it shouldnt be that bad scientifically .it also adds a LOT of mass / very anabolic even though on paper some say it shouldnt be.

just because we cant prove why something works or causes a side effect does NOT mean it doesnt mean it isnt true.there is to much real world experience out there not to know that drol is a anabolic monster and that drol can cause progesterone / prolactin issues either directly or indirectly.


proviron is the same way , on paper its NOT a anti estrogen or at the most it is a very weak one but real world experience that i have seen shows much less bloat on cycles when run with proviron.


use your own REAL world experience and the experience of trusted vets and mods.